Anti-tumor effect of merocyanine 540-mediated photochemotherapy combined with Edelfosine: Potential implications for the ex vivo purging of hematopoietic stem cell grafts from breast cancer patients

Journal of Photochemistry and Photobiology B: Biology

Volumn 68, Issue 2-3, 2002, Pages 101-108

  Anderson, Gregory S ^a   Miyagi, Kiyoko ^a   Sampson, Reynée W ^a   Sieber, Fritz ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Autologous stem cell transplantation; Breast cancer; Edelfosine; Merocyanine 540; Photodynamic therapy

Indexed keywords

ALKYLLYSOPHOSPHOLIPID; ANTINEOPLASTIC AGENT; CD34 ANTIGEN; EDELFOSINE; MEROCYANINE; ETHER PHOSPHOLIPID; LEUKOCYTE ANTIGEN; MEROCYANINE DYE; PYRIMIDINONE DERIVATIVE; RADIOSENSITIZING AGENT;

ALLOGRAFT; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW METASTASIS; BREAST CANCER; CANCER PATIENT; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG STRUCTURE; GRANULOCYTE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIGH RISK PATIENT; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; LEUKEMIA CELL; LIVER METASTASIS; LYMPHOMA CELL; MACROPHAGE; NONHUMAN; PHOTOCHEMOTHERAPY; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; SOLID TUMOR; STEM CELL; TUMOR RECURRENCE; ANIMAL; BREAST TUMOR; CELL CULTURE; CRYOPRESERVATION; DRUG EFFECT; DRUG SCREENING; FEMALE; MOUSE; PATHOLOGY;

MURINAE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD34; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CRYOPRESERVATION; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; MICE; PHOSPHOLIPID ETHERS; PHOTOCHEMOTHERAPY; PYRIMIDINONES; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 1842854337     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(02)00377-9     Document Type: Article

References (55)

