Aberrant CD3- and CD28-mediated signaling events in cord blood T cells are associated with dysfunctional regulation of Fas ligand-mediated cytotoxicity

Journal of Immunology

Volumn 162, Issue 8, 1999, Pages 4464-4471

  Sato, Katsuaki ^a   Nagayama, Hitomi ^a   Takahashi, Tsuneo A ^a  

^a THE UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD3 ANTIGEN; CD40 ANTIGEN; FAS LIGAND; INTERLEUKIN 2 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ARTICLE; BONE MARROW TRANSPLANTATION; CYTOTOXICITY; ENZYME ACTIVITY; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD;

EID: 0033561749     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Rubinstein P., R. E. Rosenfield, J. W. Adamson, and C. E. Stevens. 1993. Stored placental blood for unrelated bone marrow reconstitution. Blood 81:1679.
2. Rubinstein P., L. Dobrila, R. E. Rosenfield, J. W. Adamson, G. Migliaccio, A. R. Migliaccio, P. E. Taylor, and C. E. Stevens. 1995. Processing and cryo-preservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc. Natl. Acad. Sci. USA 92:10119.
3. Lee, S., S. Y. Chong, J. W. Lee, S. C. Kim, Y. H. Min, J. S. Hahn, and Y. W. Ko. 1997. Difference in the expression of Fas/Fas-ligand and lymphocyte subset reconstitution according to the occurrence of acute GVHD. Bone Marrow Transplant. 20:883.
4. Berthou C., S. Maida-Legros, A. Soulie, A. Wargnier, J. Guillet, C. Rabian, E. Gluckman, and M. Saaportes. 1995. Cord blood T lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes. Blood 85:1540.
5. Serizawa R., H. Kawasaki, T. Kawashima, T. Juji, C. Morimoto, and T. A. Takahashi. 1997. Low expression of interleukin-12 receptor β1 chain on cord blood lymphocytes. Blood 90:280.
6. Takahashi, N., K. Imanishi, H. Nishida, and T. Uchiyama. 1995. Evidence for immunologic immaturity of cord blood T cells. J. Immunol. 155:5213.
7. Saito, S., T. Morii, H. Umekage, K. Makita, K. Nishikawa, N. Narita, M. Ichijo, H. Morikawa, N. Ishii, M. Nakamura, and K. Suganuma. 1996. Expression of the interleukin-2 γ receptor chain on cord blood mononuclear cells. Blood 87:3344.
8. Brugnoni, D., P. Ario, D. Graf, M. Marconi, M. Lebowitz, A. Plebani, S. Giliani, F. Malacarne, R. Cattaneo, A. G. Ugazio, et al. 1994. Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the new born. Eur J. Immunol. 24:1919.
9. Durandy, A., G. D. S. Basile, B. Lisowska-Grospierre, J.-F. Gauchat, M. Forveille, R. A. Kroczek, J.-Y. Bonnefoy, and A. Fischer. 1995. Undetectable CD40 ligand expression on T cells and low B cell responses to CD40 binding agonists in human newborn. J. Immunol. 154:1560.
10. Lewis, D. B., C. Y. Charles, J. Meyer, B. K. English, S. J. Kahn, and C. B. Wilson. 1991. Cellular and molecular mechanisms for reduced interleukin-4 and interferon-γ production by neonatal T cells. J. Clin. Invest. 87:194.
11. Lee, S. M., Y. Suen, L. Chang, V. Bruner, J. Qian, J. Indes, E. Knoppel, C. V. D. Ven, and S. M. Cairo. 1996. Decreased interleukin-12 (IL-12) from activated cord versus adult peripheral blood mononuclear cells and upregulation of interferon-γ, natural killer, and lymphokine-activated killer activity by IL-12 in cord blood mononuclear cells. Blood 88:945.
12. Chalmers, I. M. H., G. Janossy, M. Contreras, and C. Navarrete. 1998. Intracellular cytokine profile of cord and adult blood lymphocytes. Blood 92:11.
13. Gonzalez-Garcia, A., L. R. Borlado, E. Leonardo, I. Merida, A.-C. Martinez, and A. C. Carrera. 1997. Lck is necessary and sufficient for Fas-ligand expression and apoptotic cell death in mature cycling T cells. J. Immunol. 158:4104.
