Pharmacological doses of Zn2+ induce a muscarinic cholinergic supersensitivity.

Journal of biomedical science

Volumn 9, Issue 6, 2002, Pages 639-644

  Bonfante Cabarcas, R ^a   Bravo, I ^a   Nello, C ^a   Gutierrez Reyes E ^a   Loureiro Dos Santos, N E ^a   Moreno Yanes, J A ^a  

^a UNIVERSIDAD CENTROCCIDENTAL LISANDRO ALVARADO   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC RECEPTOR; ZINC;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; BRAIN LEVEL; DRUG EFFECT; MALE; MEMORY; MOTOR ACTIVITY; RAT; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; MALE; MEMORY; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; UP-REGULATION; ZINC;

EID: 1842836623     PISSN: 10217770     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02254992     Document Type: Article

References (35)

1. Acton G, Dailey JW, Morris SW, McNatt L. Evidence for an endogenous factor interfering with antagonist binding at the muscarinic cho­linergic receptor. Eur J Pharmacol 58:343-344; 1979.
2. Bartus RT, Dean RL 3rd, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-414;1982.
3. Brauner-Osborne H, Brann MR. Pharmacolo­gy of muscarinic acetylcholine receptor sub­types (ml-m5): High throughput assays in mammalian cells. Eur J Pharmacol 295:93-102;1996.
4. Cain DP. Testing the NMDA, long-term poten­tiation, and cholinergic hypothesis of spatial learning. Neurosci Biobehav Rev 22:181-193; 1998.
5. Caulfield MP, Birdsall NJ. International Uni­on of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 2:279-290;1998.
6. Cousins RJ. A role of zinc in the regulation of gene expression. Proc Nutr Soc 57:307-311; 1998.
7. Cuajungco M, Lees G. Diverse effects of metal chelating agents on the neuronal cytotoxicity of zinc in the hippocampus. Brain Res 799:97-107;1998.
8. Díaz LE, Quintero CC, Sánchez LM, Garcia MA, Oviedo MA, Pascuzzo-Lima C, Bonfante RA, Moreno-Yanes JA. Comparación del efec­to de zinc y cobre sobre la unión de 3[H] QNB al receptor colinèrgico muscarínico humano. Bol Med Post 14:207-215; 1998.
9. Diaz-Arrastia R, Ashizawa T, Appel SH. En­dogenous inhibitor of ligand binding to the muscarinic acetylcholine receptor. J Neuro-chem 44:622-628; 1985.
10. Donaldson J, Pierre TS, Minnich JL, Barbeau A. Determination of Na+, K+, Mg2+, Cu2+, Zn2+, and Mn2‘ in rat brain regions. Can J Bio-chem 51:87-92; 1973.
11. Fibiger HC. Cholinergic mechanisms in learn­ing, memory and dementia: A review of recent evidence. Trends Neurosci 14:220-223; 1991.
12. Frederickson RE, Frederickson CJ, Danscher G. In situ binding of bouton zinc reversibly dis­rupts performance on a spatial memory task. Behav Brain Res 38:25-33; 1990.
13. Gainetdinov RR, Caron MG. Delineating muscarinic receptor functions. Proc Natl Acad Sci USA 96:12222-12223; 1999.
14. Golub MS, Keen CL, Gershwin ME, Hen-drickx AG. Developmental zinc deficiency and behavior. J Nutr 125(8 suppl):2263S-2271S; 1995.
15. Halas ES, Hunt CD, Eberhardt MJ. Learning and memory disabilities in young adult rats from mildly zinc deficient dams. Physiol Behav 37:451-458; 1986.
16. Keller KA, Chu Y, Grider A, Coffield JA. Sup­plementation with L-histidine during dietary zinc repletion improves short-term memory in zinc-restricted young adult male rats. J Nutr 130:1633-1640;2000.
17. Levey AI. Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease. Proc Natl Acad SciUSA93:13541-13546;1996.
18. Lewin B. Regulation of transcription: Factors that activate the basal apparatus. In: Genes V. New York, Oxford University Press, chapter 30,879-909; 1994.
19. Mattera R, Pitts BJ, Entman ML, Bimbaumer L. Guanine nucleotide regulation of a mamma­lian myocardial muscarinic receptor system. Evidence for homo-and heterotropic coopera­tivity in ligand binding analyzed by computer-assisted curve fitting. J Biol Chern 260:7410-7421;1985.
20. Moreno-Yanes JA, Díaz LE, Quintero CC. Efecto regulador del cobre sobre la función muscarínica del cerebro humano. Arch Venez Farmacol Ter 14:05-17; 1995.
21. Morris RGM, Garrud J, Rawlins NP, O’Keefe J. Place navigation impaired in rats with hippo­campal lesions. Nature 297:681-683; 1982.
22. Nukina I. Characteristics of muscarinic acetyl­choline receptors in rat brain. Acta Med Okayama 37:179-191; 1983.
23. Ploysangam A, Falciglia GA, Brehm BJ. Effect of marginal zinc deficiency on human growth and development. J Trop Pediatr 43:192-198; 1997.
24. Prothero LS, Mathie A, Richards CD. Puriner-gic and muscarinic receptor activates a com­mon calcium entry pathway in rat neocortical neurons and glial cells. Neuropharmacology 39:1768-1778:2000.
25. Rosoff ML, Nathanson NM. GATA factor­dependent regulation of cardiac m2 muscarinic acetylcholine gene transcription. J Biol Chem 273:9124-9129;1998.
26. Rouse ST, Marino MJ, Potter LT, Conn PJ, Levey AI. Muscarinic receptor subtypes in­volved in hippocampal circuits. Life Sci 64: 501-509;1999.
27. Santos NE, Rodriguez-Valenzuela CS, Bon-fante-Cabarcas RA, Pascuzzo-Lima C, More­no-Yanes JA. Partial characterization of en­dogenous modulators of muscarinic acetylcho­line receptors in human frontal cortex. Invest Clin 40:109-125;1999.
28. +) in­flux pathways couple acetylcholine receptor ac­tivation to catecholamine secretion from PC 12 cells. J Neurochem 75:1583-1589;2000.
29. Trombley PQ, Horning MS, Blakemore LJ. Interactions between carnosine and zinc and cooper: Implications for neuromodulation and neuroprotection. Biochemistry (Mose) 65:949-960;2000.
30. Turner TY, Soliman MRI. Effects of zinc on spatial reference memory and brain dopamine (Dj) receptor binding kinetics in rats. Prog Neuropsycopharmacol Biol Psychiatry 24: 1203-1217;2000.
31. Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev 73:79-1 18; 1993.
32. Van Der Zee EA, Luiten PG. Muscarinic ace­tylcholine receptors in the hippocampus, neo­cortex and amygdala: A review of immunocy­tochemical localization in relation to learning and memory. Prog Neurobiol 58:409-711; 1999.
33. Weiss JH, Sensi SL, Koh JY. Zn(2+): A novel ionic mediator of neural injury in brain dis­ease. Trends Pharmacol Sci 21:395-401 ;2000.
34. Xie X, Smart TG. A physiological role for endogenous zinc in rat hippocampal synaptic transmission. Nature 349:521-524; 1991.
35. Xie X, Smart TG. Modulation of long-term potentiation in rat hippocampal pyramidal neurons by zinc. Pflügers Arch 427:481-486; 1994.