In vivo study of biodegradable alginate antibiotic beads in rabbits

Journal of Orthopaedic Research

Volumn 22, Issue 3, 2004, Pages 592-599

  Ueng, Steve W N ^a   Yuan, Li Jen ^a   Lee, Ning ^a   Lin, Song Shu ^a   Chan, Err Cheng ^a,b   Weng, Jui Hsun ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Alginate; Biodegradable antibiotic beads; In vivo study; Rabbit; Vancomycin

Indexed keywords

ALGINIC ACID; ANTIBIOTIC AGENT; CALCIUM CHLORIDE; CREATININE; KETAMINE; NITROGEN; POLYLYSINE; UREA; VANCOMYCIN; XYLAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; BIODEGRADABILITY; BIODEGRADABLE IMPLANT; BONE INFECTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG IMPLANTATION; DRUG RELEASE; FEMUR; FREEZE DRYING; HISTOPATHOLOGY; HOST; IN VIVO STUDY; MALE; MEASUREMENT; MINIMUM INHIBITORY CONCENTRATION; MYOSITIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; SAMPLING; STAPHYLOCOCCUS AUREUS; UREA NITROGEN BLOOD LEVEL;

ALGINATES; ANIMALS; ANTI-BACTERIAL AGENTS; BONE DISEASES; DRUG DELIVERY SYSTEMS; DRUG IMPLANTS; MALE; MUSCULAR DISEASES; POLYLYSINE; RABBITS; VANCOMYCIN;

EID: 1842864936     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.orthres.2003.09.001     Document Type: Article

References (48)

