Pyridazines. Part 31: Synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 12, 2002, Pages 1574-1577

  Sotelo, Eddy ^a   Fraiz, Nuria ^a   Yáñez, Matilde ^a   Laguna, Reyes ^a   Cano, Ernesto ^a   Raviña, Enrique ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Platelet; Platelet aggregation; Platelet aggregation inhibitor; Pyridazinone

Indexed keywords

4 CYANO 5 (1' CYANOHYDROXYMETHYL) 6 PHENYL 3(2H) PYRIDAZINONE; 4 CYANO 5 ETHOXYCARBONYL 6 PHENYL 3(2H) PYRIDAZINONE; 4 CYANO 5 ISOPROPYLOXYCARBONYL 6 PHENYL 3(2H) PYRIDAZINONE; 4,5 DIAMINO 6 PHENYL 3(2H) PYRIDAZINONE; 5 AMINO 4 BROMO 6 PHENYL 3(2H) PYRIDAZINONE; 5 AMINO 4 IODO 6 PHENYL 3(2H) PYRIDAZINONE; 5 AMINO 4 NITROSO 6 PHENYL 3(2H) PYRIDAZINONE; 5 CARBOXY 4 CYANO 6 PHENYL 3(2H) PYRIDAZINONE; 5 CYANO 5 METHOXYCARBONYL 6 PHENYL 3(2H) PYRIDAZINONE; PYRIDAZINE DERIVATIVE; PYRIDAZINONE DERIVATIVE; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT;

ANTIPLATELET ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PHARMACEUTICAL ENGINEERING; SUBSTITUTION REACTION; THROMBOCYTE; THROMBOCYTE AGGREGATION INHIBITION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; THROMBOCYTE AGGREGATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 1842843341     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.1574     Document Type: Article

References (19)

1. For the previous paper in this series, see: Coelho A., Raviña E., Sotelo E., Synlett, 2002 (In press).
2. Davies M. J., Thomas A. C., Br. Heart J., 53, 363-369 (1985).
3. Fuster V., Badimon L., Badimon J. J., Chesebro J. H., N. Engl. J. Med., 326, 242-249 (1992).
4. Moos W. H., Humblet C. C., Sircar I., Rithner C., Weishar R. E., Bristol J. A., McPhail A. J., J. Med. Chem., 38, 1990-1997 (1995) and references cited therein.
5. Frank H., Heinisch G., "Progress in Medicinal Chemistry," ed. by Ellis G. P., Luscombe D. K., Elsevier, Amsterdam, 29, 141 (1992).
6. Laguna R., Montero A., Cano E., Raviña E., Sotelo E., Estévez I., Acta Pharmaceutica Hungarica, 66, S43-S45 (1996)
7. [Chem. Abstr., 126, 165993 (1996)].
8. Laguna R., Rodriguez-Liñares B., Cano E., Estévez I., Raviña E., Sotelo E., Chem. Pharm. Bull., 45, 1151-1155 (1997).
9. Montero-Lastres A., Fraiz N., Laguna R., Cano E., Estévez I., Raviña E., Biol. Pharm. Bull., 22, 1376-1379 (1999).
10. Sotelo E., Fraiz N., Yañez M., Laguna R., Cano E., Brea J. M., Raviña E., Bioorg. & Med. Chem. Lett., 12, 1575-1577 (2002).
11. Sotelo E., Fraiz N., Yáñez M., Terrades V., Laguna R., Cano E., Raviña E., Bioorg. & Med. Chem., 10, 2873-2882 (2002).
12. Sotelo E., Raviña E., Estévez I., J. Heterocyclic Chem., 36, 985-990, (1999).
13. Estévez I., Raviña E., Sotelo E., J. Heterocyclic Chem., 35, 1421-1428 (1998).
14. Sotelo E., Pita B., Raviña E., Tetrahedron Lett., 41, 2863-2866 (2000).
15. Sotelo E., Centeno B. N., Rodrigo J., Raviña E., Tetrahedron, 58, 2389-2395 (2002).
16. Corey E. J., Gilman N. M., Ganem B. E., J. Am. Chem. Soc., 90, 5616-5617 (1968).
17. Lai G., Anderson W. K., Synth. Commun., 27, 1281-1283 (1997).
18. Born G. V. R., Nature (London), 194, 927-932 (1962).
19. De Kok T. M., Van Maanen J. M., Mutat. Res., 463, 53-101 (2000).