1. L. Vahdat, K. Antman, High-dose chemotherapy with autologous stem cell support for breast cancer, Curr. Opin. Hematol. 4 (1997) 381-389.
2. G.N. Hortobagyi, A.U. Buzdar, R.L. Theriault, V. Valero, D. Frye, D.J. Booser, F.A. Holmes, S. Giralt, I. Khouri, B. Anderson, J.L. Gajewski, G. Rodon, T.L. Smith, S.E. Singletary, F.C. Ames, N. Sneige, E.A. Strom, M.D. McNeese, A.B. Deisseroth, R.E. Champlin, Randomized trial of high-dose chemotherapy and blood cell autografts for high-risk primary breast carcinoma, J. Natl. Cancer Inst. 92 (2000) 225-233.
3. Y. Nieto, R.E. Champlin, J.R. Wingard, J.F. Vredenburgh, A.D. Elias, P. Richardson, J. Glaspy, R.B. Jones, P.J. Stiff, S.I. Bearman, P.J. Cagnoni, P.A. McSweeney, C.F. LeMaistre, A.L. Pecora, E.F. Shpall, Status of high-dose chemotherapy for breast cancer: a review, Biol. Blood Marrow Transpl. 6 (2000) 476-495.
4. S.S. Joshi, A. Kessinger, S.L. Mann, M. Stevenson, D.D. Weisenburger, W.P. Vaughan, J.O. Armitage, J.G. Sharp, Detection of malignant cells in histologically normal bone marrow using culture techniques, Bone Marrow Transpl. 1 (1987) 303-310.
5. W.H. Krüger, M. Stockschläder, S. Hennings, M. Aschenbrenner, M. Gruber, K. Gutensohn, C. Löliger, F. Gieseking, W. Jonat, A.R. Zander, Detection of cancer cells in peripheral blood stem cells of women with breast cancer by RT-PCR and cell culture, Bone Marrow Transplant. 18 (1996) S18-S20.
6. W.A. Franklin, E.J. Shpall, P. Archer, C.S. Johnston, S. Garza-Williams, L. Hami, M.A. Bitter, R.C. Bast, R.B. Jones, Immunocytochemical detection of breast cancer cells in marrow and peripheral blood of patients undergoing high dose chemotherapy with autologous stem cell support, Breast Cancer Res. Treatment 41 (1996) 1-13.
7. B.E. Brockstein, A.A. Ross, T.J. Moss, D.G. Kahn, K. Hollingsworth, S.F. Williams, Tumor cell contamination of bone marrow harvest products: clinical consequences in a cohort of advanced-stage breast cancer patients undergoing high-dose chemotherapy, J. Hematother. 5 (1996) 617-624.
8. K.K. Fields, G.J. Elfenbein, W.L. Trudeau, J.B. Perkins, W.E. Janssen, L.C. Moscinski, Clinical significance of bone marrow metastases as detected using the polymerase chain reaction in patients with breast cancer undergoing high-dose chemotherapy and autologous bone marrow transplantation, J. Clin. Oncol. 14 (1996) 1868-1876.
9. P. Pedrazzoli, M. Battaglia, G.A. Da Prada, A. Lanza, A. Cuomo, F. Bertolini, L. Pavesi, G. Robustelli della Cuna, Role of tumor cells contaminating the graft in breast cancer recurrence after high-dose chemotherapy, Bone Marrow Transpl. 20 (1997) 167-169.
10. J.J. Vredenburgh, O. Silva, G. Broadwater, D. Berry, K. DeSombre, C. Tyer, W.P. Petros, W.P. Peters, R.C. Bast Jr., The significance of tumor contamination in the bone marrow from high-risk primary breast cancer patients treated with high-dose chemotherapy and hematopoietic support, Biol. Blood Marrow Transplant. 3 (1997) 91-97.
11. B.W. Cooper, T.J. Moss, A.A. Ross, J. Y-banez, H.M. Lazarus, Occult tumor contamination of hematopoietic stem-cell products does not affect clinical outcome of autologous transplantation in patients with metastatic breast cancer, J. Clin Oncol. 16 (1998) 3509-3517.
12. N.C. Gorin, Marrow purging for autologous bone marrow transplantation and its role in acute myelocytic leukemia, Leukemia 6 (1992) 96-101.
13. K.K. Matthay, J.G. Villablanca, R.C. Seeger, D.O. Stram, R.E. Harris, N.K. Ramsay, P. Swift, H. Shimada, C.T. Black, G.M. Brodeur, R.B. Gerbing, C.P. Reynolds, Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group, New Engl. J. Med. 341 (1999) 1165-1173.
14. C.B. Miller, P.A. Rowlings, M.-J. Zhang, R.J. Jones, S. Piantadosi, A. Keating, J.O. Armitage, S. Calderwood, R.E. Harris, J.P. Klein, H.M. Lazarus, C.A. Linker, K.A. Sobocinski, D. Weisdorf, M.M. Horowitz, The effect of graft purging with 4-hydroperoxycyclophosphamide in autologous bone marrow transplantation for acute myelogenous leukemia, Exp. Hematol. 29 (2001) 1336-1346.
15. K.C. O'Briant, E.J. Shpall, L.L. Houston, W.P. Peters, R.C. Bast Jr., Elimination of clonogenic breast cancer cells from human bone marrow. A comparison of immunotoxin treatment with chemoimmunoseparation using 4-hydroperoxycyclophosphamide, monoclonal antibodies, and magnetic microspheres, Cancer 68 (1991) 1272-1278.