14. Eischen, C.M., B. L. Williams, W. Zhang, L. E. Samelson, D. H. Lynch, R. T. Abraham, and P. J. Leibson. 1997. ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. J. Immunol. 159: 135.
15. Latinis, K. M., L. L. Carr, E. J. Peterson, L. A. Norian, and S. L. Eliason. 1997. Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events. J. Immunol. 158:4602.
16. lck and ZAP-70 tyrosine kinase activities. J. Immunol. 159:53.
17. Chan, E. D., B. W. Winston, M. B. Jarpe, M. W. Wynes, and D. W. H. Riches. 1997. Preferential activation of the p46 isoform of JNK/SAPK in mouse macrophages by TNF-α. Proc. Natl. Acad. Sci. USA 94:13169.
18. Reinhard C, B. Shamoon, V. Shyamala, and L. T. Williams. 1997. Tumor necrosis factor α-induced activation of c-jun N-terminal kinase is mediated by TRAF-2. EMBO J. 16:1080.
19. Song, H. Y., C. H. Regnier, C. J. Kirshning, D. V. Goeddel, and M. Rothe. 1997. Tumor necrosis factor (TNF)-mediated kinase cascade: bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc. Natl. Acad. Sci. USA 94:9792.
20. mapk, MKK3, and MKK4 by TNF-α in mouse bone marrow-derived macrophages. J. Immunol. 159:4491.
21. + T cells. Science 271:1272.
22. + T cells. Science 271:1276.
23. DeSilva, D.R., E. A. Jones, W. S. Feeser, E. J. Manos, and P. A. Scherle. 1997. The p38 mitogen-activated protein kinase pathway in activated and anergic Th1 cells. Cell. Immunol. 180:116.
24. Kayagaki, N., A. Kawasaki, T. Ebata, H. Ohmoto, S. Ikeda, S. Inoue, K. Yoshino, K: Okumura, and H. Yagita. 1995. Metalloproteinase-mediated release of human Fas ligand. J. Exp. Med. 182:1777.
25. Suda, T., H. Hashimoto, M. Tanaka, T. Ochi, and S. Nagata. 1997. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J. Exp. Med. 186:2045.
26. Sato, K., H. Kawasaki, H. Nagayama, R. Serizawa, J. Ikeda, C. Morimoto, K. Yasunaga, N. Yamaji, K. Tadokoro, T. Juji, and T. A. Takahashi. 1999. CC chemokine receptors, CCR-1 and CCR-3, are potentially involved in APC function of human peripheral blood monocyte-derived dendritic cells. Blood 93:34.
27. Risdon, G., J. Gaddy, F. B. Stehman, and H. E. Broxmeyer. 1994. Proliferative and cytotoxic responses of human cord blood T lymphocytes following allogeneic stimulation. Cell. Immunol. 154:14.
28. Wong, B., J. Arron, and Y. Choi. 1997. T cell receptor signals enhance susceptibility to Fas-mediated apoptosis. J. Exp. Med. 186:1939.
29. Porcu, P., J. Gaddy, and H. E. Broxmeyer. 1998. Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras. Proc. Natl. Acad. Sci. USA 95:4538.
30. Roncarolo, M. G., M. Bigler, S. Marino, E. Ciuti, P.-A. Tovo, and J. Wagner. 1996. Immune functions of cord blood cells before and after transplantation. J. Hematother. 5:157.
31. Sato, K., and A. Ochi. 1998. Superclustering of B cell receptor and Fc-γRIIBI activates Src homology 2-containing protein tyrosine phosphatase-1. J. Immunol. 161:2716.
32. Klingmuller, U., U. Lorenz, L. C. Cantley, B. G. Neel, and H. F. Lodish. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signaling. Cell 80:729.
33. Marengere, L. E. M., P. Waterhouse, G. S. Duncan, H. W. Mittrucker, G. S. Feng, and T. W. Mak. 1996. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272:1170.
34. Binstadt B. A., K. M. Brumbaugh, C. J. Dick, A. M. Scharenberg, B. L. Williams, M. Colonna, L. L. Lanier, J. P. Kinet, R. T. Abraham, and P. J. Leibson. 1996. Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation. Immunity 5:629.
35. Chu, Y., P. A. Solski, R. Khosravi, C. J. Der, and K. Kelly. 1996. The mitogen-activated protein kinase phosphatase PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmarker mutation. J. Biol. Chem. 271:16357.