Targeted overexpression of growth hormone by adenoviral gene transfer preserves myocardial function and ventricular geometry in ischemic cardiomyopathy

Journal of Molecular and Cellular Cardiology

Volumn 36, Issue 4, 2004, Pages 531-538

  Jayasankar, Vasant ^a   Pirolli, Timothy J ^a   Bish, Lawrence T ^a   Berry, Mark F ^a   Burdick, Jeffrey ^a   Grand, Todd ^a   Woo, Y Joseph ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Gene therapy; Growth factors; Heart failure; Remodeling

Indexed keywords

ADENOVIRUS VECTOR; GROWTH HORMONE;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DIASTOLE; EXPERIMENTAL RAT; GENE TRANSFER; GENE VECTOR; GEOMETRY; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART VENTRICLE FUNCTION; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HUMAN; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; SYSTOLE;

ADENOVIRIDAE; ANIMALS; CARDIOMYOPATHIES; DIASTOLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GROWTH HORMONE; HEART; HEART VENTRICLES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIUM; RATS; RATS, INBRED LEW; SYSTOLE; TIME FACTORS; TRANSGENES; VENTRICULAR REMODELING;

ADENOVIRIDAE; ANIMALIA;

EID: 1842815858     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2004.01.010     Document Type: Article

References (37)

