Effect of several factors on the mechanical properties of pressure sensitive adhesives used in transdermal therapeutic systems

AAPS PharmSciTech

Volumn 1, Issue 2, 2000, Pages

  Dimas, Dimitrios A ^a   Dallas, Paraskevas P ^a   Rekkas, Dimitrios M ^a   Choulis, Nikolaos H ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Factorial design; Peel force; Penetration enchancers; Pressure sensitive adhensives; Transdermal drug delivery

Indexed keywords

ADHESIVE AGENT; DRUG; LAURIC ACID; OCTANOIC ACID; ACRYLIC ACID DERIVATIVE; LAURIC ACID DERIVATIVE; LAURIC ACID METHYL ESTER; OCTANOIC ACID DERIVATIVE; TISSUE ADHESIVE;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG FORMULATION; FACTORIAL ANALYSIS; MATERIAL COATING; MATHEMATICAL MODEL; PREDICTION; PRESSURE SENSE; PROCESS OPTIMIZATION; THICKNESS; TRANSDERMAL PATCH; ADHESION; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; EVALUATION; INTRADERMAL DRUG ADMINISTRATION; PHYSIOLOGY; PRESSURE; SKIN ABSORPTION;

ACRYLATES; ADHESIVENESS; ADMINISTRATION, CUTANEOUS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; LAURATES; MODELS, CHEMICAL; OCTANOIC ACIDS; PRESSURE; SKIN ABSORPTION; TISSUE ADHESIVES;

EID: 23144461096     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1007/bf02830531     Document Type: Article

References (13)

1. Mussolf MC. Pressure sensitive adhesives: Science and engineering. In: Chien YW, ed. Transdermal Controlled Systemic Medications. New York: Marcel Dekker Inc.; 1987:93-112.
2. Baker RW, Heller J. Materials selection for transdermal drug delivery systems. In: Hadgraft J, Guy RH, eds. Transdermal Drug Delivery: Developmental Issues and Research Initiatives. New York: Marcel Dekker Inc.; 1989:293-311.
3. Toddywalla R, Chien YW. Evaluation of silicone-based pressure sensitive adhesives for transdermal drug delivery. I. Effect of penetrant hydrophilicity. J Control Rel. 1990;14:29-41.
4. Hollingsbee DA, Timmins P. Topical adhesive systems. In: Gurny R, Junginger HE, eds. Bioadhesion - Possibilities and Future Trends. Stuttgard: Wissenschaftliche Verlagsgesellschaft; 1990:140-164.
5. Peterson TA, Wick SM, Ko C. Design, development, manufacturing and testing of transdermal drug delivery systems. In: Ghosh TK, Pfister WR, Yum SI, eds. Transdermal and Topical Drug Delivery Systems Illinois: Interpharm Press, 1997:249-297.
6. Ghosh TK, Banja AK. Methods of enhancement of transdermal drug delivery: Part IIA, Chemical permeation enhancers. Pharm Tech. April 1993;62-90.
7. Hille T. Technological aspects of permeation enhancers in transdermal systems. In: Walters KW, Hadgraft J, eds. Pharmaceutical Skin Permeation Enhancement. New York: Marcel Dekker Inc.; 335-343.
8. Bolton S. Pharmaceutical Statistics: Practical and Clinical Applications, 3rd ed..New York: Marcel Decker, Inc; 1997:326-625.
9. Armstrong NA, James KC. Understanding Experimental Design and Interpretation in Pharmaceutics. London: Ellis Horword; 1990:308-337.
10. Satas D. Handbook of Pressure Sensitive Adhesive Technology, 2nd ed. New York: Van Nostrand Reinhold; 1989:61-456.
11. Wilking SL, Husberg ML, Ko CU, Wick SM. The effect of excipients on the mechanical properties of selected acrylate, poloisobutylene and silicone pressure sensitive adhesives commonly utilised in transdermal drug delivery systems. Pharm Res. 1994;11(suppl 226).
12. Peterson, HF. Engineered Materials Handbook, Vol. 3, Adhesives and Sealants. USA:ASM International; 1990:20-21.
13. Panaitescu LS, Dallas PP, Rekkas DM, Choulis NH. Optimization of the mechanical properties of a pressure sensitive adhesive containing penetration enhancers. Proc Int Symp Controlled-Release Bioact Mater. 1998;25:551-552.