Somatic mutant frequency at the HPRT locus in children associated with a pediatric cancer cluster linked to exposure to two superfund sites

Environmental and Molecular Mutagenesis

Volumn 45, Issue 4, 2005, Pages 339-345

  Vacek, Pamela M ^a   Messier, Terri ^a   Rivers, Jami ^a   Sullivan, Linda ^a   O'Neill, J Patrick ^a,b   Finette, Barry A ^a,b  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VERMONT   (United States)

Author keywords

Biomarker; Children; Genotoxic exposure; HPRT gene; Mutant frequency

Indexed keywords

BIOLOGICAL MARKER; DRINKING WATER; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; CANCER INCIDENCE; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GENE LOCUS; GENOTOXICITY; HPRT GENE; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; SIBLING; SOMATIC MUTATION; UNITED STATES; WATER CONTAMINATION;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHILD; CLUSTER ANALYSIS; ENVIRONMENTAL EXPOSURE; FEMALE; HAZARDOUS WASTE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INCIDENCE; MALE; MUTATION; NEOPLASMS; NEW JERSEY; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 18444403173     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.20101     Document Type: Article

References (57)

1. Akiyama M, Kyoizumi S, Hirai Y, Hakoda M, Nakamura N, Awa AA. 1990. Studies on chromosome aberrations and HPRT mutations in lymphocytes and GPA mutation in erythrocytes of atomic bomb survivors. Prog Clin Biol Res 340C:69-80.
2. Albertini RJ, Castle KL, Borcherding WR. 1982. T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood. Proc Natl Acad Sci USA 79:6617-6621.
3. Albertini RJ, Hayes RB. 1997. Somatic cell mutations in cancer epidemiology. In: Toniolo P, Boffetta P, Shuker DEG, Rothman N, Hulka B, Pearce N, editors. Applications of biomarkers in cancer epidemiology, 142 ed. Lyon: International Agency for Research on Cancer. p159-184.
4. Albertini RJ, Sram RJ, Vacek PM, Lynch J, Nicklas JA, van Sittert NJ, Boogaard PJ, Henderson RF, Swenberg JA, Tales AD, Ward JB Jr, Wright M, Ammenheuser MM, Binkova B, Blackwell W, de Zwart FA, Krako D, Krone J, Megens H, Musilova P, Rajska G, Ranasinghe A, Rosenblatt JI, Rossner P, Rubes J, Sullivan L, Upton P, Zwinderman AH. 2003. Biomarkers in Czech workers exposed to 1,3-butadiene: a transitional epidemiologic study. Res Rep Health Eff Inst 116:1-141.
5. Bearer CF. 1995. How are children different from adults? Environ Health Perspect 103(Suppl 6):7-12.
6. Bearer CF. 1998. Biomarkers in pediatric environmental health: a cross-cutting issue. Environ Health Perspect 106(Suppl 3):813-816.
7. Becker R, Nikolova T, Wolff I, Lovell D, Huttner E. Foth H. 2001. Frequency of HPRT mutants in humans exposed to vinyl chloride via an environmental accident. Mutat Res 494:87-96.
8. Berry M, Haltmeier P. 1997. Childhood cancer incidence health consultation: a review and analysis of cancer registry data, 1979-1995 for Dover Township (Ocean County), New Jersey-final technical report. Trenton, NJ: New Jersey Department of Health and Senior Services, Division of Epidemiology, Environmental and Occupational Health, Consumer and Environmental Health Services.
9. Bigbee WL, Day RD, Grant SG, Keohavong P, Xi L, Zhang L, Ness RB. 1999. Impact of maternal lifestyle factors on newborn HPRT mutant frequencies and molecular spectrum: initial results from the Prenatal Exposures and Preeclampsia Prevention (PEPP) study. Mutat Res 431:279-289.
10. Branda RF, O'Neill JP, Sullivan LM, Albertini RJ. 1991. Factors influencing mutation at the hprt locus in T-lymphocytes: women treated for breast cancer. Cancer Res 51:6603-6607.
