Antiapoptotic mechanisms of idoxifene on cultured rat hepatocytes undergoing oxidative stress

Chinese Pharmaceutical Journal

Volumn 40, Issue 4, 2005, Pages 278-281

  Zhou, Ya Jun ^a   Chen, Hong Shan ^a   Sha, Bao Xi ^a  

^a NANTONG MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; Hepatic fibrosis; Idoxifene; Oxidative stress

Indexed keywords

ASSAYS; ELECTROPHORESIS; ENZYMES; PROTEINS; STRESS ANALYSIS;

ESTROGENS; HEPATOCYTES; OXIDATIVE STRESS;

OXIDATION;

ANTIESTROGEN; CASPASE 3; IDOXIFENE; NITRILOTRIACETATE IRON; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; INCUBATION TIME; LIVER CELL CULTURE; NONHUMAN; OXIDATIVE STRESS; RAT; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

EID: 18744362680     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Hirsimaki P, Altonen A, Mantyla E. Toxicity of antiestrogens [J]. Breast J, 2002, 8: 92.
2. Yerushalmi B, Dahl R, Devereaux MW, et al. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition [J]. Hepatolagy, 2001, 33: 616.
3. Faouzi S, Burckhardt BE, Hanson JC, et al. Anti-Fas induces hepatic chemokines and promotes inflammation by an NF-kB-independent, caspase-3-dependent pathway[J]. J Biol Chem, 2001, 276: 49077.
4. Canbay A, Guicciardi ME, Higuchi H, et al. Cathepsin B inactivation attenuates hepaticinjury and fibrosis during cholestasis [J]. J Clin Invest, 2003, 112: 152.
5. Liu Y, Shimizu I, Omoya T, et al. Protective effect of estradiol on hepatocytic oxidative damage [J]. World J Gastroentrol, 2002, 8: 363.
6. Omoya T, Shimizu I, Zhou Y, et al. Effects of idoxifene and estradiol on NF-kB activationin cultured rat hepatocytes undergoing oxidative stress[J]. Liver, 2001, 21: 183.
7. Zhou Y, Shimizu I, Lu GM, et al. Hepatic stellate cells contain the functional estrogen receptor β but not the estrogen receptor α in male and female rats[J]. Biochem Biophys Res Commun, 2001, 286: 1059.
8. Fan M, Goodwin ME, Chambers TC, et al. The c-Jun NH2-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine [J]. Cancer Res, 2001, 61: 4450.
9. Choudhury JA, Ruessel CL, Randhawa S, et al. Differential induction of Nuclear Factor-kB and Activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation [J]. Mol Boil Cell, 2003, 44: 1334.