Development and applications of injectable poly(ortho esters) for pain control and periodontal treatment

Biomaterials

Volumn 23, Issue 22, 2002, Pages 4397-4404

  Heller, J ^a   Barr, J ^a   Ng, S Y ^b   Shen, H R ^a   Schwach Abdellaoui, K ^b   Gurny, R ^b   Vivien Castioni, N ^b   Loup, P J ^b   Baehni, P ^b   Mombelli, A ^b  

^a AP Pharma   (United States)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Bioerodible polymer; Bupivacaine; Periodontal disease; Poly(ortho ester); Post surgical pain; Tetracycline

Indexed keywords

TOXICOLOGY;

ALCOHOLS; GLASS TRANSITION; MEDICAL IMAGING; MOLECULAR WEIGHT; POLYMERS; SOLVENTS; THERMAL EFFECTS;

BIOMATERIALS;

ACETAL DERIVATIVE; ALCOHOL DERIVATIVE; BUPIVACAINE; MACROGOL; MEPIVACAINE; POLY(ORTHO ESTER); POLYMER; TRIETHYLENE GLYCOL;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; GLASS TRANSITION TEMPERATURE; HYDROPHILICITY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; WOUND HEALING;

ANESTHETICS, LOCAL; ANIMALS; BIOCOMPATIBLE MATERIALS; BUPIVACAINE; DOGS; DRUG CARRIERS; FATTY ALCOHOLS; GINGIVA; GLASS; HUMANS; INJECTIONS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PAIN; PERIODONTAL DISEASES; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; TEMPERATURE; TETRACYCLINE; TIME FACTORS;

EID: 18544369924     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(02)00180-1     Document Type: Article

References (13)

1. Preparation of poly(ortho esters) by the reaction of ketene acetals and diols
2. Poly (ortho esters) by the addition of diols to a diketene acetal
3. Poly(ortho esters)
4. Synthesis and erosion studies of self-catalyzed poly(ortho ester)s
5. Hydrolysis and erosion studies of autocatalyzed poly(ortho esters) containing lactoyl-lactyl acid dimers
6. Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery
7. Control of molecular weight for auto-catalyzed poly(ortho esters) obtained by polycondensation reaction
8. Development of a poly(ortho ester) prototype with latent acid in the polymer backbone for 5-fluorouracil delivery
9. Optimization of a novel bioerodible device based on autocatalyzed poly(ortho ester) for controlled delivery of tetracycline to periodontal pocket
10. Properties, absorption and disposition of local anesthetic agents
11. Local delivery of antimicrobial agents for the treatment of periodontal diseases
12. Periodontal infections and treatment