11. Branda RF, Sullivan LM, O'Neill JP, Falta MT, Nicklas JA, Hirsch B, Vacek PM, Albertini RJ. 1993. Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations. Mutat Res 285:267-279.
12. Caggana M, Liber HL, Mauch PM, Coleman CN, Kelsey KT. 1991. In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients. Environ Mol Mutagen 18:6-13.
13. Calvert GM, Talaska G, Mueller CA, Ammenheuser MM, Au WW, Fajen JM, Fleming LE, Briggle T, Ward E. 1998. Genotoxicity in workers exposed to methyl bromide. Mutat Res 417:115-128.
14. Cole J, Arlett CF, Geeen MHL, James SE, Henderson L, Cole H, Sala-Trepat M, Benzi R, Price ML, Bridges BA. 1989. Measurement of mutant frequency to 6-thioguanine resistance in circulating T-lymphocytes for human population monitoring. In: Jolles G, Cordier A, editors. New trends in genetic risk assessment. London: Academic Press, p 175-203.
15. Cole J, Skopek TR. 1994. International Commission for Protection Against Environmental Mutagens and Carcinogens: working paper no. 3-somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutat Res 304:33-105.
16. Cole J, Arlett CF, Green MH, Holdsworth D, Tawn EJ, Bridges BA. 1995. Mutant frequencies in workers at the Sellafield installation. Health Phys 68:388-393.
17. Cole J, Green MH, Bridges BA, Waugh AP, Beare DM, Henshaw D, Last R, Liu Y, Cortopassi G. 1996. Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home. Radiat Res 145:61-69.
18. Cole J, Beare DM, Waugh AP, Capulas E, Aldridge KE, Arlett CF, Green MH, Crum JE, Cox D, Garner RC, Dingley KH, Martin EA, Podmore K, Heydon R, Farmer PB. 1997. Biomonitoring of possible human exposure to environmental genotoxic chemicals: lessons from a study following the wreck of the oil tanker Braer. Environ Mol Mutagen 30:97-111.
19. Dempsey JL, Seshadri RS, Morley AA. 1985. Increased mutation frequency following treatment with cancer chemotherapy. Cancer Res 45:2873-2877.
20. Fagliano JA, Berry M, Kohler BA, Klotz JB, Imtiaz R. 2001. Case-control study of childhood cancers in Dover Township (Ocean County), New Jersey: final technical report. Trenton, NJ: New Jersey Department of Health and Senior Services, Division of Epidemiology, Environmental and Occupational Health, Consumer and Environmental Health Services.
21. Farmer PB, Sepai O, Lawrence R, Autrup H, Sabro Nielsen P, Vestergard AB, Waters R, Leuratti C, Jones NJ, Stone J, Baan RA, van Delft JH, Steenwinkel MJ, Kyrtopoulos SA, Souliotis VL, Theodorakopoulos N, Bacalis NC, Natarajan AT, Tales AD, Haugen A, Andreassen A, Ovrebo S, Shuker DE, Amaning KS, Castelain P, et al. 1996. Biomonitoring human exposure to environmental carcinogenic chemicals. Mutagenesis 11:363-381.
22. Finette BA, Sullivan LM, O'Neill JP, Nicklas JA, Vacek PM, Albertini RJ. 1994. Determination of hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age. Mutat Res 308:223-231.
23. Finette BA, Poseno T, Vacek PM, Albertini RJ. 1997. The effects of maternal cigarette smoke exposure on somatic mutant frequencies at the hprt locus in healthy newborns. Mutât Res 377:115-123.
24. Finette BA, O'Neill JP, Vacek PM, Albertini RJ. 1998. Gene mutations with characteristic deletions in cord blood T lymphocytes associated with passive maternal exposure to tobacco smoke. Nat Med 4:1144-1151.
25. Hakoda M, Akiyama M, Kyoizumi S, Awa AA, Yamakido M, Otake M. 1988. Increased somatic cell mutant frequency in atomic bomb survivors. Mutat Res 201:39-48.
26. Hayes RB, Xi L, Bechtold WE, Rothman N, Yao M, Henderson R, Zhang L, Smith MT, Zhang D, Wiemels J, Dosemeci M, Yin S, O'Neill JP. 1996. hprt mutation frequency among workers exposed to 1,3-butadiene in China. Toxicology 113:100-105.
