Chronic nicotine treatment changes the axonal distribution of 68 kDa neurofilaments in the rat ventral tegmental area

European Journal of Neuroscience

Volumn 16, Issue 5, 2002, Pages 877-882

  Sbarbati, Andrea ^a   Bunnemann, Bernd ^b   Cristofori, Patrizia ^b   Terron, Andrea ^b   Chiamulera, Christian ^b   Merigo, Flavia ^a   Benati, Donatella ^a   Bernardi, Paolo ^a   Osculati, Francesco ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b GSK   (Italy)

Author keywords

Drug addiction; Immunohistochemistry; Neurofilament; Neurotransmitter; Ultrastructure; VTA

Indexed keywords

ANTIBODY; COCAINE; MORPHINE; NEUROFILAMENT PROTEIN; NEUROFILAMENT PROTEIN 160; NEUROFILAMENT PROTEIN 200; NEUROFILAMENT PROTEIN 68; NICOTINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DENSITY; DOPAMINERGIC NERVE CELL; ELECTRON MICROSCOPY; GLIA CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MEASUREMENT; MICRODENSITOMETRY; NERVE DEGENERATION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; RAT; SUBSTANTIA NIGRA; ULTRASTRUCTURE; VENTRAL TEGMENTUM;

ANIMALS; AXONS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON; NEUROFILAMENT PROTEINS; NICOTINE; NICOTINIC AGONISTS; RATS; RATS, WISTAR; VENTRAL TEGMENTAL AREA;

EID: 18744363605     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2002.02167.x     Document Type: Article

References (21)

1. Altman, J., Everitt, B.J., Glautier, S., Markou, A., Nutt, D., Oretti, R., Phillips, G.D. & Robbins, T.W. (1996) The biological, social, and clinical bases of drug addiction: Commentary and debate. Psychopharmacology, 125, 285-345.
2. Balfour, D.J.K., Benwell, M.E.M., Birrel, C.E., Kelly, R.J. & Al-Aloul, M. (1998) Sensitization of mesoaccumbens dopamine response to nicotine. Pharmacol. Biochem. Behav., 4, 1021-1030.
3. Beitner-Johnson, D., Guitart, X. & Nestler, E.J. (1992) Neurofilaments proteins and the mesolimbic dopamine system: Common regulation by chronic morphine and chronic cocaine in the ventral tegmental area. J. Neurosci., 12, 2165-2176.
4. Bunnemann, B., Terron, A., Zantedeschi, V., Merlo Pich, E. & Chiamulera, C. (2000) Chronic nicotine treatment decrease neurofilament immunoreactivity in the rat ventral tegmental area. Eur. J. Pharmacol., 393, 249-253.
5. Calabresi, P., Lacey, M.G. & North, R.A. (1989) Nicotine excitation of rat ventral tegmental neurons in vitro studied by intracellular recording. Br. J. Pharmacol., 98, 135-140.
6. Guitart, X., Beitner-Johnson, D., Marby, D.W., Kosten, T.A. & Nestler, E.J. (1992) Fischer and Lewis rat strains differ in basal levels of neurofilament proteins and their regulation by chronic morphine in the mesolimbic dopamine system. Synapse, 12, 242-253.
7. Guitart, X., Kogan, J.H., Berhow, M., Terwilliger, R.Z., Aghajanian, G.K. & Nestler, E.J. (1993a) Lewis and Fischer rat strains display differences in biochemical, electrophysiological and behavioral parameters: Studies in the nucleus accumbens and locus coeruleus of drug naïve and morphine-treated animals. Brain Res., 611, 7-17.
8. Guitart, X., Lumeng, L., Li, T. & Nestler, E.J. (1993b) Alcohol-preferring and non-preferring rats display different levels of neurofilament proteins in the ventral tegmental area. Alcohol. Clin. Exp. Res., 17, 580-585.
9. Hisanaga, S., Matsuoka, Y., Nishsizawa, K., Saito, T., Inagaki, M. & Hirokawa, N. (1994) Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and NF-H by catalytic subunit of cAMP-dependent protein kinase. Mol. Biol. Cell, 5, 161-172.
10. Koob, G.F. (1992) Drug of abuse: Anatomy, pharmacology and function of reward pathways. Trends Pharmacol., 13, 177-184.
11. Kreek, M.J. & Koob, G.F. (1998) Drug dependence: Stress and dysregulation of brain reward pathways. Drug Alcohol Dependence, 51, 23-47.
12. LeMoal, M. & Simon, H. (1991) Mesocorticolimbic dopaminergic network: Functional roles. Physiol. Rev., 71, 155-234.
13. McGehee, D.S., Heath, M.J.S., Gelber, S., Devay, P. & Role, L.W. (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science, 269, 1692-1696.
14. Merlo Pich, E., Pagliusi, S.R., Tessari, M., Talabot-Ayer, D., Hooft van Huijsduijnen, R. & Chiamulera, C. (1997) Common neural substrates for the addictive properties of nicotine and cocaine. Science, 275, 83-86.
15. Miserendino, M.J.D., Guitart, X., Terwilliger, R.Z., Chi, S. & Nestler, E.J. (1993) Individual differences in locomotor activity are associated with levels of tyrosine hydroxylase and neurofilaments proteins in the ventral tegmental area of Sprague-Dawley rats. Mol. Cell. Neurosci., 4, 440-448.
16. Nestler, E.J., Guitart, X., Ortiz, J. & Trevisan, L. (1994) Second messenger and protein phosphorylation mechanisms underlying possible genetic vulnerability to alcoholism. Ann. NY Acad. Sci., 708, 108-118.
17. Nestler, E.J., Hope, B.T. & Widnell, K.L. (1993) Drug addiction: A model for the molecular basis of neural plasticity. Neuron, 11, 995-1006.
18. Paxinos, G. & Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney, Australia.
19. Shaw, G., Osborn, M. & Weber, K. (1986) Reactivity of a panel of neurofilament antibodies on phosphorylated and dephosphorylated neurofilaments. Eur. J. Cell Biol., 42, 1-9.
20. Smith, K.M., Mitchell, S.N. & Joseph, M.H. (1991) Effects of chronic and subchronic nicotine on tyrosine hydroxylase activity in noradrenergic and dopaminergic neurons in the rat brain. J. Neurochem., 57, 1750-1756.
21. Zuoshang, X., Dennis, L.-Y. & Cleveland, D.W. (1994) Neuronal intermediate filaments: New progress on an old subject. Curr. Opin. Neurobiol., 4, 655-661.