Intact HCG, free HCG β subunit and HCG β core fragment: Longitudinal patterns in urine during early pregnancy

Human Reproduction

Volumn 20, Issue 4, 2005, Pages 928-935

  McChesney, Ruth ^a   Wilcox, Allen J ^b   O'Connor, John F ^c   Weinberg, Clarice R ^b   Baird, Donna D ^b   Schlatterer, John P ^c   McConnaughey, D Robert ^d   Birken, Steven ^c   Canfield, Robert E ^c  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c Columbia University ^*  (United States)

^d WESTAT   (United States)

Author keywords

HCG; Longitudinal patterns; Pregnancy; Urine

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT;

ADULT; ARTICLE; CALCULATION; CHILDBIRTH; CLINICAL TRIAL; CONCEPTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; HORMONE DETERMINATION; HORMONE URINE LEVEL; HUMAN; MEASUREMENT; MONITORING; PREGNANCY TEST; RELIABILITY; URINALYSIS;

EID: 18744377740     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deh702     Document Type: Article

References (40)

1. Armstrong EG, Ehrlich PH, Birken S, Schlatterer JP, Siris E, Hembree WC and Canfield RE (1984) Use of a highly sensitive and specific immunoradiometric assay for detection of human chorionic gonadotropin in urine of normal, nonpregnant, and pregnant individuals. J Clin Endocrinol Metab 59,867-874.
2. Baird DD, Weinberg CR, Wilcox AJ, McConnaughey DR and Musey PI (1991) Using the ratio of urinary oestrogen and progesterone metabolites to estimate day of ovulation. Stat Med 10,255-266.
3. Baird DD, McConnaughey DR, Weinberg CR, Musey PI, Collins DC, Kesner JS, Knecht EA and Wilcox AJ (1995) Application of a method for estimating day of ovulation using urinary estrogen and progesterone metabolites. Epidemiology 6,547-550.
4. Batzer FR, Schlaff S, Goldfarb AF and Corson SL (1981) Serial β-subunit human chorionic, gonadotropin doubling time as a prognosticator of pregnancy outcome in an infertile population. Fertil Steril 35,307-312.
5. Bernstein L, Pike ML, Lobo RA, Depue RT, Ross RK and Henderson BE (1989) Cigarette smoking in pregnancy results in marked decrease in maternal hCG and oestradiol levels. Br J Obstet Gynaecol 96,92-96.
6. Birken S, Armstrong EG, Kolks MAG, Cole LA, Agosto GM, Krichevsky A, Vaitukaitis JL and Canfield RE (1988) Structure of the human chorionic gonadotropin β-subunit fragment from pregnancy urine. Endocrinology 123,572-583.
7. Birken S, Chen Y, Gawinowicz MA, Agosto GM, Canfield RE and Hartree AS (1993) Structure and significance of human luteinizing hormone-β core fragment purified from human pituitary extracts. Endocrinology 133,985-989.
8. Birken S, Yershova O, Myers RV, Bernard MP and Moyle W (2003) Analysis of human choriogonadotropin core 2 o-glycan isoforms. Mol Cell Endocrinol 204,21-30.
9. Blithe DL, Akar AH, Wehmann RE and Nisula BC (1988) Purification of β-core fragment from pregnancy urine and demonstration that its carbohydrate moieties differ from those of native human chorionic gonadotropin-β. Endocrinology 122,173-180.
10. Bremme K, Lagerstrom M, Andersson O, Johansson S and Eneroth P (1990) Influences of maternal smoking and fetal sex on maternal serum oestriol, prolactin, hCG, and hPL levels. Arch Gynecol Obstet 247,95-103.
11. Butler SA, Khanlian SS and Cole LA (2001) Detection of early pregnancy forms of human chorionic gonadotropin by home pregnancy test devices. Clin Chem 47,2131-2136.
12. Canfield RE, O'Connor JF, Birken S, Krichevsky A and Wilcox AJ (1987) Development of an assay for a biomarker of pregnancy and early fetal loss. Environ Health Perspect 74,57-66.
13. Chard T (1992) Pregnancy tests: a review. Hum Reprod 7,701-719.
14. Cole LA, Seifer DB, Kardana A and Braunstein GD (1993) Selecting human chorionic gonadotropin immunoassays: consideration of cross-reacting molecules in first-trimester pregnancy and urine. Am J Obstet Gynecol 163,1580-1586.
15. de Medeiros SF, Amato F, Matthews CD and Norman RJ (1992) Urinary concentrations of beta core fragment of hCG throughout pregnancy. Obstet Gynecol 80,223-230.
16. Diaz-Cueto L, Mendez JP, Barrios-de-Tomasi J, Lee J-Y, Wide L, Veldhuis JD and Ulloa-Aguirre A (1994) Amplitude regulation of episodic release, in vitro biological to immunological ratio, and median charge of human chorionic gonadotropin in pregnancy. J Clin Endocrinol Metab 87, 890-897.
17. Dunson DB, Weinberg CR, Baird DD, Kesner JS and Wilcox AJ (2001) Assessing fertility using several markers of ovulation. Stat Med 20, 965-978.