1. Greenberg H., McMaster P., Dwyer E.M. Left ventricular dysfunction after acute myocardial infarction: Results of a prospective multicenter study. J Am Coll Cardiol. 5:1984;867-884.
2. White H.D., Norris R.M., Brown M.A., Brandt P.W., Whitlock R.M., Wild C.J. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation. 76:1987;44-51.
3. Pfeffer M.A., Braunwald E. Ventricular Remodeling after myocardial infarction - Experimental observation and clinical implications. Circulation. 81:1990;1161-1172.
4. Mitchell G.F., Lamas G.A., Vughan D.E., Pfeffer M.A. Left ventricular remodeling in the year after first anterior myocardial infarction. J Am Coll Cardiol. 19:1992;1136-1144.
5. Weisman H.F., Bush D.E., Mannisi J.A., Weisfeldt M.L., Healy B. Cellular mechanism of myocardial infarct expansion. Circulation. 78:1988;186-201.
6. Adamafio N.A., Towns R.J., Kostyo J.L. Growth hormone receptors and action in BC3H-1 myocytes. Growth Regul. 1:1991;17-22.
7. Haro L.S., Bustamante J., Hernandez P., Flores R., Aguilar R., Lopex-Guajardo C., Martinez A.O. Biochemistry and pharmacology of rabbit cardiac growth hormone (GH) receptors. Molec Cell Endocrinol. 152:1999;179-187.
8. Mathews L.S., Enberg B., Norstedt G. Regulation of rat growth hormone receptor gene expression. J Biol Chem. 264:1989;9905-9910.
9. Cittadini A., Stromer H., Katz S.E., Clark R., Moses A.C., Morgan J.P., Douglas P.S. Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. Circulation. 93:1996;800-809.
10. Timsit J., Riou B., Bertherat J., Wisnewsky C., Kato N.S., Weisberg A.S., Lubetzki J., Lecarpentier Y., Winegrad S., Mercadier J.J. Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle. J Clin Invest. 86:1990;507-515.
11. Mayoux E., Ventura-Clapier R., Timsit J., Behar-Cohen F., Hoffman C., Mercadier J.J. Mechanical properties of rat cardiac skinned fibers are altered by chronic growth hormone hypersecretion. Circ Res. 72:1993;57-64.
12. Tajima M., Weinberg E.O., Bartunek J., Jin H., Yang R., Paoni N.F., Lorrell B.H. Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure. Circulation. 99:1999;127-134.
13. Yang R., Bunting S., Gillett N., Clark T., Jin H. Growth hormone improves cardiac performance in experimental heart failure. Circulation. 92:1995;262-267.
14. Tivesten A., Caidahl K., Kujacic V., Sun X.Y., Hedner T., Bengtsson B.A., Isgaard J. Similar cardiovascular effects of growth hormone and insulin-like growth factor-I in rats after experimental myocardial infarction. Growth Horm IGF Res. 11:2001;187-195.
15. Jin H., Yang R., Lu H., Ogasawara A.K., Li W., Ryan A., Peale F., Paoni N.F. Effects of early treatment with growth hormone on infarct size, survival, and cardiac gene expression after acute myocardial infarction. Growth Horm IGF Res. 12:2002;208-215.
16. Melmed S., Jackson I., Kleinberg D., Klibanski A. Current treatment guidelines for acromegaly. J Clin Endocrinol Metab. 83:1998;2646-2652.
17. Fukuda I., Hizuka N., Murakami Y., Itoh E., Yasumoto K., Sata A., Takano K. Clinical features and therapeutic outcomes of 65 patients with acromegaly at Tokyo Women's Medical University. Intern Med. 40:2001;987-992.
18. Liu Y.-H., Yang X.-P., Nass O., Sabbah H.N., Peterson E., Carretero O.A. Chronic heart failure induced by coronary artery ligation in Lewis inbred rat. Am J Physiol. 272:1997;H722-H727.
19. Cittadini A., Isgaard J., Monti M.G., Casaburi C., Di Gianni A., Serpico R., Iaccarino G., Sacca L. Growth hormone prolongs survival in experimental postinfarction heart failure. J Am Coll Cardiol. 41:2003;2154-2163.
20. Caidahl K., Eden S., Gengtsson B.-A. Cardiovascular and renal effects of growth hormone. Clin Endocrinol (Oxf). 197:(40):1994;393-400.
21. Sacca L., Cittadini A., Fazio S. Growth hormone and the heart. Endocrin Rev. 15:1994;555-573.
22. McKay R.G., Pfeffer M.A., Pasternak R.C., Markis J.E., Come P.C., Nakao S., Alderman J.D., Ferguson J.J., Safian R.D., Grossman W. Left ventricular remodeling following myocardial infarction: a corollary to infarct expansion. Circulation. 74:1986;693-702.
23. Li Y., Takemura G., Kosai K.I., Yuge K., Nagano S., Esaki M., Goto K., Takahashi T., Kayakawa K., Koda M., Kawase Y., Maruyama R., Okada H., Minatoguchi S., Mizuguchi H., Fujiwara T., Tujiwara H. Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. Circulation. 107:2003;2499-2506.
24. Bichell D.P., Kikuchi K., Rotwein P. Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo. Molec Endocrinol. 6:1992;1899-1908.
25. Friberg L., Wener S., Eggertsen G., Ahnve S. Growth hormone and insulin-like growth factor-1 in acute myocardial infarction. Eur Heart J. 21:2000;1547-1554.
26. Froesch E.R., Schmid C., Schwander J., Zapf J. Actions of insulin-like growth factors. Annu Rev Physiol. 47:1985;443-467.
27. Donohue T.J., Dworkin L.D., Lango M.N., Fliegner K., Lango R.P., Benstein J.A., Slater W.R., Catanese V.M. Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy. Circulation. 89:1994;799-809.
28. Guse A.H., Kiess W., Funk B., Kessler U., Berg I., Gercken G. Identification and characterization of insulin-like growth factor receptors on adult rat myocytes: linkage to inositol-1,4,5-tris-phosphate formation. Endocrinology. 130:1992;145-151.
29. Krishnamurthi R.V., Maxwell L., Bassett N.S., Gavin J.B., Gluckman P.D., Johnston B.M. The spatial and temporal distribution of insulin-like growth factor-I following experimental myocardial infarction in the rat. Cardiovasc Pathol. 6:1997;197-203.
30. Osterziel K.J., Ranke M.B., Strohm O., Dietz R. The somatotrophic system in patients with dilated cardiomyopathy: relation of insulin-like growth factor-1 and its alterations during growth hormone therapy to cardiac function. Clin Endocrinol. 53:2000;61-68.
31. Fazio S., Sabatini D., Capaldo B., Vigorito C., Giordano A., Guida R., Pardo F., Biodi B., Sacca L. A preliminary study of growth hormone in the treatment of dilated cardiomyopathy. New Engl J Med. 334:1996;809-814.
32. Genth-Zotz S., Zotz R., Geil S., Voigtlander T., Meyer J., Darius H. Recombinant growth hormone therapy in patients with ischemic cardiomyopathy. Circulation. 99:1999;18-21.
33. Spallarossa P., Rossettin P., Minuto F., Caruso D., Cordera R., Battistini M., Barreca A., Masperone M.A., Brunelli C. Evaluation of growth hormone administration in patients with chronic heart failure secondary to coronary artery disease. Am J Cardiol. 84:1999;430-433.
34. Osterziel K.J., Strohm O., Schuler J., Friedrich M., Hanlein D., Willenbrock R., Anker S.D., Poole-Wilson P.A., Ranke M.B., Dietz R. Randomised, double-blind, placebo-controlled trial of human recombinant growth hormone in patients with chronic heart failure due to dilated cardiomyopathy. Lancet. 351:1998;1233-1237.
35. Isgaard J., Kujacic V., Jennische E., Holmang A., Sun X.Y., Hedner T., Hjalmarson A., Bengtsson B.A. Growth hormone improves cardiac function in rats with experimental myocardial infarction. Eur J Clin Invest. 27:1997;517-525.
36. Volterrani M., Desenzani P., Lorusso R., D'Aloia A., Manelli F., Giustina A. Haemodynamic effects of intravenous growth hormone in congestive heart failure. Lancet. 349:1997;1067-1068.
37. Hambrect R., Schulze P.C., Gielen S., Linke A., Mobius-Winkler S., Yu J., Kratzsch J.J., Baldauf G., Busse M.W., Schubert A., Adams V., Schuler G. Reduction of insulin-like growth factor-I expression in skeletal muscle of noncachetic patients with chronic heart failure. J Am Coll Cardiol. 39:2002;1175-1181.