Pyrido[3,2-b]indol-4-yl-amines - Synthesis and investigation of activity against malaria;Pyrido[3,2-b]indol-4-yl-amine - Synthese und prüfung auf wirksamkeit gegen malaria

Pharmazie

Volumn 59, Issue 4, 2004, Pages 243-250

  Gorlitzer K ^a   Kramer, C ^a   Meyer, H ^a   Walter, R D ^b   Jomaa, H ^b   Wiesner, J ^b  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 HYDROXY 3,5 BIS(PYRROLIDINOMETHYL)PHENYLAMINO] 5H PYRIDO[3,2 B]INDOL 3 CARBONIC ACID ETHYL ESTER; 4 CHLOROPYRIDINE DERIVATIVE; AMODIAQUINE DERIVATIVE; ANTIMALARIAL AGENT; CHLOROQUINE; INDOLE DERIVATIVE; MANNICH BASE; NOVALDIAME; PHENOL DERIVATIVE; PYRIDINE DERIVATIVE; PYRIDO[3,2 B]INDOL 4 YLAMINE DERIVATIVE; PYRIDO[3,2 B]INDOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DIFFERENTIAL PULSE VOLTAMMETRY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MALARIA; MOLECULAR STABILITY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM VINCKEI;

ADMINISTRATION, ORAL; AMINES; ANIMALS; ANTIMALARIALS; ELECTROCHEMISTRY; INDICATORS AND REAGENTS; INDOLES; INJECTIONS, INTRAPERITONEAL; MALARIA; MANNICH BASES; MICE; MICE, INBRED BALB C; PLASMODIUM FALCIPARUM; PYRIDINES;

EID: 1842862809     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ancelin ML, Calas M, Bompart J, Cordina G, Martin D, Ben Bari M, Jei T, Druilhe P, Vial HJ (1998) Antimalarial activity of 77 phospholipid polar head analogs: close correlation between inhibition of phospholipid metabolism and in vitro Plasmodium falciparum growth. Blood 91: 1426-1437.
2. Andersag H (1948) Antimalariamittel aus der Gruppe halogensubstituierter Chinolinverbindungen. Chem Ber 81: 499-507.
3. Burckhalter JH, Tendick FH, Jones EM, Jones PA, Holcomb WF, Rawlins AL (1948) Aminoalkylphenols as Antimalarials. II (Heterocyclic-amino)-á -amino-o-cresols. The Synthesis of Camoquin. J Am Chem Soc 70: 1363-1373.
4. Boyarintseva ON, Kurilo GN, Anisimova OS, Grinev AN (1977) Reaction of 3-aminoindole-2-carboxylic acids with an acetylenedicarboxylate ester. Khim Geterotsikl Soedin: 82-84; CA 86: 189761p.
5. Boyarintseva ON, Kurilo GN, Anisimova OS, Grinev AN (1977) Reaction of 3-aminoindole-2-carboxylic acids with an acetylenedicarboxylate ester. Khim Geterotsikl Soedin: 82-84; CA 86: 189761p.
6. Desjardins RE, Canfield CJ, Haynes JD, Chulay JD (1979) Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother 16: 710-718.
7. Görlitzer K, Stockmann R, Walter RD (1994) Gegen Malaria wirksame 10H-Indolo[3,2-b]chinoline-11-yl-amine, 1. Mitt.: Phenol-Mannich-Basen vom Amodiaquin- und Cycloquin-Typ. Pharmazie 49: 231-235.
8. Görlitzer K, Stockmann R, Walter RD (1995) Gegen Malaria wirksame 10H-Indolo[3,2-b]chinoline-11-yl-amine, 2. Mitt.: Chloroquin-Analoge. Pharmazie 50: 105-111.
9. Görlitzer K, Herbig S, Walter RD (1997) Indeno[1,2-b] pyridin-4-yl-amine. Pharmazie 52: 504-510.
10. Görlitzer K, Herbig S, Walter RD (1997) Indeno[1,2-d]pyrimidin-4-yl-amine. Pharmazie 52: 670-672.
11. Görlitzer K, Kramer C (2000) Reaktionen von 4,5-Dihydro-4-oxo-1H-pyrido[3,2-b]indol-2-carbonsäurestern. Pharmazie 55: 273-281.
12. Hawley SRR, Bray PG, O'Neill PM, Naisbitt DJ, Park BK, Ward S (1996) Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component. Antimicrob Agents Chemother 40: 2345-2349.
13. Ludvik J, Volke J, Pragst F (1986) Investigation of two radical intermediates in the anodic oxidation of 1,4-dihydropyridines by electrochemiluminescence. J Electroanal Chem 215: 179-190.
14. Ludvik J, Volke J, Klima J (1987) Electrochemical oxidation mechanisms of different type 1,4-Dihydropyridine derivatives in acetonitrile. Electrochim Acta 32: 1063-1071.
15. Minami S, Yamabe S, Sakurai H, Hirose T (1976) Pyridonecarboxylic acid derivatives. Japan. Kokai 76.136.698; CA 87: 5937s (1977).
16. Peters W. in Kreier JP (1980) Malaria, vol. 1, p. 160-161.
17. Rangisetti JB, Gupta CNVHB, Prasad AL, Srinivas P, Sridhar N, Parimoo P, Veeranjaneyulu A (2001) Synthesis of new arylaminoquinoxalines and their antimalarial activity in mice. J Pharm Pharmacol 53: 1409-1414.
18. Skala V, Volke J, Ohanka V, Kuthan J (1977) On dihydropyridines. XXXV. Electrochemical oxidation of 3,5-difunctional 1,4-dihydropyridine derivatives. Collect Czech Chem Commun 42: 292-305.
19. Stout DM, Matier WL, Barcelon-Yang C, Reynolds RD, Brown BS (1983) Synthesis and Antiarrhythmic and Parasympatholytic Properties of Substituted Phenols. 1. Heteroarylamine Derivatives. J Med Chem 26: 808-813.
20. Trager W, Jensen JB (1976) Human malaria parasites in continuous culture. Science 193: 673-675.
21. Unangst PC (1983) Pyrido[1′,2′:1,2]pyrimido[5,4-d]indoles. A new heterocyclic ring system. J Heterocycl Chem 20: 495-499.