Toxoplasma gondii Antigens GRA1 (p24) and SAG1 (p30): A comparison of their stimulatory influence on T-cell activation and cytokine expression in in vitro cultures

Pathobiology

Volumn 72, Issue 3, 2005, Pages 160-164

  Kato, M ^b   Claveria, F G ^a   Maki, Y ^c   Tanaka, T ^d   Suzuki, N ^e   Nagasawa, H ^e  

^a DE LA SALLE UNIVERSITY   (Philippines)

^b Dept of Diagnostics and Biotech

^c Sigma Genosys Japan Co   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

^e OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

Author keywords

GRA 1; SAG 1; T cell activation; Toxoplasma gondii

Indexed keywords

ANTIGEN P24; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 12; PROTEIN P30; RECOMBINANT ANTIGEN; RECOMBINANT ANTIGEN P 24; RECOMBINANT PROTEIN P 30; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBODY DETECTION; ANTIBODY TITER; ANTIGENICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE ACTIVATION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CELLS, CULTURED; FEMALE; GENE EXPRESSION; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; PROTOZOAN PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TOXOPLASMA;

TOXOPLASMA GONDII;

EID: 18744377482     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000084120     Document Type: Article

References (33)

1. Remington JS, Desmonst G: Toxoplasmosis; in Remington JS, Klein (eds): Infectious Diseases of the Fetus and Newborn Infant: Philadelphia, Saunders, 1983, pp 143-161.
2. Hunter CA, Remington JS: Immunopathogenesis of toxoplasmic encephalitis. J Infect Dis 1994;170:1057-1067.
3. Maki Y, Seng S, Kato M, Hoshi Y, Igarashi I, Nagasawa H, Toyoda Y, Suzuki N: Sequence analysis of three antigens (P30, P23 and P22) of virulent and avirulent strains of Toxoplasma gondii. J Protozool Res 1996;6:83-93.
4. Mineo JR, Kasper JK: Attachment of Toxoplasma gondii to host cells involves major surface protein, SAG-1 (P30). Exp Parasitol 1994;79:11-20.
5. Cesbron-Delauw MF, Guy B, Torpier G, Pierce RJ, Lenzen G, Kasper LH: Identification of stage-specific sporozoite antigens of Toxoplasma gondii. Infect Immunol 1989;57:668-672.
6. Kato M, Maki Y, Inoue N, Omata Y, Claveria FG, Igarashi I, Saito A, Suzuki N: Toxoplasma lysate antigen (TLA-144)-Ig8 antigenic component: Studies on binding and induction of cytotoxic cell activity in mouse spleen cell. J Protozool Res 1994;4:149-157.
7. Miyahara K, Matsumoto T, Tose S, Sakurai H, Igarashi I, Saito A, Hirose T, Suzuki N: Characteristic of cytotoxic cells induced by Toxoplasma lysate antigen (TLA) in mouse spleen. J Vet Med Sci 1992;54:87-93.
8. Bourguin I, Moser M, Buzoni-Gatel D, Tielemans F, Bout D, Urbain J, Leo O: Murine dendritic cells pulsed in vitro with Toxoplasma gondii antigens induce protective immunity in vivo. Infect Immun 1998;66:4867-4874.
9. Seng S, Makala LHC, Maki Y, Choi Y, Yokoyama M, Suzuki N, Toyoda Y, Nagasawa H: Unresponsiveness to surface antigen 1 modifies cytokine profile in acute Toxoplasma gondii infection. Pathobiology 2002;70:237-246.
10. Khan IA, Ely KH, Kasper LH: A purified parasite antigen (p30) mediates CD8+ T cell immunity against fatal Toxoplasma gondii infection in mice. J Immunol 1991;147:3501-3506.
11. Khan IA, Smith KA, Kasper LH: Induction of antigen-specific parasiticidial cytotoxic T cell splenocytes by a major membrane protein p30 of Toxoplasma gondii. J Immunol 1988;141:3600-3605.
12. Khan IA, Eckel M, Pfeffer ER, Kasper LH: Production of interferonγ by cultured human lymphocytes stimulated with a purified membrane protein (p30) of Toxoplasma gondii. J Infect Dis 1988;157:979-984.
