Various protein kinases regulate human sperm acrosome reaction and the associated phosphorylation of Tyr residues and of the Thr-Glu-Tyr motif

Molecular Human Reproduction

Volumn 11, Issue 3, 2005, Pages 211-221

  Liguori, Lavynia ^a,b   de Lamirande, E ^b   Minelli, A ^a   Gagnon, C ^b  

^a UNIVERSITY OF PERUGIA   (Italy)

^b ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

Lysophosphatidylcholine; Protein phosphorylation; Signal transduction; Sperm function; Spermatozoa

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; LYSOPHOSPHATIDYLCHOLINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE INHIBITOR; PROTEIN SH2; PROTEIN TYROSINE KINASE; THREONYLGLUTAMYLTYROSINE; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ACROSOME REACTION; ARTICLE; CONTROLLED STUDY; DENSITOMETRY; ENZYME MECHANISM; ENZYME REGULATION; EXOCYTOSIS; FERTILIZATION; FETUS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOBLOTTING; MALE; NORMAL HUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPERMATOZOON CAPACITATION; TIME;

ACROSOME REACTION; AMINO ACID MOTIFS; HUMANS; LYSOPHOSPHATIDYLCHOLINES; MALE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; SPERMATOZOA; TYROSINE;

EID: 18644383152     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/gah154     Document Type: Article

References (52)

