Clinical Significance of Bone Marrow Metastases as Detected Using the Polymerase Chain Reaction in Patients with Breast Cancer Undergoing High-Dose Chemotherapy and Autologous Bone Marrow Transplantation

Journal of Clinical Oncology

Volumn 14, Issue 6, 1996, Pages 1868-1876

  Fields, Karen K ^a   Elfenbein, Gerald J ^a   Trudeau, Walter L ^a   Perkins, Janelle B ^a   Janssen, William E ^a   Moscinski, Lynn C ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CYTOKERATIN; CYTOKERATIN 19; ETOPOSIDE; IFOSFAMIDE;

ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW METASTASIS; BREAST CANCER; CANCER STAGING; CLINICAL TRIAL; DIAGNOSTIC ACCURACY; DRUG MEGADOSE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW NEOPLASMS; BONE MARROW TRANSPLANTATION; BREAST NEOPLASMS; CARBOPLATIN; COMBINED MODALITY THERAPY; DISEASE-FREE SURVIVAL; ETOPOSIDE; FEMALE; HUMANS; IFOSFAMIDE; IMMUNOHISTOCHEMISTRY; KERATINS; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROGNOSIS; RECURRENCE; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 0029994110     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1996.14.6.1868     Document Type: Article

References (25)

1. Coombs R: The staging of human breast cancer: Physical staging techniques, in Coombs R, Powles T, Ford H, et al (eds): Breast Cancer Management: The Experience of the Combined Breast Clinic, St Georges Hospital and Royal Marsden Hospital. San Diego, CA, Academic, 1981, pp 77-95
2. Osborne MP, Wong GY, Asina S, et al: Sensitivity of immunocytochemical detection of breast cancer cells in human bone marrow. Cancer Res 51:2706-2709, 1991
3. Joshi SS, Novak DJ, Messbarger L, et al: Levels of detection of tumor cells in human bone marrow with or without prior culture. Bone Marrow Transplant 6:179-183, 1990
4. Redding WH, Coombes RC, Monaghan P, et al. Detection of micrometastases in patients with primary breast cancer. Lancet 2:1271-1274, 1983
5. Harbeck N, Untch M, Pache L, et al: Tumour cell detection in the bone marrow of breast cancer patients at primary therapy: Results of a 3-year median follow-up. Br J Cancer 69:566-571, 1994
6. Dearnaley D, Ormerod M, Sloan J: Micrometastases in breast cancer: Long-term follow-up of the first patients cohort. Eur J Cancer 27:236-239, 1991
7. Mansi JL, Easton D, Berger U, et al: Bone marrow micrometastases in primary breast cancer: Prognostic significance after 6 years' follow-up. Eur J Cancer 27:1552-1555, 1991
8. Cote RJ, Rosen PP, Lesser ML, et al: Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases. J Clin Oncol 9:1749-1756, 1991
9. Diel IJ, Kaufmann M, Goerner R, et al: Detection of tumor cells in bone marrow of patients with primary breast cancer: A prognostic factor for distant metastasis. J Clin Oncol 10:1534-1539, 1992
10. Dobrovic A, Trainor KJ, Morley AA: Detection of the molecular abnormality in chronic myeloid leukemia by use of the polymerase chain reaction. Blood 72:2063-2065, 1988
11. Moscinski LC, Trudeau WL, Fields KK, et al: High sensitivity detection of minimal residual breast carcinoma using the polymerase chain reaction and primers for cytokeratin 19. Diagn Mol Pathol (in press)
12. Fields KK, Moscinski LC, Hebel DC, et al: Polymerase chain reaction (PCR) evaluation of bone marrow micrometastases in metastatic breast cancer. Breast Cancer Res Treat 27:144, 1993 (abstr)
13. Fields K, Moscinski L, Trudeau W, et al: The use of polymerase chain reaction (PCR) for amplification of cytokeratin 19 (K19) to detect bone marrow (BM) micrometastases in breast cancer (CA). Proc Am Soc Clin Oncol 13:115, 1994 (abstr)
14. Antman K, Corringham R, de Vries E, et al: Dose intensive therapy in breast cancer. Bone Marrow Transplant 10:67-73, 1992 (suppl)
15. Datta YH, Adams PT, Drobyski WR, et al: Sensitive detection of occult breast cancer by the reverse-transcriptase polymerase chain reaction. J Clin Oncol 12:475-482, 1994
16. Sharp JG, Kessinger A, Vaughan WP, et al: Detection and clinical significance of minimal tumor cell contamination of peripheral stem cell harvests. Int J Cell Cloning 10:92, 1992 (suppl 1, abstr)
17. Ross AA, Cooper BW, Lazarus HM, et al: Detection and viability of tumor cells in peripheral blood stem cell collections from breast cancer patients using immunocytochemical and clonogenic assay techniques. Blood 82:2605-2610, 1993
18. Fields KK, Elfenbein GJ, Lazarus HM, et al: Maximum tolerated doses of ifosfamide, carboplatin, and etoposide given over six days followed by autologous stem cell rescue: Toxicity profile. J Clin Oncol 13:323-332, 1995
19. Fields KK, Zorsky PE, Hiemenz JW, et al: Ifosfamide, carboplatin, and etoposide: A new regimen with a broad spectrum of activity. J Clin Oncol 12:544-552, 1994
20. Untch M, Hagen D, Fields K, et al: The use of CK 19 RT-PCR for the detection of tumor cells in the bone marrow of patients with primary breast cancer. Breast Cancer Treat Res 37:102, 1996 (suppl, abstr)
21. Kessinger A, Reed E, Vaughan W, et al: Clinical outcome of patients (pts) with breast cancer and gynecological epithelial tumors undergoing high-dose therapy and peripheral stem cell transplantation with or without minimally contaminated aphersis harvests. Proc Am Soc Clin Oncol 12:A97, 1993 (abstr)
22. Vrendenburgh J, Silva O, de Sombre K, et al: The significance of bone marrow micrometastases for patients (pts) with breast cancer and ≥ 10+ lymph nodes treated with high-dose chemotherapy and hematopoietic support. Proc Am Soc Clin Oncol 14:A317, 1995 (abstr)
23. Brenner MK, Rill DR, Moen RC, et al: Gene marking and autologous bone marrow transplantation. Ann NY Acad Sci 716:204-214, 1994
24. Fields KK, Trudeau W, Moscinski L, et al: PCR detection of breast cancer cells in patient matched blood and marrow specimens. J Hematother 4:215, 1995 (abstr)
25. Brugger W, Bross KJ, Glatt M, et al: Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors. Blood 83:636-640, 1994