Adhesive backing foil interactions affecting the elasticity, adhesion strength of laminates, and how to interpret these properties of branded transdermal patches

Drug Development and Industrial Pharmacy

Volumn 28, Issue 10, 2002, Pages 1251-1259

  Fauth, Christiane ^a   Wiedersberg, S ^b   Neubert, R H H ^c   Dittgen, M ^a  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Backing foil; Peel test; Pressure sensitive adhesive; Skin irritation; Tensile strength; Transdermal; Young's modulus

Indexed keywords

ADHESIVE AGENT; CUTANUM; ESTRADERM MX 50; ESTRADERM TTS 50; ESTRADIOL; ESTROGEN; FEM 7; OLEIC ACID; SILICONE; STAINLESS STEEL;

ADHESION; ARTICLE; DRUG DELIVERY SYSTEM; ELASTICITY; ESTROGEN THERAPY; FOIL; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; SKIN; SKIN IRRITATION; TEMPERATURE; TENSILE STRENGTH; THICKNESS; YOUNG MODULUS; DRUG EFFECT; INTRADERMAL DRUG ADMINISTRATION; PHARMACEUTICS;

ADHESIVES; ADMINISTRATION, CUTANEOUS; ESTRADIOL; HUMANS; SKIN; TECHNOLOGY, PHARMACEUTICAL;

EID: 1842845136     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120015358     Document Type: Article

References (17)

1. Munoz, A. OESCLIM: An advanced delivery system for HRT. Maturitas 1999, Nov., 39-47.
2. Spencer, T.S.; Smith, E.S.; Conjeevaram, S. Adhesive interactions between polymers and skin in transdermal delivery systems. Polym. Mater. Sci. Eng. 1990, 63, 337-339.
3. Dimas, D.A.; Dallas, P.P.; Rekkas, D.M.; Choulis, N.H. Effect of several factors on the mechanical properties of pressure-sensitive adhesives used in transdermal therapeutic systems. AAPS Pharm. Sci. Tech. 2000, 1.
4. Peterson, T.A.; Wick, S.M.; Ko, S. Design, development, manufacturing, and testing of transdermal drug delivery systems. In Transdermal and Topical Drug Delivery Systems; Ghosh, T.K., Pfister, W.R., Yum, S.I., Eds.; Interpharm Press: Illinois, 1997; 249-297.
5. Venkatraman, S.; Gale, R. Skin adhesives and skin adhesion. 1. Transdermal drug delivery systems. Biomaterials 1998, 19, 1119-1136.
6. Ko, C.U. Effect of skin penetration enhancers in transdermal drug delivery adhesives on skin adhesion and irritation. 23rd International Symposium on Controlled Release of Bioactive Materials, 1996; 281-282.
7. Lin, S.Y.; Lee, C.J.; Lin, Y.Y. Drug-polymer interaction affecting the mechanical properties, adhesion strength and release kinetics of piroxicam-loaded Eudragit E films plasticized with different plasticizers. J. Contr. Rel. 1995, 33, 375-381.
8. Diridollou, S.; Black, D.; Lagarde, J.M.; Gall, Y.; Berson, M.; Vabre, V.; Patat, F.; Vaillant, L. Sex-and site-dependent variations in the thickness and mechanical properties of human skin in vivo. Int. J. Cosmet. Sci. 2000, 22, 421-435.
9. Gomez-Panzani, E.; Williams, M.B.; Kuznicki, J.T.; Myers, W.R.; Zoller, S.A.; Bixler, C.A.; Winkler, L.C. Application and maintenance habits do make a difference in adhesion of Alora® transdermal systems. Maturitas 2000, 35, 57-64.
10. Gordon, S.F. Clinical experience with a seven-day estradiol transdermal system for estrogen replacement therapy. Am. J. Obstet. Gynecol. 1995, 173, 998-1004.
11. Müller, P.; Botta, L.; Ezzet, F. Bioavailability of estradiol from a new matrix and a conventional reservoir-type transdermal therapeutic system. Eur. J. Clin. Pharmacol. 1996, 51, 327-330.
12. Erianne, J.A.; Winter, L. Comparison of the local tolerability and adhesion of a new matrix system (Menorest) for estradiol delivery with an established transdermal membrane system (Estraderm TTS). Maturitas 1997, 26(2), 95-101.
13. von-Holst, T.; Salbach, B. Efficacy and tolerability of a new 7-day transdermal estradiol patch versus placebo in hysterectomized women with postmenopausal complaints. Maturitas 2000, 34, 143-153.
14. Guichard, J.P.; Sauron, R.; Jones, A.B. Comparison of the pharmacokinetics of 17 beta-estradiol after a single 4-day application of Oesclim 50, Oesclim 100, and Vivelle 0.05 (Menorest 50) transdermal delivery systems. J. Clin. Pharmacol. 1999, 39, 811-816.
15. PSTC-1, Peel Adhesion for Single Coated Tapes 180° Angle, Pressure Sensitive Tape Council, Illinois, 1996.
16. Satas, D., Peel. In Handbook of Pressure Sensitive Adhesive Technology, 2nd Ed.; Satas, D., Ed.; Van Nostrand Reinhold New York, 1989; 61-96.
17. Pharmacopeia JX, 1997.