1. Aitken RJ, Buckingham DW and Fang HG (1993) Analysis of the responses of human spermatozoa to A23187 employing a novel technique for assessing the acrosome reaction. J Androl 14,132-141.
2. Aitken RJ, Paterson M, Fisher H, Buckingham DW and van Duin M (1995) Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in human sperm function. J Cell Sci 180,2017-2025.
3. Aquila S, Sisci D, Gentile M, Middea E, Catalano S, Carpino A, Rago V and Andò S (2004) Estrogen receptor (ER)a and ERb are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway. J Clin Endocrinol Metab 89,1443-1451.
4. Baldi E, Luconi M, Bonaccorsi L, Muratori M and Forti G (2000) Intracellular events and signaling pathways involved in sperm acquisition of fertilizing capacity and acrosome reaction. Front Biosci 5,110-123.
5. Biggers JD, Whitten WK and Whittingham DG (1971) The culture of mouse embryos in vitro. In Daniel JC (ed.), Methods in Mammalian Embryology. W.H. Freeman USA, San Fransisco, pp. 86-116.
6. Bonaccorsi L, Krausz C, Pecchioli P, Forti G and Baldi E (1998) Progesterone-stimulated intracellular calcium increase in human spermatozoa is protein kinase C-independent. Mol Hum Reprod 4,259-268.
7. Breitbart H, Lax Y, Rotem R and Naor Z (1992) Role of protein kinase C in the acrosome reaction of mammalian spermatozoa. Biochem J 281, 473-476.
8. Burnatowska-Hledin M, Zhao P, Capps B, Poel A, Parmelee K, Mungall C, Sharangpani A and Listenberger L (2000) VACM-1, a cullin gene family member, regulates cellular signaling. Am J Physiol Cell Physiol 279, 266-273.
9. Cross NL, Morales P, Overstreet JW and Hanson FW (1986) Two simple methods for detecting the acrosome reaction in human sperm. Gamete Res 15,29-40.
10. De Jonge CJ, Barratt CLR, Radwanska EWA and Cooke ID (1993) The acrosome reaction-inducing effect of human follicular and oviductal fluid. J Androl 14,359-365.
11. Dolci S, Pellegrini M, Di Agostino S, Geremia R and Rossi P (2001) Signaling through extracellular signal-regulated kinase is required for spermatogonial proliferative response to stem cell factor. J Biol Chem 43, 40225-40233.
12. 2+ stores depletion during human sperm acrosome reaction. Mol Hum Reprod 9,125-131.
13. Du Plessis SS, Page C and Franken DR (2001) The zona pellucida-induced acrosome reaction of human spermatozoa involves extracellular signal-regulated kinase activation. Andrologia. 33,337-342.
14. Du Plessis SS, Page C and Franken DR (2002) Extracellular signal-regulated kinase activation involved in human sperm-zona pellucida binding. Andrologia. 34,55-59.
15. Du Plessis SS, Franken DR, Baldi E and Luconi M (2004) Phosphatidyl-inositol 3-kinase inhibition enhances human sperm motility and sperm-zona pellucida binding. Int J Androl 27,19-26.
16. Fisher HM, Brewis IA, Barratt CL, Cooke ID and Moore HD (1998) Phosphoinositide 3-kinase is involved in the induction of the human sperm acrosome reaction downstream of tyrosine phosphorylation. Mol Hum Reprod 4,849-855.
17. Flesh FM and Gadella BM (2000) Dynamics of the mammalian sperm plasma membrane in the process of fertilization. Biochim Biophys Acta 1469,197-235.
18. Gay B, Suarez S, Caravatti G, Furet P, Meyer T and Schoepfer J (1999) Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer 2, 235-241.
19. Grippo AA, Anderson SH, Chapman DA, Henault NA and Killian GJ (1994) Cholesterol, phospholipid and phospholipase activity of ampullary and isthmic fluid from the bovine oviduct. J Reprod Fertil 102,87-93.
20. Griveau JF, Renard P and Le Lannou D (1994) An in vitro promoting role for hydrogen peroxide in human sperm capacitation. Int J Androl 17, 300-307.
21. Harrison DA, Carr DW and Meizel S (2000) Involvement of protein kinase A and A kinase anchoring protein in the progesterone-initiated human sperm acrosome reaction. Biol Reprod 62,811-820.
22. Herrero MB, de Lamirande E and Gagnon C (1999) Nitric oxide regulates human sperm capacitation and protein tyrosine phosphorylation in vitro. Biol Reprod 61,575-581.
23. Herrero MB, Chatterjiee S, Lefièvre L, de Lamirande E and Gagnon C (2000) Nitric oxide interacts with the cAMP pathway to modulate capacitation of human spermatozoa. Free Radic Biol Med 29,522-536.
24. Herrero MB, de Lamirande E and Gagnon C (2001) Tyrosine nitration in human spermatozoa: a physiological function of peroxynitrite, the reaction product of nitric oxide and superoxide. Mol Hum Reprod 10,913-921.
25. I signalling in human spermatozoa. Mol Hum Reprod 8,326-332.
26. de Lamirande E and Gagnon C (2002) The extracellular signal-regulated kinases (ERK) pathway is involved in human sperm function and modulated by the superoxide anion. Mol Hum Reprod 8,124-135.
27. de Lamirande E and Gagnon C (2003) Redox control of changes in protein sulfhydryl levels during human sperm capacitation. Free Radic Biol Med 35,1271-1285.
28. de Lamirande E, Leclerc P and Gagnon C (1997) Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Mol Hum Reprod 3,175-194.
29. de Lamirande E, Tsai C, Harakat A and Gagnon C (1998) Involvement of reactive oxygen species in human sperm acrosome reaction induced by A23187, lysophosphatidylcholine, and biological fluid ultrafiltrates. J Androl 19,585-594.
30. Leclerc P, de Lamirande E and Gagnon C (1996) cAMP-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility. Biol Reprod 55,684-692.
31. Leclerc P, de Lamirande E and Gagnon C (1997) Regulation of protein tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivates. Free Rad Reprod 22,643-656.
32. Lefièvre L, de Lamirande E and Gagnon C (2002) Activation of protein kinase A during human sperm capacitation and acrosome reaction. J Androl 23,709-716.
33. Leyton L and Saling P (1989) 95 kDa sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Cell 57,1123-1130.
34. Luconi M, Bonaccorsi L, Krausz C, Gervasi G, Forti G and Baldi E (1995) Stimulation of protein tyrosine phosphorylation by platelet-activating factor and progesterone in human spermatozoa. Mol Cell Endocrinol 108, 35-42.
35. Luconi M, Krausz C, Forti G and Baldi E (1996) Extracellular calcium negatively modulated tyrosine phosphorylation and tyrosine kinase activity during capacitation of human spermatozoa. Biol Reprod 55,207-216.
36. Luconi M, Krausz C, Barni T, Vannelli GB, Forti G and Baldi E (1998) Progesterone stimulates p42 extracellular signal-regulated kinase (p42erk) in human spermatozoa. Mol Hum Reprod 4,251-258.
37. Luconi M, Carloni V, Marra F, Ferruzzi P, Forti G and Baldi E (2004) Increased phosphorylation of AKAP by inhibition of phosphatidylinositol 3-kinase enhances human sperm motility through tail recruitment of protein kinase A. J Cell Sci 117,1235-1246.
38. 2 purinoceptor. Biol Reprod 66,429-437.
39. Makranz C, Cohen G, Baron A, Levidor L, Kodama T, Reichert F and Rotshenker S (2004) Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-C gamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages. Neurobiol Dis 2,279-286.
40. Meizel S and Turner KO (1996) Chloride efflux during the progesterone initiated human sperm acrosome reaction is inhibited by lavendustin A, a tyrosine kinase inhibitor. J Androl 17,327-330.
41. 2+ dependent divergences. J Androl 25,573-585.
42. O'Flaherty C, de Lamirande E and Gagnon C (2004) Phosphorylation of the Arginine-X-X-(Serine/Threonine) motif in human sperm proteins during capacitation: modulation and protein kinase A dependency. Mol Hum Reprod 10,355-365.
43. O'Toole CM, Roladan ER and Fraser LR (1996) Protein kinase C activation during progesterone-stimulated acrosomal exocytosis in human spermatozoa. Mol Hum Reprod 12,921-927.
44. Spungin B and Breitbart H (1996) Calcium mobilization and influx during sperm exocytosis. J Cell Sci 109,1947-1955.
45. Stauss CR, Votta TJ and Suarez SS (1995) Sperm motility hyperactivation facilitates penetration of the hamster zona pellucida. Biol Reprod 53,1280-1285.
46. 2+ fluxes in progesterone induced acrosome reaction. Mol Hum Reprod 2,225-232.
47. Thundathil J, de Lamirande E and Gagnon C (2002) Different signal pathways are involved during human sperm capacitation induced by biological and pharmacological agents. Mol Hum Reprod 8,811-816.
48. Thundathil J, de Lamirande E and Gagnon C (2003) Nitric oxide regulates the phosphorylation of the threonine-glutamine-tyrosine motif in proteins of human spermatozoa during capacitation. Biol Reprod 68,1291-1298.
49. Tomes CN, Roggero CM, De Blas G, Saling PM and Mayorga LS (2004) Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis. Dev Biol 265,399-415.
50. Urner F and Sakkas D (2003) Protein phosphorylation in mammalian spermatozoa. Reproduction 125,17-26.
51. Visconti PE, Westbrook VA, Chertihin I, Demarco I, Sleight S and Diekman AB (2002) Novel signaling pathways involved in sperm acquisition of fertilizing capacity. J Reprod Immunol 53,133-150.
52. Yanagimachi R (1994) Mammalian ertilization. In Knobil E and Neill JD (eds), The Physiology of Reproduction. Raven Press, Ltd, New York, pp. 189-317.