13. Khan IA, Ely KH, Kasper LH: Antigen specific CD8+ T cell clone protects against acute Toxoplasma infection in mice. J Immunol 1994;152:1856-1860.
14. Khan IA, Matsuura T, Kasper LH: Interleukin-12 enhances murine survival against acute toxoplasmosis. Infect Immun 1994;62:1639-1645.
15. Parker SJ, Roberts CW, Alexander J: CD8+ T cells are the major lymphocyte subpopulation involved in the protective immune response to Toxoplasma gondii in mice. Clin Exp Immunol 1991;84:2310-2316.
16. Cesbron-Delauw MF, Lecordier R, Mercier C: Role of secretory dense granule organelles in the pathogenesis of toxoplasmosis. Curr Top Microbiol Immunol 1996;219:59-64.
17. Fischer HG, Stachelhaus S, Sahm M: GRA7, an excretory 29 kDa Toxoplasma gondii dense granule antigen released by infected host cells. Mol Biochem Parasitol 1998;91:251-262.
18. Cesbron GY, Charif H, Lepage P, Darcy F, Lecocq JP, Capron A: Molecular characterization of a 23-kilodalton major surface antigen secreted by Toxoplasma gondii. Proc Natl Acad Sci USA 1989;86:7537-7541.
19. Duquesne VC, Auriault H, Gras-Masse C: Identification of T cell epitopes within a 23 kDa antigen (p24) of Toxoplasma gondii. Clin Exp Immunol 1991;84:527-534.
20. Supply P, Sutton P, Coughlan SN: Immunogenicity of recombinant BCG producing the GRA1 antigen from Toxoplasma gondii. Vaccine 1999;17:705-714.
21. Valkoun A: Continual cultivation of Toxoplasma gondii on HeLa cells. Folia Parasitol (Praha) 1983;30:289-294.
22. Nagasawa H, Igarashi I, Matsumoto Y, Sakurai H, Marbella C, Suzuki N: Mouse spleen cell-derived Toxoplasma growth inhibitory factor: Its separation from macrophage migration inhibitory factor. Immunobiology 1980;157:307-319.
23. Saito A, Sakurai H, Terada S, Igarashi I, Suzuki N, Osaki H, Kudo H, Sakata Y, Okamoto K, Yoshida H: Inhibitory effect of Toxoplasma lysate antigen on the multiplication of transplanted tumour in mice. Zbl Bakt Hyg 1989; 271:114-126.
24. Bradford MM: A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976;72:248-254.
25. Crouch SPM, Kozlowski R, Slater KJ: The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. J Immunol Methods 1993;160,81-83.
26. Troutt AB, Kelso A: Enumeration of lymphokine mRNA containing cells in vivo in a murine graft-versus-host reaction using PCR. Proc Natl Acad Sci USA 1992;89:5276-5280.
27. Heufler C, Koch F, Stanzl U, Topar G, Wysocka M, Trinchieri G, Enk A, Steinman RM, Romani N, Shuler G: Interleukin 12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-γ production by T helper 1 cells. Eur J Immunol 1996;26:659-668.
28. Neyer LE, Grunig G, Fort M, Remington JS, Rennick D, Hunter CA: Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii. Infect Immun 1997;65:1675-1682.
29. Fiorentino DF, Bond M, Mosmann TR: Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989;170:2081-2095.
30. Manetti R, Parronchi P, Giuduzu MG, Piccinni MP, Magi E, Trinchieri G, Romagnani S: Natural killer cell stimulatory factor (interleukin 12 [IL12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993;177:1199-1204.
31. Gerondakis S, Grumont R, Rourke I, Grossmann M: The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation. Curr Opin Immunol 1998;10:353-359.
32. May MJ, Ghosh S: Signal transduction through NF-κB. Immunol Today 1998;19:80-88.
33. Vercammen M, Scorza T, Huygen K: DNA vaccination with genes encoding Toxoplasma gondii antigens, GRA1, GRA7 and ROP2 induce partially protective immunity against lethal challenge in mice. Infect Immun 2000;68:38-45.