Alterations in the immune system of children from mothers treated with immunosuppressive agents during pregnancy

Toxicology Letters

Volumn 149, Issue 1-3, 2004, Pages 155-162

  Cimaz, R ^a   Meregalli, E ^a   Biggioggero, M ^a   Borghi, O ^b   Tincani, A ^c   Motta, M ^c   Airo P ^c   Meroni, P L ^b  

^a ICP   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c SPEDALI CIVILI   (Italy)

Author keywords

Immune function; Immunosuppressants; Newborn; Pregnancy

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; CYCLOSPORIN; DEXAMETHASONE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSIVE AGENT;

ADOLESCENT; ANEMIA; ANTIBODY BLOOD LEVEL; BLOOD CELL COUNT; CELL SUBPOPULATION; CHILD; CLINICAL ARTICLE; CONFERENCE PAPER; CONNECTIVE TISSUE DISEASE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNE DEFICIENCY; IMMUNOSUPPRESSIVE TREATMENT; INFANT; LYMPHOCYTE COUNT; MALE; PREGNANCY; PRIORITY JOURNAL; THROMBOCYTOPENIA; VACCINATION;

ADULT; ASPIRIN; AUTOIMMUNE DISEASES; AZATHIOPRINE; CYCLOSPORINE; DEXAMETHASONE; FEMALE; HEMOGLOBINS; HEPATITIS ANTIBODIES; HEPATITIS B VACCINES; HUMANS; HYDROXYCHLOROQUINE; IMMUNE SYSTEM; IMMUNOGLOBULIN G; IMMUNOGLOBULINS; IMMUNOSUPPRESSIVE AGENTS; INFANT; INFANT, NEWBORN; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; PLATELET COUNT; PREDNISONE; PREGNANCY; VACCINATION;

EID: 1842716671     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2003.12.030     Document Type: Conference Paper

References (43)

