Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: Improvement of cell potency

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 21, 2002, Pages 3153-3156

  Chen, Ping ^a   Iwanowicz, Edwin J ^a   Norris, Derek ^a   Gu, Henry H ^a   Lin, James ^a   Moquin, Robert V ^a   Das, Jagabandhu ^a   Wityak, John ^a   Spergel, Steven H ^a   De Fex, Henry ^a   Pang, Suhong ^a   Pitt, Sydney ^a   Shen, Ding Ren ^a   Schieven, Gary L ^a   Barrish, Joel C ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; LCK INHIBITOR; PHENYL GROUP; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LYMPHOCYTE PROLIFERATION; STRUCTURE ACTIVITY RELATION;

CELL DIVISION; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); QUINOXALINES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 18644361826     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00677-7     Document Type: Article

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