18. Echochard R, Boehringer H, Rabilloud M and Marret H (2001) Chronological aspects of ultrasonic, hormonal, and other indirect indices of ovulation. Br J Obstet Gynaecol 108,822-829.
19. Elliott MM, Kardana A, Lustbader JW and Cole LA (1997) Carbohydrate and peptide structure of the alpha and beta subunits of chorionic gonadotropin (hCG): characteristics and variants in 32 subunit preparations from normal and aberrant pregnancy and choriocarcinoma. Endocrine 7,15-32.
20. Fritz MA and Guo S (1987) Doubling time of human chorionic gonadotropin (hCG) in early normal pregnancy: relationship to hCG concentration and gestational age. Fertil Steril 47,584-589.
21. Kato Y and Braunstein GD (1988) β-Core fragment is a major form of immunoreactive urinary chorionic gonadotropin in human pregnancy. J Clin Endocrinol Metab 66,1197-1201.
22. Kovalevskaya G, Birken S, Kakuma T, Schlatterer J and O'Connor JF (1999) Evaluation of nicked human chorionic gonadotropin content in clinical specimens by a specific immunometric assay. Clin Chem 45, 68-77.
23. Kovalevskaya G, Birken S, Kakuma T, Ozaki N, Sauer M, Lindheim S, Cohen M, Kelly A, Schlatterer J and O'Connor JF (2002) Differential expression of human chorionic gonadotropin (hCG) glycosylation isoforms in failing and continuing pregnancies: preliminary characterization of the hyperglycosylated hCG epitope. J Endocrinol 172,497-506.
24. Krichevsky A, Birken S, O'Connor J, Bikel K, Schlatterer J, Chen Y, Agosto G and Canfield R (1991) Development and characterization of a new, highly specific antibody to the human chorionic gonadotropin β-subunit. Endocrinology 128,1255-1264.
25. Lenton EA, Neal LM and Sulaiman R (1982) Plasma concentrations of human chorionic gonadotropin from the time of implantation until the second week of pregnancy. Fertil Steril 37,773-778.
26. Lopata A, Martin M, Oliva K and Johnston I (1982) Embryonic development and blastocyst implantation following in vitro fertilization and embryo transfer. Fertil Steril 38,682-687.
27. Mishalani SH, Seliktar J and Braunstein GD (1994) Four rapid serum-urine combination assays of choriogonadotropin (hCG) compared and assessed for their utility in quantitative determinations of hCG. Clin Chem 40, 1944-1949.
28. Mishell DR, Nakamura RM, Barberia JM and Thorneycroft IH (1974) Initial detection of human chorionic gonadotropin in serum in normal human gestation. Am J Obstet Gynecol 118,990-991.
29. Mock P, Kovalevskaya G, O'Connor JF and Campana A (2000) Choriocarcinoma-like human chorionic gonadotrophin (HCG) and HCG bioactivity during the first trimester of pregnancy. Hum Reprod 15,2209-2214.
30. Norman RJ, Menabawey M, Lowings C, Buck RH and Chard T (1987) Relationship between blood and urine concentrations of intact human chorionic gonadotropin and its free subunits in early pregnancy. Obstet Gynecol 69,590-593.
31. O'Connor JF, Schlatterer JP, Birken S, Krichevsky A, Armstrong EG, McMahon D and Canfield RE (1988) Development of highly sensitive immunoassays to measure human chorionic gonadotropin, its β-subunit, and β-core fragment in the urine: application to malignancies. Cancer Res 48,1361-1366.
32. O'Connor JF, Birken S, Lustbader JW, Krichevsky A, Chen Y and Canfield RE (1994) Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements. Endocr Rev 15,650-683.
33. O'Connor JF, Ellish N, Kakuma T, Schlatterer J and Kovalevskaya G (1998) Differential urinary gonadotrophin profiles in early pregnancy and early pregnancy loss. Prenat Diagn 18,1232-1240.
34. Olsen TG, Hubert PR and Nycum LR (2001) Falsely elevated human chorionic gonadotropin leading to unnecessary therapy. Obstet Gynecol 98, 843-845.
35. Pittaway DE, Reish RL and Wentz AC (1985) Doubling times of human chorionic gonadotropin increase in early viable intrauterine pregnancies. Am J Obstet Gynecol 152,299-302.
36. Wehmann RE and Nisula BC (1981) Metabolic and renal clearance rates of purified human chorionic gonadotropin. J Clin Invest 68,184-194.
37. Weinans MJ, Butler SA, Mantingh A and Cole LA (2000) Urinary hyperglycosylated hCG in first trimester screening for chromosomal abnormalities. Prenat Diagn 20,976-978.
38. Wilcox AJ, Weinberg CR, Wehmann RE, Armstrong EG, Canfield RE and Nisula BC (1985) Measuring early pregnancy loss: laboratory and field methods. Fertil Steril 44,366-374.
39. Wilcox AJ, Weinberg CR, O'Connor JF, Baird DD, Schlatterer JP, Canfield RE, Armstrong EG and Nisula BC (1988) Incidence of early loss of pregnancy. N Engl J Med 319,189-194.
40. Wilcox AJ, Baird DD and Weinberg CR (1999) Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 340,1796-1799.