1. Airò P., Antonioli C.M., Motta M., Faden D., Chirico G., Cattaneo R., Tincani A. The immune development in a child born to a cyclosporin A-treated woman with systemic lupus erythematosus/polymyositis. Lupus. 11:2002;454-457.
2. Arellano F., Monka C., Krupp P. Treatment with cyclosporine A in pregnancy. Med. Clin. 96:1991;194.
3. Armenti V.T., Ahlswede K.M., Ahlwede B.A. Variables affecting birthweight and graft survival in 197 pregnancies in cyclosporine-treated female kidney transplant recipients. Transplantation. 59:1995;476-479.
4. Armenti V.T., Moritz M.J., Davison J.M. Drug safety issues in pregnancy following transplantation and immunosuppression. Effects and outcomes. Drug Saf. 19:1998;219-232.
5. Baarsma R., Kamps W.A. Immunological responses in an infant after cyclosporine A exposure during pregnancy. Eur. J. Pediatr. 152:1993;476-477.
6. Bar Oz B., Hackman R., Einarson T., Koren G. Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis. Transplantation. 71:2001;1051-1055.
7. Cederqvist L.L., Merkatz I.R., Litwin S.D. Foetal immunoglobulin synthesis following maternal immunosuppression. Am. J. Obstet. Gynecol. 129:1977;687-690.
8. Chaouat G., Diallo J.T., Volumenie J.L., Menu E., Gras G., Delage G., Mognetti B. Immune suppression and Th1/Th2 balance in pregnancy revisited: a (very) personal tribute to Tom Wegmann. AJRI. 37:1997;427-434.
9. Classen J.B., Shevach E.M. Evidence that cyclosporine treatment during pregnancy predisposes offspring to develop autoantibodies. Transplantation. 51:1991;1052-1057.
10. Classen J.B. Cyclosporine induced autoimmunity in newborns prevented by early immunization. Autoimmunity. 27:1998;135-139.
11. Coté C.J., Meuwissen H.G., Pickering R.J. Effects on the neonate of prednisone and azathioprine administered to the mother during pregnancy. J. Pediatr. 85:1974;324-328.
12. Davidson J.M., Dellagrammatikas H., Parkin J.M. Maternal azathioprine therapy and depressed hemopoiesis in the babies of renal allograft patients. Br. J. Obstet. Gynecol. 92:1985;233-239.
13. DeWitte D.B., Buick M.K., Cyran S.E. Neonatal pancytopenia and severe combined immunodeficiency associated with antenatal administration of azathioprine and prednisone. J. Pediatr. 105:1984;625-628.
14. Di Paolo S., Schena A., Morrone L.F., Manfredi G., Stallone G., Derosa G., Procino A., Schena F.P. Immunological evaluation during the first year of life of infants born to cyclosporine-treated female kidney transplant recipient. Transplantation. 69:2000;2049-2054.
15. Ersay A., Oygür N., Cpskun M., Süleymanlar G., Track B., Yegin O. Immunologic evaluation of a neonate born to an immunosuppressed kidney transplant recipient. Am. J. Perinatol. 12:1995;413.
16. Flechner S.M., Kartz A.R., Rogers A.J., Van Buren C., Kahan B.D. The presence of cyclosporine in body tissues and fluids during pregnancy. Am. J. Kidney. 5:1985;60-63.
17. Gitau R., Cameron A., Fisk N.M., Glover V. Foetal exposure to maternal cortisol. Lancet. 352:1998;707-708.
18. Harris E.N. Antirhematic drugs in pregnancy. Lupus. 11:2002;683-689.
19. Hess A.D., Horwitz I., Beschorner W.E., Santos G.W. Development of a graft-versus-host disease-like syndrome in cyclosporine-treated rats after syngeneic bone marrow transplantations. Development of cytotoxic T lymphocytes with apparent polyclonal anti-La specificity, including autoreactivity. J. Exp. Med. 161:1985;718-724.
20. Hess A.D., Fischer A.C., Beschorner W.E. Effector mechanisms in cyclosporine A-induced syngeneic graft-versus-host disease. Role of CD4+ and CD8+ T lymphocyte subsets. J. Immunol. 145:1990;526-533.
21. Holladay S.D. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environ. Health Perspect. 107:1999;687-691.
22. Jain A., Venkataramanan R., Fung J.J., Gartner J.C., Lever J., Balan V., Warty V., Starzl T.E. Pregnancy after liver transplantation under tacrolimus. Transplantation. 64:1997;559-565.
23. Janssen N.M., Genta M. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch. Int. Med. 160:2000;610-619.
24. Kainz A., Harabacz I., Cowlrick I.S., Shirikant D.G., Hagiwara D. Review of the course and outcome of 100 pregnancies in 84 women treated with tacrolimus. Transplantation. 70:2000;1718-1721.
25. Kosugi A., Zuniga-Pflunker J.C., Sharrow S.O., Krulabeek A.M., Sheerer G.M. Effect of cyclosporin A on lymphopoiesis. Developmental effects on immature thymocytes in foetal thymus organ culture treated with cyclosporin A. J. Immunol. 143:1989;3134-3140.
26. Kozlowska-Boszko B., Korczak G., Wierzbicki P., Lis K., Gaciong Z., Lao M., Sicinska J., Gorski A. Pregnancy following kidney transplantation: risk for offsprings. Trasplantation Proc. 29:1997;262-265.
27. Little B.B. Immunosuppressant therapy during gestation. Seminars Perinatol. 21:1997;143-148.
28. Nandakumaran M., Eldeen A.S. Transfer of cyclosporine in the perfused human placenta. Dev. Pharmacol. Ther. 15:1990;101-105.
29. Nyberg G., Haljamäe U., Frisenette-Fich C., Wennergren M., Kjellmer I. Breast-feeding during treatment with cyclosporine. Trasplantation. 65:1998;253-255.
30. Ostensen M., Ramsey-Goldman R. Treatment of inflammatory rheumatic disorder in pregnancy. Drug Saf. 19:1998;390-410.
31. Padgett E.L., Seeling L.L. Jr. Effects on T-cell maturation and proliferation induced by lactational transfer of cyclosporine to nursing pups. Transplantation. 73:2002;867-874.
32. Petri M. Immunosuppressive drug use in pregnancy. Autoimmunity. 36:2003;51-56.
33. Pilarski L.M., Yacyshyn B.R., Lazarovits A.I. Analysis of peripheral blood lymphocyte populations and immune function from children exposed to cyclosporine or to azathioprine in utero. Trasplantation. 57:1994;133-144.
34. Prevot A., Martini S., Guignard J.P. In utero exposure to immunosuppressive drugs. Biol. Neonate. 81:2002;73-81.
35. Ramsey-Goldman R., Schilling E. Immunosuppressive drug use during pregnancy. Rheum. Dis. Clin. North. Am. 23:1997;149-167.
36. Rezzani R., Rodella L., Bianchi R. Cyclosporine and pregnancy in the rat. Trasplantation. 63:1997;164-167.
37. Rose M.L., Dominguez M., Levare N. Analysis of T-cell subpopulations and cyclosporine levels in the blood of two neonates born to immunosuppressed heart-lung transplant recipients. Transplantation. 48:1989;223-226.
38. Scott J.R. Risks to the children born to mothers with autoimmune disease. Lupus. 11:2002;655-660.
39. Takahashi N., Nishida H., Hoshi J. Severe B cell depletion in newborns from renal transplant mothers taking immunosuppressive agents. Transplantation. 57:1994;1617-1621.
40. Tendron A., Gouyon J.B., Decramer S. In utero exposure to immunosuppressive drug: experimental and clinical studies. Pediatr. Nephrol. 17:2002;121-130.
41. Thitu Y., Bateman D.N., Coulthard M.G. Successful breast feeding while mother was taking cyclosporine. BMJ. 315:1997;463.
42. Venkataramanan R., Koneru B., Wang C.C.P., Burckart G.J., Caritis S.N., Starzl T.E. Cyclosporine and its metabolites in mother and baby. Transplantation. 46:1988;468.
43. Von Hertzen L.C. Maternal stress and T-cell differentiation of the developing immune system: possible implications for the development of asthma and atopy. J. All. Clin. Immunol. 109:2002;923-928.