Thrittene, homologous with somatostatin-28(1-13), is a novel peptide in mammalian gut and circulation

Endocrinology

Volumn 143, Issue 7, 2002, Pages 2599-2609

  Ensinck, John W ^a   Baskin, Denis G ^a,b,c   Vahl, Torsten P ^f   Vogel, Robin E ^a   Laschansky, Ellen C ^a   Francis, Bruce H ^a,g   Hoffman, Ross C ^d,h   Krakover, Jonathan D ^d,i   Stamm, Michael R ^d   Low, Malcolm J ^e   Rubinstein, Marcelo ^e,j,k   Otero Corchon, Veronica ^e   D'Alessio, David A ^f  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^d ZYMOGENETICS INC   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f UNIVERSITY OF CINCINNATI   (United States)

^g JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

ⁱ Upstate Inc   (United States)

^j INSTITUTO DE INVESTIGACIONES EN INGENIERÍA GENÉTICA Y BIOLOGÍA MOLECULAR   (Argentina)

^k UNIVERSIDAD DE BUENOS AIRES   (Argentina)

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Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; LYSINE; SOMATOSTATIN 28; THRITTENE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CLINICAL ARTICLE; GENE DELETION; GENE DUPLICATION; GENE TARGETING; HUMAN; IMMUNOCYTOCHEMISTRY; INTESTINE BLOOD FLOW; INTESTINE CELL; MALE; MULTIGENE FAMILY; NEUROTRANSMITTER RELEASE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 18444402463     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.143.7.8904     Document Type: Article

References (32)

1. Somatostatin- and urotensin II-related peptides: Molecular diversity and evolutionary perspectives
2. Nucleotide and amino acid sequence comparisons of preprosomatostatins
3. A cortical neuropeptide with neuronal depressant and sleep-modulating properties
4. Cortistatin: A member of the somatostatin neuropeptide family with distinct physiological functions
5. General aspects of the biology and function of somatostatin
6. Somatostatin and its receptor family
7. Processing and intracellular targeting of prosomatostatin-derived peptides: The role of mammalian endoproteases
8. Characterization of an endoprotease from rat small intestinal mucosal secretory granules which generates somatostatin-28 from prosomatostatin by cleavage after a single arginine residue
9. Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex
10. Relationship between endo- and exopeptidases in a processing enzyme system: Activation of an endoprotease by the aminopeptidase B-like activity in somatostatin-28 convertase
11. Direct role of furin in mammalian prosomatostatin processing
12. Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role of the endoproteases furin, PC1, and PC2
13. A high molecular weight form of somatostatin-28 (1-12)-like immunoreactive substance without somatostatin-14 immunoreactivity in the rat pancreas. Evidence that somatostatin-14 synthesis can occur independently of somatostatin-28
14. Peptides derived from cleavage of prosomatostatin at carboxyl- and amino-terminal segments. Characterization of tissue and secreted forms in the rat
15. Differential processing of hormone precursor. Independent production of somatostatins 14 and 28 in transfected neuroblastoma 2A cells
16. Processing and secretion of prosomatostatin by the pig pancreas
17. Circulating prosomatostatin-derived peptides: Differential responses to food ingestion
18. Endogenous somatostatin-28 modulates postprandial instain secretion. Immunoneutralization studies in baboons
19. Identification of cellular prosomatostatin and nonsomatostatin peptides derived from its amino terminus
20. Seven peptides derived from pro-somatostatin in rat brain
21. Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
22. Distribution of somatostatin-14 and somatostatin-28 gastrointestinal-pancreatic cells of rats and humans
23. Somatostatin in epithelial cells of intestinal mucosa is present primarily as somatostatin 28
24. The distribution and characterization of somatostatin-like immunoreactivity in epithelial cells, submucosa, and muscle of the rat stomach and intestine
25. Multiple forms of immunoreactive somatostatin: Comparison of distribution in neural and nonneural tissues and portal plasma of the rat
26. Distribution and characterisation of immunoreactive somatostatin in human gastrointestinal tract
27. Distribution and molecular forms of peptides containing somatostatin immunodeterminants in extracts from the entire gastrointestinal tract of man and pig
28. Evidence for biosynthesis and differential post-translational proteolytic processing of different (pre)prosomatostatins in pancreatic islets
29. Immunohistochemical distribution of pro-somatostatin-related peptides in cerebral cortex
30. An immunohistochemical characterization of somatostatin-28 and somatostatin-281-12 in monkey prefrontal cortex
31. The new biology of gastrointestinal hormones
32. Suppression of food intake by Somatostatin-28(1-13) a novel gut peptide