Severe immune dysfunction after lethal neutron irradiation in a JCO nuclear facility accident victim

International Journal of Hematology

Volumn 76, Issue 2, 2002, Pages 157-164

  Nagayama, Hitomi ^a,b   Ooi, Jun ^a   Tomonari, Akira ^a   Iseki, Tohru ^a   Tojo, Arinobu ^a   Tani, Kenzaburo ^a   Takahashi, Tsuneo A ^a   Yamashita, Naohide ^a   Asano, Shigetaka ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autologous hematopoietic recovery; Immune dysfunction; Neutron irradiation; Umbilical cord blood transplantation

Indexed keywords

ALLOANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; URANIUM;

ARTICLE; CELL FRACTIONATION; CELL FUNCTION; CHIMERA; GAMMA RADIATION; HELPER CELL; HEMATOPOIETIC SYSTEM; HUMAN; IMMUNE SYSTEM; IMMUNOGLOBULIN PRODUCTION; IMMUNOPATHOLOGY; IN VITRO STUDY; INFECTION; IRRADIATION; JAPAN; LETHALITY; LEUKOCYTE; MITOGENESIS; NEUTRON; NUCLEAR ACCIDENT; RADIATION DOSE; RADIATION INJURY; RESPIRATORY DISTRESS SYNDROME; SKIN TRANSPLANTATION; T LYMPHOCYTE; ALLOTRANSPLANTATION; CASE REPORT; CORD BLOOD STEM CELL TRANSPLANTATION; ELECTRIC POWER PLANT; FAST NEUTRON RADIATION; FATALITY; HEMATOPOIESIS; HISTOCOMPATIBILITY; IMMUNOLOGY; PATHOLOGY; RADIATION ACCIDENT; RADIATION EXPOSURE;

ACCIDENTS, RADIATION; CORD BLOOD STEM CELL TRANSPLANTATION; FAST NEUTRONS; FATAL OUTCOME; HEMATOPOIESIS; HISTOCOMPATIBILITY; HUMANS; IMMUNE SYSTEM; JAPAN; POWER PLANTS; RADIATION INJURIES; SKIN TRANSPLANTATION; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS; URANIUM;

EID: 1842846601     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02982579     Document Type: Article

References (27)

1. Baranov A, Gale RP, Guskova A, et al. Bone marrow transplantation after the Chernobyl nuclear accident. N Engl J Med. 1989;321:205-212.
2. Diagnosis and Treatment of Radiation Injuries. Safety reports series no. 2. Vienna: International Atomic Energy Agency, 1998.
3. Gluckman E, Broxmeyer HE, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical cord blood from a HLA identical sibling. N Engl J Med. 1989;321:1174-1178.
4. Rubinstein P, Dobrila L, Rosenfield RE, et al. Processing and cryopreservation of placental/umbilical cord blood for unrelated marrow reconstitution. Proc Natl Acad Sci U S A. 1995;92:10119-10122.
5. Kurtzberg J, Laughlin M, Graham ML, et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. N Engl J Med. 1996;335:157-166.
6. Wagner JE, Rosenthal J, Sweetman R, et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood. 1996;88:795-802.
7. Cairo MS, Wagner JE. Placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation. Blood. 1997;90:4665-4678.
8. Gluckman E, Rocha V, Boyer-Chammard A, et al. Outcome of cord-blood transplantation from related and unrelated donors. N Engl J Med. 1997;337:373-381.
9. Rubinstein P, Carrier C, Scaradavou A, et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med. 1998;339:1565-1577.
10. Rocha V, Wagner JE, Sobocinski KA, et al. Graft-versus-host diseases in children who have received a cord blood or bone marrow transplantation from an HLA-identical sibling. N Engl J Med. 2000;342:1846-1854.
11. Barker JN, Davies SM, DeFor T, et al. Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor marrow: results of a matched-pair analysis. Blood. 2001;97:2957-2961.
12. Rocha V, Cornish J, Sievers EL, et al. Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood. 2001;97:2962-2971.
13. Laporte JP, Gorin NC, Rubinstein P, et al. Cord-blood transplantation from an unrelated donor in an adult with chronic myelogenous leukemia. N Engl J Med. 1996;335:167-170.
14. Laughlin MJ, Barker J, Bambach B, et al. Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. N Engl J Med. 2001;344:1815-1822.
15. Sanz GF, Saavedra S, Jimenez C, et al. Unrelated donor cord blood transplantation in adults with chronic myelogenous leukemia: results in nine patients from a single institution. Bone Marrow Transplant. 2001;27:693-701.
16. Nagayama H, Nakayama K, Yasuo K, et al. Immunological reconstitution after cord blood transplantation for an adult patient. Bone Marrow Transplant. 1999;24:211-213.
17. Machida U, Tojo A, Ooi J, et al. Refractory facial cellulitis following cosmetic rhinoplasty after cord-blood stem cell transplantation. Int J Hematol. 2000;72:98-100.
18. Report on the Preliminary Fact Finding Mission following the Accident at the Nuclear Fuel Processing Facility in Tokaimura, Japan. Vienna: International Atomic Energy Agency, 1999.
19. Kawachi K. Initial response of NIRS. Proceedings of International Symposium on the Criticality Accident in Tokaimura: Medical Aspects of Radiation Emergency. Chiba, Japan: National Institute of Radiological Science, 2001:24-34.
20. Akashi M. Dose estimation of victims severely exposed based on initial symptoms in the criticality accident in Tokaimura. Proceedings of International Symposium on the Criticality Accident in Tokaimura: Medical Aspects of Radiation Emergency. Chiba, Japan: National Institute of Radiological Science, 2001:72-80.
21. Nagayama H, Takahashi TA, Misawa K, et al. Case presentation of worker B. Proceedings of International Symposium on the Criticality Accident in Tokaimura: Medical Aspects of Radiation Emergency. Chiba, Japan: National Institute of Radiological Science, 2001:154-158.
22. Iseki T, Nagayama H, Ooi J, et al. Unrelated cord blood transplantation for a heavily irradiated patient. Proceedings of International Symposium on the Criticality Accident in Tokaimura: Medical Aspects of Radiation Emergency. Chiba, Japan: National Institute of Radiological Science, 2001:220-227.
23. Nagayama H, Misawa K, Tanaka H, et al. Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim. Bone Marrow Transplant. 2002;29:197-204.
24. Koike S, Ando K. Relative biological effectiveness of fast neutrons in murine tissues. Proceedings of International Symposium on the Criticality Accident in Tokaimura: Medical Aspects of Radiation Emergency. Chiba, Japan: National Institute of Radiological Science, 2001:66-71.
25. Sato K, Nagayama H, Takahashi TA. Aberrant CD3- and CD28-mediated signaling events in cord blood T cells are associated with dysfunctional regulation of Fas ligand-mediated cytotoxicity. J Immunol. 1999;162:4464-4471.
26. Hill RS, Peterson FB, Storb R, et al. Mixed hematologic chimerism after allogeneic marrow transplantation for severe aplastic anemia is associated with a higher risk of graft rejection and a lessened incidence of acute graft-versus-host disease. Blood. 1986;67:811-816.
27. Chiba S, Saito A, Ogawa S, et al. Allogeneic peripheral blood stem cell transplantation for a victim of the criticality accident in Tokaimura. Proceedings of International Symposium on the Criticality Accident in Tokaimura: Medical Aspects of Radiation Emergency. Chiba, Japan: National Institute of Radiological Science, 2001:212-218.