27. Hayes RB, Zhang L, Yin S, Swenberg JA, Xi L, Wiencke J, Bechtold WE, Yao M, Rothman N, Haas R, O'Neill JP, Zhang D, Wiemels J, Dosemeci M, Li G, Smith MT. 2000. Genotoxic markers among butadiene polymer workers in China. Carcinogenesis 21:55-62.
28. Hazardous Site Health Evaluation Program. 2001a. Public health assessment, Ciba-Geigy Corporation. Trenton, NJ: New Jersey Department of Health and Senior Services, Division of Epidemiology, Environmental and Occupational Health, Consumer and Environmental Health Services.
29. Hazardous Site Health Evaluation Program. 2001b. Public health assessment, Reich Farm, Dover Township, Ocean County, New Jersey, Trenton, NJ: New Jersey Department of Health and Senior Services, Division of Epidemiology, Environmental and Occupational Health, Consumer and Environmental Health Services.
30. Hazardous Site Health Evaluation Program. 2001c. Public health consultation, drinking water quality analysis, March 1996 to June 1999, United Water Toms River, Dover Township, Ocean County, New Jersey. Trenton, NJ: New Jersey Department of Health and Senior Services, Division of Epidemiology, Environmental and Occupational Health, Consumer and Environmental Health Services.
31. Hirai Y, Kusunoki Y, Kyoizumi S, Awa AA, Pawel DJ, Nakamura N, Akiyama M. 1995. Mutant frequency at the HPRT locus in peripheral blood T-lymphocytes of atomic bomb survivors. Mutat Res 329:183-196.
32. Hirota H, Kubota M, Hashimoto H, Adachi S, Matsubara K, Kuwakado K, Akiyama Y, Tsutsui T, Mikawa H. 1993. Analysis of hprt gene mutation following anti-cancer treatment in pediatric patients with acute leukemia. Mutat Res 319:113-120.
33. Jones IM, Thomas CB, Tucker B, Thompson CL, Pleshanov P, Voroblsova I, Moore DH II. 1995. Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans. Mutat Res 338:129-139.
34. Kyrtopoulos SA, Georgiadis P, Autrup H, Demopoulos NA, Farmer P, Haugen A, Katsouyanni K. Lambert B, Ovrebo S, Sram R, Stephanou G, Topinka J, Stefanou G, Demopoulos N. 2001. Biomarkers of genotoxicity of urban air pollution: overview and descriptive data from a molecular epidemiology study on populations exposed to moderate-to-low levels of polycyclic aromatic hydrocarbons-the AULIS project. Mutat Res 496:207-228.
35. Landrigan PJ, Carlson JE, Bearer CF, Cranmer JS, Bullard RD, Etzel RA, Groopman J, McLachlan JA, Perera FP, Reigart JR, Robison L, Schell L, Suk WA. 1998. Children's health and the environment: a new agenda for prevention research. Environ Health Perspect 106(Suppl 3):787-794.
36. Manchester DK, Nicklas JA, O'Neill JP, Lippert MJ, Grant SG, Langlois RG, Moore DH III, Jensen RH, Albertini RJ, Bigbee WL. 1995. Sensitivity of somatic mutations in human umbilical cord blood to maternal environments. Environ Mol Mutagen 26:203-212.
37. Messing K, Bradley WE. 1985. In vivo mutant frequency rises among breast cancer patients after exposure to high doses of gamma-radiation. Mutat Res 152:107-112.
38. Morgan DL, Dunnick JK, Goehl T, Jokinen MP, Matthews HB, Zeiger E, Mennear JH. 1994. Summary of the National Toxicology Program benzidine dye initiative. Environ Health Perspect 102(Suppl 2):63-78.
39. Morley AA, Trainor KJ, Seshadri R, Ryall RG. 1983. Measurement of in vivo mutations in human lymphocytes. Nature 302:155-156.
40. National Toxicology Program. 2001. Toxicology and carcinogenesis studies of acrylonitrile in B6C3F1 mice. Reseach Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service.
41. National Toxicology Program. 2002. Report on carcinogens. Research Triangle Park, NJ: U.S. Department of Health and Human Services, Public Health Service.
42. Nicklas JA, Falta MT, Hunter TC, O'Neill JP, Jacobson-Kram D, Williams JR, Albertini RJ. 1990. Molecular analysis of in vivo hprt mutations in human T lymphocytes: V, effects of total body irradiation secondary to radioimmunoglobulin therapy (RIT). Mutagenesis 5:461-468.
