Unexpected subtilisin-catalyzed hydrolysis of a sulfinamide bond in preference to a carboxamide bond in N-acyl sulfinamides

Journal of the American Chemical Society

Volumn 127, Issue 18, 2005, Pages 6536-6537

  Mugford, Paul F ^a   Magloire, Vladimir P ^a   Kazlauskas, Romas J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BETA LACTAM DERIVATIVE; BETA SULTAM; CHLOROACETAMIDE; CHLOROACETIC ACID; GLUCOSAMINE; GLYCINE; N CHLORO ACETYL P TOLUENESULFINAMIDE; SERINE PROTEINASE; SUBTILISIN; SUBTILISIN CARLSBERG; SULFINAMIDE; SULFINIC ACID DERIVATIVE; SULFONE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHEMICAL BOND; COMPETITIVE INHIBITION; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

AMIDES; CATALYSIS; HYDROLYSIS; PANCREATIC ELASTASE; STEREOISOMERISM; SUBSTRATE SPECIFICITY; SUBTILISIN; SULFINIC ACIDS; SULFONAMIDES;

EID: 18644365735     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0506105     Document Type: Article

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