Prognostic Value of Cytosolyc Cathepsin D Content in Resectable Gastric Cancer

Journal of Surgical Oncology

Volumn 86, Issue 1, 2004, Pages 16-21

  Del Casar, José Manuel ^a   Vizoso, Francisco José ^a,b   Abdel Laa, Omar ^c   Sanz, Lourdes ^c   Martín, Aranzazu ^b   Corte, María Daniela ^b   Bongera, Miguel ^a   Muñiz, José Luis García ^b,c   Fueyo, Antonio ^b  

^a HOSPITAL DE JOVE   (Spain)

^b DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^c HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

Cathepsin D; Gastric cancer; Metastasis; Prognosis; Tumor invasion

Indexed keywords

ASPARTIC PROTEINASE; CYTOCHALASIN D; CYTOPLASM PROTEIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNORADIOMETRIC ASSAY; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN CONTENT; PROTEIN METABOLISM; STOMACH ADENOCARCINOMA; STOMACH CANCER;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CATHEPSIN D; CYTOSOL; FEMALE; GASTRECTOMY; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; STOMACH NEOPLASMS; SURVIVAL ANALYSIS;

EID: 1842841176     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/jso.20041     Document Type: Article

References (30)

1. Allgayer H, Babic R, Grutzner KU, et al.: Tumor-associated proteases and inhibitors in gastric cancer: Analysis of prognostic impact and individual risk protease patterns. Clin Exp Metastasis 1998;16:62-73.
2. Westley BR, May FEB: Cathepsin D and breast cancer. Eur J Cancer 1996;32A:15-24.
3. Diment S, Leech MS, Stahl PD: Cathepsin D is membrane associate in macrophage endosomes. J Biol Chem 1988;263:6901-6907.
4. Saftig P, Hetman M, Schmahl W, et al.: Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J 1995;14:3599-3608.
5. Rochefort H, Capony F, Garcia M, et al.: Estrogen-induced lysosomal proteases secreted by breast cancer cells: A role in carcinogenesis? J Cell Biochem 1987;35:17-29.
6. Briozzo P, Morisset M, Capony F, et al.: In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells. Cancer Res 1988;48:3688-3692.
7. Briozzo P, Badet J, Capony F, et al.: MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: A permissive role of cathepsin D. Exp Cell Res 1991;194:252-259.
8. Liaudet E, Derocq D, Rochefort H, et al.: Transfected cathepsin D stimulates high density cancer cell growth by inactivating secreted growth inhibitors. Cell Growth Differ 1995;6:1045-1052.
9. Mirza AN, Mirza NQ, Vlastos G, et al.: Prognostic factors in node-negative breast cancer: A review of studies with sample size more than 200 and follow-up more than 5 years. Ann Surg 2002;235:10-26.
10. Foekens JA, Look MP, Bolt-de Vries J, et al.: Cathepsin-D in primary breast cancer: Prognostic evaluation involving 2810 patients. Br J Cancer 1999;79:300-307.
11. Ikeguchi M, Fukuda K, Oka S, et al.: Clinicopathological significance of cathepsin D expression in gastric carcinoma. Oncology 2001;61:71-78.
12. Ikeguchi M, Fukuda K, Oka S, et al.: Micro-lymph node metastasis and its correlation with cathepsin D expression in early gastric cancer. J Surg Oncol 2001;77:188-194.
13. Goishi H, Tanaka S, Haruma K, et al.: Predictive value of cathepsin D and Ki-67 expression at the deepest penetration site for lymph node metastasis in gastric cancer. Oncol Rep 2000;7:713-718.
14. Allgayer H, Babic R, Grützner KU, et al.: An immunohistochemical assessment of cathepsin D in gastric carcinoma. Its impact on clinical prognosis. Cancer 1997;80:179-187.
15. Hermanek P, Sobin LJ: UICC TNM classification of malignant tumors. 4th edn. 2nd rev. Berlin: Springer; 1992.
16. Lauren R: The two histological main types of gastric carcinoma: The diffuse and so-called intestinal type carcinoma. Acta Pathol Microbiol Scand 1965;64:31-34.
17. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
18. García I, Vizoso F, Suárez C, et al.: Relationship of tumoral hyaluronic acid and cathepsin D contents with histological type of gastric carcinoma. Int J Biol Markers 2000;15:215-218.
19. Matsuo K, Kobayashi I, Tsukuba T, et al.: Immunohistochemical localization of cathepsins D and E in human gastric cancer: A possible correlation with local invasive and metastatic activities of carcinoma cells. Hum Pathol 1996;27:184-190.
20. Kashida H, Kawamata H, Ichikawa K, et al.: Intracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma. J Gastroenterol 2001;36:809-815.
21. Russo A, Bazan V, Migliavacca M, et al.: Prognostic significance of DNA ploidy, S-phase fraction, and tissue levels of aspartic, cysteine, and serine proteases in operable gastric carcinoma. Clin Cancer Res 2000;6:178-184.
22. Watanabe M, Higashi T, Hashimoto M, et al.: Elevation of tissue cathepsin B and L activities in gastric cancer. Hepatogastroenterology 1987;34:120-122.
23. Garcia M, Derocq D, Pujol P, et al.: Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency. Oncogene 1990;5:1809-1814.
24. Liaudet E, Garcia M, Rochefort H: Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal. Oncogene 1994;9:1145-1154.
25. van der Stappen JW, Williams AC, Maciewicz RA, et al.: Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D. Int J Cancer 1996;67:547-554.
26. Kobayashi Y, Fukuo Y, Shibuya T, et al.: The correlation between the activity of tissue plasminogen activator (TPA), levels of tissue plasminogen activator inhibitor (PAI-1) antigen and serum lipids in healthy subjects. Nippon Ronen Igakkai Zasshi 1990;27:578-583.
27. Griffiths JR: Are cancer cells acidic? Br J Cancer 1991;64:425-427.
28. Silver IA, Murrills RJ, Etherington DJ: Microelectrode studies on the acid microenvironment beneath adherent macrophages on osteoclasts. Exp Cell Res 1988;175:266-276.
29. Coopman PJ, Do MT, Thompson EW, et al.: Phagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacity. Clin Cancer Res 1998;4:507-515.
30. Rochefort H, Liaudet-Coopman E: Cathepsin D in cancer metastasis: A protease and a ligand. APMIS 1999;107:86-95.