16. J.J. Vredenburgh, W. Simpson, V.A. Memoli, E.D. Ball, Reactivity of anti-CD15 monoclonal antibody PM-81 with breast cancer and elimination of breast cancer cells from human bone marrow by PM-81 and immunomagnetic beads, Cancer Res. 51 (1991) 2451-2455.
17. H.F. Dietzfelbinger, D. Kuhn, M. Zafferani, A.R. Hanauske, J.W. Rastetter, W.E. Berdel, Removal of breast cancer cells from bone marrow by in vitro purging with ether lipids and cryopreservation, Cancer Res. 53 (1993) 3747-3751.
18. S.S. Ingram, T. Samulski, R. Dodge, L.R. Prosnitz, W.P. Peters, J. Vredenburgh, The effects of hyperthermia in bone marrow purging of breast cancer, Int. J. Hypertherm. 12 (1996) 21-29.
19. K.A. Margolin, C. Wright, S.J. Forman, Autologous bone marrow purging by in situ IL-2 activation of endogenous killer cells, Leukemia 11 (1997) 723-728.
20. K.F. Mangan, M.T. Mullaney, F. Sieber, Amifostine protects CD34+ purified stem cells in the merocyanine photolytic purging system, Blood 90 (1997) 374a.
21. B.I. Lundell, J.J. Vredenburgh, C. Tyer, K. DeSombre, A.K. Smith, Ex vivo expansion of bone marrow from breast cancer patients: reduction in tumor cell content through passive purging, Bone Marrow Transpl. 22 (1998) 153-159.
22. N. Brasseur, I. Menard, A. Forget, R. El Jastimi, R. Hamel, N.A. Molfino, J.E. van Lier, Eradication of multiple myeloma and breast cancer cells by TH9402-mediated photodynamic therapy: implication for clinical ex vivo purging of autologous stem cell transplants, Photochem. Photobiol. 72 (2000) 780-787.
23. F. Sieber, J.L. Spivak, A.M. Sutcliffe, Selective killing of leukemic cells by merocyanine 540-mediated photosensitization, Proc. Natl. Acad. Sci. USA 81 (1984) 7584-7587.
24. F. Sieber, M. Sieber-Blum, Dye-mediated photosensitization of murine neuroblastoma cells, Cancer Res. 46 (1986) 2072-2076.
25. F. Sieber, S. Rao, S.D. Rowley, M. Sieber-Blum, Dye-mediated photolysis of human neuroblastoma cells: implications for autologous bone marrow transplantation, Blood 68 (1986) 32-36.
26. J. Atzpodien, S.C. Gulati, B.D. Clarkson, Comparison of the cytotoxic effects of merocyanine-540 on leukemic cells and normal human bone marrow, Cancer Res. 46 (1986) 4892-4895.
27. F. Sieber, R.K. Stuart, S.D. Rowley, S.J. Sharkis, L.L. Sensenbrenner, Dye-mediated photolysis of normal and neoplastic hematopoietic cells, Leukemia Res. 11 (1987) 43-49.
28. A. Porcellini, N. Talevi, M.T. Marchetti -Rossi, M. Palazzi, A. Manna, G. Sparaventi, C. Delfini, M. Valentini, Limiting dilution analysis for the determination of leukemic cell frequencies after bone marrow decontamination with mafosfamide or merocyanine 540, Blood 70 (1987) 1543-1549.
29. F. Sieber, Photosensitizing agents for marrow purging in autologous bone marrow transplantation, in: N.C. Gorin, L. Douay (Eds.), Experimental Hematology Today, Springer-Verlag, New York, 1989, pp. 10- 15.
30. M. Mumcuoglu, L. Weiss, J. Spivak, S. Slavin, Differential killing of murine B-cell leukemia (BCL1) by photosensitization with merocyanine 540: implications for autologous bone marrow transplantation, Bone Marrow Transpl. 4 (1989) 143-146.
31. F. Sieber, Extracorporeal purging of bone marrow grafts by dye-sensitized photoirradiation, in: A.P. Gee (Ed.), Bone Marrow Processing and Purging: A Practical Guide, CRC Press, Boca Raton, FL, 1991, pp. 263-280.
32. T. Itoh, H.A. Messner, N. Jamal, M. Tweeddale, F. Sieber, Merocyanine 540-sensitized photoinactivation of high-grade non-Hodgkin's lymphoma cells: Potential application in autologous bone marrow transplantation, Bone Marrow Transpl. 12 (1993) 191-196.
33. K.F. Mangan, personal communication, 2001.
34. T. Yamazaki, F. Sieber, The alkyl-lysophospholipid, ET-18-OCH, synergistically enhances the Merocyanine 540-mediated photoinactivation of leukemia cells: Implications for the extracorporeal purging of autologous hematopoietic stem cells, Bone Marrow Transpl. 19 (1997) 113-119.
35. N.N. Iscove, F. Sieber, K.H. Winterhalter, Erythroid colony formation in cultures of mouse and human bone marrow: analysis of the requirement for erythropoietin by gel filtration and affinity chromatography on agarose-concanavalin-A, J. Cell. Physiol. 83 (1974) 309-320.
