Degradation of a lyophilized formulation of BMS-204352: Identification of degradants and role of elastomeric closures

Pharmaceutical Development and Technology

Volumn 10, Issue 2, 2005, Pages 227-232

  Nassar, Munir N ^a   Nesarikar, Vishwas V ^a   Lozano, Ruben ^a   Huang, Yande ^a   Palaniswamy, Venkatapuram ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Desfluorohydoxy analog; Elastomeric closures; Formaldehyde; Formaldehyde adduct; Hydroxymethyl degradant

Indexed keywords

3 (5 CHLORO 2 METHOXYPHENYL) 3 FLUORO 2,3 DIHYDRO 6 TRIFLUOROMETHYL 1H INDOL 2 ONE; BMS 188929; BMS 215842; ELASTOMER; FORMALDEHYDE; HYDROXYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; DRUG DEGRADATION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG STABILITY; FREEZE DRYING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; ELASTOMERS; EXCIPIENTS; FREEZE DRYING; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY;

EID: 18744377490     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-200054429     Document Type: Article

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