Serum leptin levels in acromegaly - A significant role for adipose tissue and fasting insulin/glucose ratio

Medical Science Monitor

Volumn 8, Issue 10, 2002, Pages

  Bolanowski, Marek ^a   Milewicz, Andrzej ^a   Bidzińska, Bozena ^a   Jȩdrzejuk, Diana ^a   Daroszewski, Jacek ^a   Mikulski, Emil ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Acromegaly; Adipose tissue; Insulin resistance; Lanreotide; Leptin

Indexed keywords

ANGIOPEPTIN; GLUCOSE; GROWTH HORMONE; INSULIN; LEPTIN; SOMATOMEDIN C; SOMATOSTATIN DERIVATIVE;

ACROMEGALY; ADIPOSE TISSUE; ADULT; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; BODY FAT; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEIGHT; HUMAN; INSULIN BLOOD LEVEL; INSULIN METABOLISM; INSULIN RESISTANCE; MALE; PROTEIN BLOOD LEVEL; BLOOD; DIET RESTRICTION; METABOLISM; MIDDLE AGED; STATISTICS;

ACROMEGALY; ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; FASTING; FEMALE; GROWTH HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MALE; MIDDLE AGED; STATISTICS;

EID: 1842834334     PISSN: 12341010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Campfield LA, Smith FJ, Burn P: The ob protein (leptin) pathway - A link between adipose tissue mass and central neural networks. Horm Metab Res, 1996: 28: 619-632
2. Salbe AD, Nicolson M, Ravussin E: Total energy expenditure and the level of physical activity correlate with plasma leptin concentrations in five-year-old children. J Clin Invest, 1997; 99: 592-595
3. Schwartz MW, Seeley RJ, Campfield LA et al: Identification of targets of leptin action in rat hypothalamus. J Clin Invest, 1996; 98: 1101-1106
4. Collins S, Kuhn CM, Petro AE et al: Role of leptin in fat regulation. Nature, 1996; 380: 677
5. Larsson H, Elmstahl S, Berglund G, Ahren B: Evidence fur leptin regulation of food intake in humans. J Clin Endocrinol Metab, 1998; 83: 4382-4385
6. Isidori AM, Strollo F, More M et al: Leptin and aging: Correlation with endocrine changes in male and female healthy adult populations of different body weights. J Clin Endocrinol Metab, 2000; 85: 1954-1962
7. Havel PJ, Kasim-Karakas S, Mueller W et al: Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab, 1996; 81: 4406-4413
8. Bengtsson BA, Brummer R-JM, Eden S, Bosaeus I: Body composition in acromegaly. Clin Endocrinol, 1989; 30: 121-130
9. Salomon F, Cuneo RC, Hesp R, Sonksen PH: The effect of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med, 1989; 321: 1797-1803
10. Davidson MB: Effect of growth hormone on carbohydrate and lipid metabolism. Endocr Rev, 1987; 8: 115-131
11. Berneis K, Vosmeer S, Keller U: Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man. Eur J Endocrinol, 1996; 135: 663-665
12. Florkowski CM, Collier GR, Zimmet PZ et al: Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol, 1996; 45: 769-773
13. Karlsson C, Stenlof K, Johannsson G et al: Effects of growth hormone treatment on the leptin system and on energy expenditure in abdominally obese men. Eur J Endocrinol, 1998: 128: 408-414
14. Licinio J, Negrao AB, Mantzoros C et al: Sex differences in circulating human leptin pulse amplitude: Clinical implications. J Clin Endocrinol Metab, 1998; 83: 4140-4147
15. Lonnqvist F, Wennlund A, Arner P: Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int J Obesity, 1997; 21: 255-260
16. Miyakawa M, Tsushima T, Murakami H et al: Effect of growth hormone (GH) on serum concentrations of leptin: Study in patients with acromegaly and GH deficiency. J Clin Endocrinol Metab, 1998; 83: 3476-3479
17. Damjanovic SS, Petakov MS, Raicevic S et al: Serum leptin levels in patients with acromegaly before and after correction of hypersomatotropism by trans-sphenoidal surgery. J Clin Endocrinol Metab, 2000; 85: 147-154
18. Gill MS, Toogood AA, Jones J et al: Serum leptin response to acute and chronic administration of growth hormone (GH) to elderly subjects with GH deficiency. J Clin Endocrinol Metab, 1999; 84: 1288-1295
19. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol, 1979; 273: E214-E223
20. Katz A, Nambi SS, Mather K et al: Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab, 2000; 85: 2402-2410
21. Matthews DR, Hosker JP, Rudenski AS et al: Homeostasis model assessment: Insulin resistance and a-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 1985; 28: 412-419
22. Bolanowski M, Bohdanowicz-Pawlak A, Bednarek-Tupikowka G et al: Serum glucose and insulin in acromegaly. The effect of treatment with Parlodel LAR. In: Pituitary Adenomas: From Basic Research to Diagnosis and Therapy. K von Werder and R Fahlbusch (eds), Elsevier Sciences BV, 1996; 69-76
23. Ho KKY, Jenkins AB, Furler SM et al: Impact of octreotide, a long-acting somatostatin analogue, on glucose tolerance and insulin sensitivity in acromegaly. Clin Endocrinol, 1992; 36: 271-279
24. Tan KCB, Tso AWK, Lam KSL: Effect of Sandostatin LAR on serum leptin levels in patients with acromegaly. Clin Endocrinol, 2001; 54: 31-35
25. Donahoo WT, Jensen DR, Yost TJ, Eckel RH: Isoproterenol and somatostatin decrease plasma leptin in humans: A novel mechanism regulating leptin secretion. J Clin Endocrinol Metab, 1997; 82: 4139-4143