1. Aydelotte M.B. Thonar E.J.M. Mollenhauer J. et al. Culture of chondrocytes in alginate gel: variations in conditions of gelation influence the structure of the alginate gel and the arrangement and morphology of proliferating chondrocytes In Vitro Cell Dev. Biol. Anim. 34 1998 123-130
2. Baltimore R.S. Cross A.S. Dobek A.S. The inhibitory effect of sodium alginate on antibiotic activity against mucoid and non-mucoid strains of Pseudomonas aeruginosa J. Antimicrob. Chemother. 20 1987 815-823
3. Barrett S.E. Varley S.J. The effects of calcium alginate on wound healing Ann. R. Coll. Surg. Engl. 69 1987 153-155
4. Binette F. McQuaid D.P. Haudenschild D.R. et al. Expression of a stable articular cartilage phenotype without evidence of hypertrophy by adult human articular chondrocytes in vitro J. Orthop. Res. 16 1998 207-216
5. Buchholz H.W. Engelbrecht H. Uber die depotwirkung einiger antibiotica bei vermischung mit dem kunstharz palacos Chirurg 11 1970 511-515
6. Calhoun J.H. Mader J.T. Treatment of osteomyelitis with a biodegradable antibiotic implant Clin. Orthop. 341 1997 207-214
7. Cappai A. Petruzzo P. Ruiu G. et al. Evaluation of new small barium alginate microcapsules Int. J. Artif. Organs 18 1995 96-102
8. Christopher M.H. Vender J.R. Black P. Chemotherapy in experimental brain tumor part I: In vitro colorimetric MTT assay J. Neurooncol. 36 1998 1-6
9. Chun K.H. Kwon I.C. Kim Y.H. et al. Preparation of sodium alginate microspheres containing hydrophilic B-lactam antibiotics Arch. Pharm. Res. 19 1996 106-111
10. Couch L. Cierny G. Mader J.T. Inpatient and outpatient use of the Hickman catheter for adults with osteomyelitis Clin. Orthop. 219 1987 226-235
11. Dacquet V. Varlet A. Tandogan R.N. et al. Antibiotic-impregnated plaster of Paris beads Clin. Orthop. 282 1992 241-249
12. Downs E.C. Robertson N.E. Riss T.L. et al. Calcium alginate beads as a slow-release system for delivering angiogenic molecules in vivo and in vitro J. Cell Physiol. 152 1992 422-429
13. Esquisabel A. Hernandez R.M. Igartua M. et al. Production of BCG alginate-PLL microcapsules by emulsification/internal gelation J. Microencapsul. 14 1997 627-638
14. Gordon C.A. Hodges N.A. Marriott C. Antibiotic interaction and diffusion through alginate and exopolysaccharide of cystic fibrosis-derived Pseudomonas aeruginosa J. Antimicrob. Chemother. 22 1988 667-674
15. Grant G.T. Morris E.R. Rees D.A. et al. Biological interactions between polysaccharides and divalent cations: the egg-box model FEBS Lett. 32 1973 195-198
16. Greforiadis G. Liposome technology: targeted drug delivery and biological interaction vol. III 1984 1-282 CRC Press Inc Boca Raton, FL
17. Gustilo R.B. Mendoza R.M. Williams D.N. Problems in the management of type III open fracture J. Trauma. 24 1984 742-746
18. Guyton A.C. Hall J.E. Functional organization of the human body and control of the internal environment Guyton A.C. Textbook of medical physiology, 9th ed. 1996 3-9 WB Saunders Company Philadelphia
19. Heald K.A. Jay T.R. Downing R. Assessment of the reproducibility of alginate encapsulation of pancreatic islets using the MTT colorimetric assay Cell Transplant. 3 1994 333-337
20. Henry S.L. Seligson D. Mangino P. et al. Antibiotic-impregnated beads. Part I: Bead implantation versus systemic therapy Orthop. Rev. 20 1991 242-247
21. Jarvis A.P.J. Grdina T.A. Production of biologicals from microencapsulated living cells Biotechniques 1 1983 23-27
22. Joly A. Deshardins J.F. Fremond B. et al. Survival proliferation and functions of porcine hepatocytes encapsulated in coated alginate beads: a step toward a reliable bioartificial liver Transplant 63 1997 795-803
23. Kapelle H, Ridder M. Analysis of Vancomycin in Serum. Chrompack Application Note 400-HPLC Application Book. Middulburg, Netherlands Chrompack Inter BV Publication, 1996. p. 430
24. Kataoka K. Kwon G.S. Yokotama M. et al. Block copolymer micelles as vehicles for drug delivery J. Control Rel. 24 1993 119-132
25. Kelley S.S. Blackwood A.D. Caterson B. et al. Retention of the in vivo-formed pericellular matrix affects proteoglycan synthesis in vitro Trans. Orthop. Res. Soc. 21 1996 768
26. Khalfi F. Deni T. Gressier B. et al. Compatibility and stability of vancomycin hydrochloride with PVC infusion material in various conditions using stability-indicating high-performance liquid chromatographic assay Int. J. Pharmaceutics 139 1996 243-247
27. Kirkpatrick D.K. Trachtenberg L.S. Mangino P.D. et al. In vitro characteristics of tobramycin-polymethylmethacrylate beads: compressive strength and leaching Orthopedics 8 1985 1130-1133
28. Kitchell J. Wise D. Poly(lactic/glycolic acid) biodegradable drug-polymer matrix systems Methods Enzymol. 112 1985 436-448
29. Kobayshi H. Shirake K. Ikada Y. Toxicity test of biodegradable polymer by implantation in rabbit cornea J. Biomed. Mater. Res. 26 1992 1463-1476
30. Lee K.H. Lee P.M. Siaw Y.S. Immobilization of aminoacylase by encapsulation in poly-l-lysin-stabilized calcium alginate beads J. Chem. Tech. Biotechnol. 57 1993 27-32
31. Lin S.S. Ueng S.W.N. Liu S.J. et al. Development of a biodegradable antibiotic delivery system Clin. Orthop. 362 1999 240-250
32. Mader J.T. Calhoun J. Cobos J. In vitro evolution of antibiotic diffusion from antibiotic-impregnated biodegradable beads and polymethylmethacrylate beads Antimicrobi. Agents Chemother. 41 1997 415-418
33. Majid S.A. Lindberg L.T. Gunterberg B. et al. Gentamicin-PMMA beads in the treatment of chronic osteomyelitis Acta Orthop. Scand. 56 1985 265-268
34. May J.W. Jupiter J.B. Weiland A.J. et al. Clinical classification of post-traumatic tibial osteomyelitis J. Bone Joint Surg. [Am] A 71 1989 1422-1428
35. McKee M.D. Wild L.M. Schemitsch E.H. Waddell J.P. The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial J. Orthop. Trauma. 16 9 2002 622-627
36. Paham G.J. Mangino P. Seligson D. et al. Antibiotic-impregnated beads. Part II: Factors in antibiotics Orthop. Rev. 20 1991 331-337
37. Patzakis M.J. Kai M. Wilkin J. et al. Septopal beads and autogenous bone grafting for bone defects in patients with chronic osteomyelitis Clin. Orthop. 295 1993 112-118
38. Rembaum A. Tokes Z.A. Microspheres: medical and biological applications 1988 CRC Press Inc Boca Raton, FL
39. Setterstrom J.A. Tice T.R. Myers W.E. Development of encapsulate antibiotics for topical administration to wounds Kim S.W. Recent advances in drug delivery systems 1984 185-198 Plenum New York
40. Suzuki Y. Nishimura Y. Tanihara M. et al. Evaluation of a novel alginate gel dressing: cytotoxicity to fibroblasts in vitro and foreign-body reaction in pig skin in vivo J. Biomed. Mater. Res. 39 1998 317-322
41. Thu B. Bruheim P. Espevik T. et al. Alginate polycation microcapsules Biomaterials 17 1996 1031-1040
42. Ueng S.W.N. Wei F.C. Lee S.S. Shih C.H. Management of large infected tibial defect with antibiotic beads local therapy and staged fibular osteoseptocutaneous free transfer J. Trauma. 43 1997 268-274
43. Ueng S.W.N. Wei F.C. Shih C.H. Management of femoral diaphyseal infected nonunion with antibiotic beads local therapy, external skeletal fixation and stage bone grafting J. Trauma. 46 1999 97-103
44. Ueng S.W.N. Lee S.S. Lin S.S. et al. Biodegradable alginate antibiotic beads Clin. Orthop. 380 2000 250-259
45. Ueng S.W.N. Yuan L.J. Lee N. et al. In vivo study of hot compressing molded 50:50 poly (dl-lactide-co-glycolide) antibiotic beads in rabbits J. Orthop. Res. 20 2002 654-661
46. Vandenbossche G.M.R. Bracke M.E. Cuvelier C.A. et al. Host reaction against empty alginate-polylysine microcapsules. Influence of preparation procedure J. Pharm. Pharmacol. 45 1993 115-120
47. Wiegand P. Kroncke K.D. Kolb-Bachofen V. Macrophage-generated nitric oxide as cytotoxic factor in destruction of alginate-encapsulated islets Transplant 56 1993 1206-1212
48. Zhang X. Wyss U.P. Pichora D. et al. Biodegradable controlled antibiotic release devices for osteomyelitis: optimization of release properties J. Pharm. Pharmacol. 46 1994 718-724