36. 3, J. Hematother. 7 (1998) 286.
37. R.C. Meagher, F. Sieber, J.L. Spivak, Susceptibility to Merocyanine 540-mediated photosensitization: a differentiation marker on murine hematopoietic progenitor cells, J. Cell. Physiol. 116 (1983) 118-124.
38. Y. Kubo, F. Sieber, Photochemical purging of autologous bone marrow grafts: assessment of damage to stem cells and the microenvironment in long-term marrow cultures, Bone Marrow Transpl. 20 (1997) 27-31.
39. S.D. Rowley, M. Zuehlsdorf, H.G. Braine, O.M. Colvin, J. Davis, R.C. Jones, R. Saral, L.L. Sensenbrenner, A. Yeager, G.W. Santos, CFU-GM content of bone marrow grafts correlates with time to hematologic reconstitution following autologous bone marrow transplantation with 4-hydroperoxycyclophosphamide-purged bone marrow, Blood 70 (1987) 272-275.
40. S.D. Rowley, S. Piantadosi, D.C. Marcellus, R.J. Jones, N.E. Davidson, J.M. Davis, J. Kennedy, J.M. Wiley, JR. Wingard, A.M. Yeager, Analysis of factors predicting speed of hematologic recovery after transplantation with 4-hydroperoxycyclophosphamide-purged autologous bone marrow grafts, Bone Marrow Transpl. 7 (1991) 183-191.
41. I. Tsujino, F. Sieber, Genetic variability in the response of normal murine hematopoietic progenitor cells to extracorporeal photochemotherapy, Photochem. Photobiol. 72 (2000) 810-814.
42. J.E. Valinsky, T.G. Easton, E. Reich, Merocyanine 540 as a fluorescent probe of membranes: selective staining of leukemic and immature hemopoietic cells, Cell 13 (1978) 487-500.
43. W.R. Vogler, W.E. Berdel, A.C. Olson, E.F. Winton, L.T. Heffner, D.S. Gordon, Autologous bone marrow transplantation in acute leukemia with marrow purged with alkyl-lysophospholipid, Blood 80 (1992) 1423-1429.
44. W.R. Vogler, W.E. Berdel, R.B. Geller, J.A. Brochstein, R.A. Beveridge, W.S. Dalton, K.B. Miller, H.M. Lazarus, A phase II trial of autologous bone marrow transplantation (ABMT) in acute leukemia with edelfosine purged bone marrow, Adv. Exp. Med. Biol. 416 (1996) 389-396.
45. M.P. Koenigsmann, M. Notter, W.U. Knauf, C.A. Papadimitriou, D. Oberberg, B. Reufi, C. Mucke, E. Thiel, W.E. Berdel, Chemopurging of peripheral blood-derived progenitor cells by alkyl-lysophospholipid and its effect on haematopoietic rescue after high-dose therapy, Bone Marrow Transpl. 18 (1996) 549-557.
46. D.K. Gaffney, S.L. Schober, F. Sieber, Merocyanine 540-sensitized photoinactivation of leukemia cells: Role of oxygen and effects on plasma membrane integrity and mitochondrial respiration, Exp. Hematol. 18 (1990) 23-26.
47. D.K. Gaffney, F. Sieber, Merocyanine 540-sensitized photoinactivation of soluble and membrane-bound enzymes in L1210 leukemia cells, Cancer Res. 50 (1990) 7765-7769.
48. O.M. Smith, D.L. Traul, F. Sieber, Photodamaging effects of merocyanine 540 on neutrophils and HL-60 cells, Exp. Hematol. 20 (1992) 1278-1284.
49. B. Kalyanaraman, J.B. Feix, F. Sieber, J.P. Thomas, A.W. Girotti, Photodynamic action of merocyanine 540 on artificial and natural cell membranes: involvement of singlet molecular oxygen, Proc. Natl. Acad. Sci. USA 84 (1987) 2999-3003.
50. J.M. O'Brien, R.J. Singh, J.B. Feix, B. Kalyanaraman, F. Sieber, Action spectra of the antileukemic and antiviral activities of merocyanine 540, Photochem. Photobiol. 54 (1991) 851-854.
51. D.L. Traul, O.M. Smith, F. Sieber, Effects of merocyanine 540-sensitized photoirradiation on cation homeostasis in L1210 leukemia and A549 lung cracinoma cells, Exp. Hematol. 20 (1992) 730.
52. O.M. Smith, D.K. Gaffney, M.S. Anderson, L. McOlash, S.L. Schober, F. Sieber, Plasma membrane properties regulating the sensitivity of leukemia, lymphoma, and solid tumor cells to merocyanine 540-sensitized photoirradiation, Exp. Hematol. 19 (1991) 785-788.
53. T. Yamazaki, F. Sieber, Role of cytoprotective mechanisms in the photochemical purging of autologous bone marrow graft, Exp. Hematol. 25 (1997) 629-637.
54. D. Berkovic, Cytotoxic etherphospholipid analogues, Gen. Pharmacol. 31 (1998) 511-517.
55. B.A. Wagner, G.R. Buettner, C.P. Burns, Increased generation of lipid-derived and ascorbate free radicals by L1210 cells exposed to the ether lipid edelfosine, Cancer Res. 53 (1993) 711-713.