43. O'Neill JP, McGinniss MJ, Berman JK, Sullivan LM, Nicklas JA, Albertini RJ. 1987. Refinement of a T-lymphocyte cloning assay to quantify the in vivo thioguanine-resistant mutant frequency in humans. Mutagenesis 2:87-94.
44. Palmer RG, Smith-Burchnell CA, Pelton BK, Hylton W, Denman AM. 1988. Use of T cell cloning to detect in vivo mutations induced by cyclophosphamide. Arthritis Rheum 31:757-761.
45. Perera FP, Tang DL, O'Neill JP, Bigbee WL, Albertini RJ, Santella R, Ottman R, Tsai WY, Dickey C, Mooney LA, et al. 1993. HPRT and glycophorin A mutations in foundry workers: relationship to PAH exposure and to PAH-DNA adducts. Carcinogenesis 14:969-973.
46. Perera F, Hemminki K, Jedrychowski W, Whyatt R, Campbell U, Hsu Y, Samella R, Albertini R, O'Neill JP. 2002. In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. Cancer Epidemiol Biomarkers Prev 11(10 Pt 1):1134-1137.
47. Rice SC, Vacek P, Homans AH, Messier T, Rivers J, Kendall H, Finette BA. 2004. Genotoxicity of therapeutic intervention in children with acute lymphocytic leukemia. Cancer Res 64:4464-4471.
48. Richardson SD, Collette TW, Price PC, Genicola FA, Jenks JW, Thruston AD Jr, Ellington JJ. 1999. Identification of drinking water contaminants in the course of a childhood cancer investigation in Toms River, New Jersey. J Expo Anal Environ Epidemiol 9:200-216.
49. Sala-Trepat M, Cole J, Green MH, Rigaud O, Vilcoq JR, Moustacchi E. 1990. Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients: III, measurement of mutant frequency to 6-thioguanine resistance. Mutagenesis 5:593-598.
50. Seifert AM, Bradley WE, Messing K. 1987. Exposure of nuclear medicine patients to ionizing radiation is associated with rises in HPRT-mutant frequency in peripheral T-lymphocytes. Mutat Res 191:57-63.
51. Seifert AM, Deniers C, Dubeau H, Messing K. 1993. HPRT-mutant frequency and lymphocyte characteristics of workers exposed to ionizing radiation on a sporadic basis: a comparison of two exposure indicators, job title and dose. Mutat Res 319:61-70.
52. Tates AD, Grummt T, Tornqvist M, Farmer PB, van Dam FJ, van Mossel H, Schoemaker HM, Osterman-Golkar S, Uebel C, Tang YS, et al. 1991. Biological and chemical monitoring of occupational exposure to ethylene oxide. Mutat Res 250:483-497.
53. Tates AD, Grummt T, van Dam FJ, de Zwart F, Kasper FJ, Rolhe R, Stirn H, Zwinderman AH, Natarajan AT. 1994. Measurement of frequencies of HPRT mutants, chromosomal aberrations, micronuclei, sister-chromatid exchanges and cells with high frequencies of SCEs in styrene/dichloromethane-exposed workers. Mutat Res 313:249-262.
54. Tates AD, Boogaard PJ, Darroudi F, Natarajan AT, Caubo ME, van Sittert NJ. 1995. Biological effect monitoring in industrial workers following incidental exposure to high concentrations of ethylene oxide. Mutat Res 329:63-77.
55. Vodicka P, Bastlova T, Vodickova L, Peterkova K, Lambert B, Hemminki K. 1995. Biomarkers of styrene exposure in lamination workers: levels of O6-guanine DNA adducts, DNA strand breaks and mutant frequencies in the hypoxanthine guanine phosphoribosyltransferase gene in T-lymphocytes. Carcinogenesis 16:1473-1481.
56. Vodicka P, Stetina R, Koskinen M, Soucek P, Vodickova L, Hlavac P, Kuricova M, Necasova R, Hemminki K. 2002. New aspects in the biomonitoring of occupational exposure to styrene. Int Arch Occup Environ Health 75(Suppl):S75-S85.
57. Zanesi N, Mognato M, Pizzato M, Viezzer C, Ferri G, Celotti L. 1998. Determination of HPRT mutant frequency and molecular analysis of T-lymphocyte mutants derived from coke-oven workers. Mutat Res 412:177-186.