Dipeptide sulfonamides as endothelin ETA/ETB receptor antagonists

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 5, 2002, Pages 464-469

  Ksander, Gary M ^a   Shetty, Suraj S ^a   DelGrande, Dominick ^a   Balwierczak, Joseph L ^a   Bruseo, Charles W ^a   Savage, Paula ^a   DeJesus, Reynalda ^a   Yuan, Andrew ^a   Webb, Randy L ^a   Jeng, Arco Y ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

CGS 31398; ETA receptor; ETB receptor; Receptor antagonists; SB 209670

Indexed keywords

3 (2 CARBOXYMETHOXY 4 METHOXYPHENYL) 1 (3,4 METHYLENEDIOXYPHENYL) 5 PROPOXY 2 INDANCARBOXYLIC ACID; CGS 31398; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; IODINE 125; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; SARAFOTOXIN S6C; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA; CHO CELL; CONFERENCE PAPER; CONTROLLED STUDY; DOG; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; IC 50; KIDNEY VASCULAR RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; RECEPTOR AFFINITY; SAPHENOUS VEIN; SPECIES DIFFERENCE; VASCULAR RING; VENOCONSTRICTION;

ANIMALS; AORTA, THORACIC; CHO CELLS; CRICETINAE; DIPEPTIDES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; ORGAN CULTURE TECHNIQUES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; SULFONAMIDES; VASOCONSTRICTION;

EID: 18444364971     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-028     Document Type: Conference Paper

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