Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

Diabetologia

Volumn 47, Issue 3, 2004, Pages 451-462

  Giulietti, A ^a   Gysemans, C ^a   Stoffels, K ^a   Van Etten, E ^a   Decallonne, B ^a   Overbergh, L ^a   Bouillon, R ^a   Mathieu, C ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Islets; Macrophage; NOD; Prevention; Rickets; Type 1 diabetes; Vitamin D

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 1; INTERLEUKIN 15; INTERLEUKIN 6; PADGEM PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET; DISEASE EXACERBATION; FEMALE; GLUCOSE INTOLERANCE; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; INTERMETHOD COMPARISON; MACROPHAGE; MALE; MOUSE; NONHUMAN; OBESITY; PERITONEUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; VITAMIN D DEFICIENCY;

ANIMALS; BODY WEIGHT; CALCITRIOL; CALCIUM; DIABETES MELLITUS, TYPE 1; FEMALE; MALE; MICE; MICE, INBRED NOD; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VITAMIN D DEFICIENCY;

EID: 1842844448     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1329-3     Document Type: Article

References (48)

1. Akerblom HK, Vaarala O, Hyoty H, Ilonen J, Knip M (2002) Environmental factors in the etiology of type 1 diabetes. Am J Med Genet 115:18-29
2. Hyttinen V, Kaprio J, Kinnunen L, Koskenvuo M, Tuomilehto J (2003) Genetic liability of Type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up study. Diabetes 52:1052-1055
3. Green A, Patterson CC (2001) Trends in the incidence of childhood-onset diabetes in Europe 1989-1998. Diabetologia 44 [Suppl 3]:B3-B8
4. Ponsonby AL, McMichael A, Mei I van der (2002) Ultraviolet radiation and autoimmune disease: insights from epidemiological research. Toxicology 181-182:71-78
5. Serrano-Rios M, Goday A, Martinez LT (1999) Migrant populations and the incidence of type 1 diabetes mellitus: an overview of the literature with a focus on the Spanish-heritage countries in Latin America. Diabetes Metab Res Rev 15:113-132
6. Feltbower RG, Bodansky HJ, McKinney PA, Houghton J, Stephenson CR, Haigh D (2002) Trends in the incidence of childhood diabetes in south Asians and other children in Bradford, UK. Diabet Med 19:162-166
7. Mathieu C, Van Etten E, Gysemans C et al. (2001) In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice. J Bone Miner Res 16:2057-2065
8. Van Etten E, Branisteanu DD, Overbergh L, Bouillon R, Verstuyf A, Mathieu C (2003) Combination of a 1,25-dihydroxyvitamin D(3) analog and a bisphosphonate prevents experimental autoimmune encephalomyelitis and preserves bone. Bone 32:397-404
9. Tsuji M, Fujii K, Nakano T, Nishii Y (1994) 1 alpha-hydroxyvitamin D3 inhibits type II collagen-induced arthritis in rats. FEBS Lett 337:248-250
10. Larsson P, Mattsson L, Klareskog L, Johnsson C (1998) A vitamin D analogue (MC 1288) has immunomodulatory properties and suppresses collagen-induced arthritis (CIA) without causing hypercalcaemia. Clin Exp Immunol 114:277-283
11. Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R (1994) Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 37:552-558
12. Casteels KM, Mathieu C, Waer M et al. (1998) Prevention of type I diabetes in nonobese diabetic mice by late intervention with nonhypercalcemic analogs of 1,25-dihydroxy-vitamin D3 in combination with a short induction course of cyclosporin A. Endocrinology 139:95-102
13. Mathieu C, Adorini L (2002) The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents. Trends Mol Med 8:174-179
14. The EURODIAB Substudy 2 Study Group (1999) Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. Diabetologia 42:51-54
15. Stene LC, Ulriksen J, Magnus P, Joner G (2000) Use of cod liver oil during pregnancy associated with lower risk of Type I diabetes in the offspring. Diabetologia 43:1093-1098
16. Harris S (2002) Can vitamin D supplementation in infancy prevent type 1 diabetes? Nutr Rev 60:118-121
17. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM (2001) Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358:1500-1503
18. Verhaeghe J, Van Herck E, Van Bree R, Van Assche FA, Bouillon R (1989) Osteocalcin during the reproductive cycle in normal and diabetic rats. J Endocrinol 120:143-151
