Inhibition of cholesterol synthesis causes both hypercholesterolemia and hypocholesterolemia in hamsters

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 12, 2002, Pages 1577-1582

  Sawada, Masae ^a   Matsuo, Masahiko ^a   Seki, Jiro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

FR194738; Pravastatin, HMG CoA reductase; Squalene epoxidase, cholesterol

Indexed keywords

CHOLESTEROL; ENZYME INHIBITOR; FR 194738; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; N ETHYL N (6,6 DIMETHYL 2 HEPTEN 4 YNYL) 3 [2 METHYL 2 (3 THIENYLMETHOXY)PROPYLOXY]BENZYLAMINE; PRAVASTATIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; BENZYLAMINE DERIVATIVE; HYPOCHOLESTEROLEMIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; ENZYME ACTIVITY; HAMSTER; HYPERCHOLESTEROLEMIA; HYPOCHOLESTEROLEMIA; INHIBITION KINETICS; LIPID METABOLISM; MALE; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; ENZYMOLOGY; SYRIAN HAMSTER;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BENZYLAMINES; CHOLESTEROL, HDL; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HYPERCHOLESTEROLEMIA; MALE; MESOCRICETUS; PRAVASTATIN;

EID: 1842870848     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.1577     Document Type: Article

References (39)

1. Anderson K. M., Castelli W. P., Levy D., JAMA, 257, 2176-2180 (1987).
2. Lipid Research Clinics Program, JAMA, 251, 351-374 (1984).
3. Blankenhorn D. H., Hodis H. N., West J. Med, 159, 172-179 (1993).
4. Rodwell V. W. Nordstrom J. L, Mistschelen J. J., Adv. Lipid Res., 14, 1-74 (1976).
5. Grundy S. M., N. Engl. J. Med., 319, 24-33 (1988).
6. Folkers K., Langsjoen P., Willis R., Richardson P., Xia L., Ye C., Tamagawa H., Proc. Natl. Acad. Sci. U.S.A., 87, 8931-8934 (1990)
7. Ghirlanda G., Oradei A., Manto A., Lippa S., Uccioli L., Caputo S., Greco A. V., Littarru G. P., J. Clin. Pharmacol., 33, 226-229 (1993).
8. Brown M. S., Goldstein J. L., J Lipid Res., 21, 505-517 (1980).
9. Fujioka T., Nara F., Tsujita Y., Fukushige J., Fukami M., Kuroda M., Biochim. Biophys. Acta, 1254, 7-12 (1995).
10. Hidaka Y., Satoh T., Kamei T., J. Lipid Res., 31, 2087-2094 (1990)
11. Sawada M., Matsuo M, Hagihara H, Tenda N., Nagayoshi A., Okumura H, Washizuka K., Seki J, Goto T., Eur J. Pharmacol., 431, 11-16 (2001).
12. Sawada M, Hagihara H., Washizuka K., Okumura H., Seki J., Tanaka H., Atherosclerosis, 134, 60-61 (1997)
13. Cighetti G., Bosisio E., Galli G., Galli K M, Life Sci., 33, 2483-2488 (1983).
14. Satoh T., Hidaka Y., Kamei T., J. Lipid Res., 31, 2095-2101 (1990).
15. Tai H, Bloch K., J Biol Chem., 247, 3767-3773 (1972).
16. Ono T., Bloch K., J Biol. Chem, 250, 1571-1579 (1975).
17. Brown M. S., Dana S. E., Goldstern J. L, J. Biol Chem, 249, 789-796 (1974).
18. Folch J, Lees M., Stanley G. H. S., J Biol Chem., 226, 497-509 (1957).
19. Bradford M. M. Anal. Biochem., 72, 248-254 (1976).
20. Amin D., Gustafson S., Perrone M. H., Biochem. Biophys. Res Commun, 157, 530-534 (1988).
21. Ma P. T. S, Gil G, Südhof T. C., Bilheimer D. W., Goldstern J. L., Brown M. S., Proc Natl Acad. Sci U.S.A., 83, 8370-8374 (1986).
22. Reihnér E., Rudling M., Ståhlberg D., Berglund L., Ewerth S., Björkhera I., Emarsson K., Angelin B., N. Engl. J. Med. 323, 224-228 (1990).
23. Koide K., Hayashi K., Honuchi I., Kajiyama G., Biochem. Biophys Acta, 1005, 65-71 (1989).
24. Chen J, Song W., Redinger R. N., Hepatology, 24, 424-434 (1996).
25. Tomimoto S, Tsujita M., Okazaki M., Usui S, Tada T., Fukutomi T., Ito S., Itoh M., Yokoyama S., Arterioscler. Thromb. Vasc Biol., 21, 391-400 (2001)
26. Hayashi K, Noshiro M., Kurushima H., Kuga Y., Nomura S., Ohkura Y., Ohtani H, Kurokawa J, Tanaka K., Yasunobu Y., Kambe M., Kajiyama G, Atherosclerosis, 111, 183-189 (1994).
27. Osborne T. F., Gil G., Goldstein J L., Brown M S., J Biol Chem., 263, 3380-3387 (1988).
28. Peffley D., Sinensky M., J. Biol Chem., 260, 9949-9952 (1985).
29. Nakanishi M., Goldstein J L., Brown M. S., J Biol. Chem., 263, 8929-8937 (1988).
30. Kawata S., Nagase T., Yamasaki E, Ishiguro H., Matsuzawa Y, Br. J. Cancer, 69, 1015-1020 (1994).
31. Nakamura Y, Sakakibara J., Izumi T., Shibata A., Ono T., J. Biol. Chem., 271, 8053-8056 (1996).
32. Hidaka Y., Hotta H., Nagata Y., Iwasawa Y., Horie M., Kamei T., J. Biol Chem., 266, 13171-13177 (1991).
33. Kovanen P. T, Bilheimer D. W., Goldstein J L, Jaramillo J. J., Brown M S., Proc Natl Acad. Sci. U.S.A. 78, 1194-1198 (1981).
34. Woollen L. A., Osono Y., Herz J., Dietschy J. M., Proc. Natl Acad. Sci. U.S.A, 92, 12500-12504 (1995).
35. Groot P H. E., Pearce N. J., Suckling K E, Eisenberg S., Biochem Biophys Acta. 1123, 76-84 (1992).
36. Oms P., Assie N., Bruniquel F., Degryse A., Haverbeke G, Delhon A., Pharmacol Toxicol., 77, 391-396 (1995).
37. Woollett L. A., Kearney D. M., Spady D. K, J Lipid Res, 38, 2289-2302 (1997)
38. Dietschy J. M, Turley S. D., Spady D. K., J Lipid Res., 34, 1637-1659 (1993).
39. Oram J. F., Yokoyama S., J. Lipid Res, 37, 2473-2491 (1996).