19. Gysemans C, Waer M, Laureys J et al. (2000) Islet xenograft destruction in the hu-PBL-severe combined immunodeficient (SCID) mouse necessitates anti-CD3 preactivation of human immune cells. Clin Exp Immunol 121:557-565
20. Mathieu C, Laureys J, Sobis H, Vandeputte M, Waer M, Bouillon R (1992) 1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice. Diabetes 41:1491-1495
21. Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, Mathieu C (2001) An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 25:386-401
22. Overbergh L, Valckx D, Waer M, Mathieu C (1999) Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 11:305-312
23. Chesney RW (2002) Rickets: the third wave. Clin Pediatr (Phila) 41:137-139
24. Gale EA (2002) The rise of childhood type 1 diabetes in the 20th century. Diabetes 51:3353-3361
25. Bar-Shavit Z, Noff D, Edelstein S, Meyer M, Shibolet S, Goldman R (1981) 1,25-dihydroxyvitamin D3 and the regulation of macrophage function. Calcif Tissue Int 33:673-676
26. Stroder J, Kasal P (1970) Evaluation of phagocytosis in rickets. Acta Paediatr Scand 59:288-292
27. Wientroub S, Winter CC, Wahl SM, Wahl LM (1989) Effect of vitamin D deficiency on macrophage and lymphocyte function in the rat. Calcif Tissue Int 44:125-130
28. Kankova M, Luini W, Pedrazzoni M et al. (1991) Impairment of cytokine production in mice fed a vitamin D3-deficient diet. Immunology 73:466-471
29. Jansen A, Homo-Delarche F, Hooijkaas H, Leenen PJ, Dardenne M, Drexhage HA (1994) Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice. Diabetes 43:667-675
30. Rosmalen JG, Martin T, Dobbs C et al. (2000) Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes. Lab Invest 80:23-30
31. Serreze DV, Gaskins HR, Leiter EH (1993) Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice. J Immunol 150:2534-2543
32. Alleva DG, Pavlovich RP, Grant C, Kaser SB, Beller DI (2000) Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice. Diabetes 49:1106-1115
33. Waldmann TA (2002) The IL-2/IL-15 receptor systems: targets for immunotherapy. J Clin Immunol 22:51-56
34. O'Brien BA, Huang Y, Geng X, Dutz JP, Finegood DT (2002) Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced. Diabetes 51:2481-2488
35. Bradley LM, Asensio VC, Schioetz LK et al. (1999) Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J Immunol 162:2511-2520
36. Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL (2001) Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Diabetologia 44:325-332
37. Cardozo AK, Proost P, Gysemans C, Chen MC, Mathieu C, Eizirik DL (2003) IL-1beta and IFN-gamma induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. Diabetologia 46:255-266
38. Herbelin A, Gombert JM, Lepault F, Bach JF, Chatenoud L (1998) Mature mainstream TCR alpha beta+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse. J Immunol 161:2620-2628
39. Weets I, Van Autreve J, Van der Auwera BJ et al. (2001) Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index. Diabetologia 44:40-47
40. Bruining GJ (2000) Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Netherlands Kolibrie study group of childhood diabetes. Lancet 356:655-656
41. Hypponen E, Virtanen SM, Kenward MG, Knip M, Akerblom HK (2000) Obesity, increased linear growth, and risk of type 1 diabetes in children. Diabetes Care 23:1755-1760
42. Gedik O, Akalin S (1986) Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 29:142-145
43. Kadowaki S, Norman AW (1984) Dietary vitamin D is essential for normal insulin secretion from the perfused rat pancreas. J Clin Invest 73:759-766
44. Nyomba BL, Bouillon R, De Moor P (1984) Influence of vitamin D status on insulin secretion and glucose tolerance in the rabbit. Endocrinology 115:191-197
45. Baynes KC, Boucher BJ, Feskens EJ, Kromhout D (1997) Vitamin D, glucose tolerance and insulinaemia in elderly men. Diabetologia 40:344-347
46. Boucher BJ (1998) Inadequate vitamin D status: does it contribute to the disorders comprising syndrome 'X'? Br J Nutr 79:315-327
47. Mathieu C, Van Etten E, Gysemans C, Decallonne B, Bouillon R (2002) Seasonality of birth in patients with type 1 diabetes. Lancet 359:1248
48. Mathieu C, Waer M, Casteels K, Laureys J, Bouillon R (1995) Prevention of type I diabetes in NOD mice by nonhypercalcemic doses of a new structural analog of 1,25-dihydroxyvitamin D3, KH1060. Endocrinology 136:866-872