p-[123I]iodo-L-phenylalanine for detection of pancreatic cancer: Basic investigations of the uptake characteristics in primary human pancreatic tumour cells and evaluation in in vivo models of human pancreatic adenocarcinoma

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 31, Issue 4, 2004, Pages 532-541

  Samnick, Samuel ^a   Romeike, Bernd F M ^a   Kubuschok, Boris ^a   Hellwig, Dirk ^a   Amon, Michaela ^a   Feiden, Wolfgang ^a   Menger, Michael D ^a   Kirsch, Carl Martin ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Amino acids; Differential diagnosis; Pancreatic cancer; SCID mouse model; SPET imaging

Indexed keywords

ALANINE; AMINO ACID; CYSTEINE; IODINE 123; PHENYLALANINE; SERINE; 4 IODOPHENYLALANINE; 4-IODOPHENYLALANINE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

AMINO ACID TRANSPORT; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; DRUG DISTRIBUTION; EARLY DIAGNOSIS; EVALUATION; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENCE; IN VIVO STUDY; INCUBATION TIME; INFLAMMATION; ISOTOPE LABELING; MORTALITY; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PH MEASUREMENT; SCINTILLATION CAMERA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SURVIVAL RATE; TEMPERATURE MEASUREMENT; TUMOR CELL CULTURE; TUMOR LOCALIZATION; ADENOCARCINOMA; ANIMAL; ANTIBODY SPECIFICITY; COMPARATIVE STUDY; DRUG SCREENING; METABOLIC CLEARANCE RATE; METABOLISM; MOUSE; MOUSE MUTANT; PANCREAS TUMOR; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; TUMOR CELL LINE; VALIDATION STUDY;

ADENOCARCINOMA; ANIMALS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; HUMANS; METABOLIC CLEARANCE RATE; MICE; MICE, SCID; ORGAN SPECIFICITY; PANCREATIC NEOPLASMS; PHENYLALANINE; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION;

EID: 1842664914     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-003-1445-1     Document Type: Article

References (31)

1. Warshaw AW, Fernandez-del Castillo C. Pancreatic carcinoma. N Engl J Med 1992; 326:455-465.
2. Faivre J, Forman D, Esteve J, Obradovic M, Sant M. Survival of patients with primary liver cancer, pancreatic cancer and biliary tract cancer in Europe. Eur J Cancer 1998; 34:2184-2190.
3. Lillemore K. Current management of pancreatic cancer. Ann Surg 1995; 221:133-148.
4. Schafer M, Mullhaupt B, Clavien PA. Evidence-based pancreatic head resection for pancreatic cancer and chronic pancreatitis. Ann Surg 2002; 236:137-148.
5. Trümper L, Menges M, Daus H, Kohler D, Reinhard JO, Sackmann M, Moser C, Sek A, Jacobs G, Zeitz M, Pfreundschuh M. Low sensitivity of the ki-ras polymerase chain reaction for diagnosing pancreatic cancer from pancreatic juice and bile: a multicenter prospective trial. J Clin Oncol 2002; 21:4331-4337.
6. Mueller BM, Reisfeld RA. Potential of the scid mouse as a host for human tumors. Cancer Metastasis Rev 1991; 10:193-200.
7. Leblong V, Autran B, Cesbron JY. The SCID mouse mutant: definition and potential use as a model for immune and hematological disorders. Hematol Cell Ther 1997; 39:213-221.
8. Mohammad RM, Al-Katib A, Pettit GR, Vaitkevicius VK, Joshi U, Adsay V, Majumdar AP, Sarkar FH. An orthotopic model of human pancreatic cancer in severe combined immunodeficient mice: potential application for preclinical studies. Clin Cancer Res 1998; 4:887-894.
9. Nitzsche EU, Hoegerle S, Mix M, Brink I, Otte A, Moser E, Imdahl A. Non-invasive differentiation of pancreatic lesions: is analysis of FDG kinetics superior to semiquantitative uptake value analysis? Eur J Nucl Med Mol Imaging 2002; 29:237-242.
10. Grino P, Martinez J, Grino E, Carnicer F, Alonso S, Perez-Berenguer H, Perez-Mateo M. Acute pancreatitis secondary to pancreatic neuroendocrine tumours. JOP 2003; 4:104-110.
11. 18F-fluorodeoxyglucose-positron-emission tomography with preoperative evaluation of patients with pancreatic masses. Pancreas 2000; 20:109-116.
12. Laverman P, Boerman OC, Corstens FH, Oyen WJ. Fluorinated amino acids for tumour imaging with positron emission tomography. Eur J Nucl Med Mol Imaging 2002; 29:681-690.
13. Jager PL, Vaalburg W, Pruim J, de Vries EG, Langen KJ, Piers DA. Radiolabeled amino acids: basic aspects and clinical applications in oncology. J Nucl Med 2001; 42:432-445.
14. Kubota R, Kubota K, Yamada S, Tada M, Takahashi T, Iwata R, Tamahashi N. Methionine uptake by tumor tissue: a microautoradiographic comparison with FDG. J Nucl Med 1995; 36:484-492.
15. 18F]Fluoroethyl)-L-tyrosine (FET): a tracer for differentiation of tumour from inflammation in murine lymph nodes. Eur J Nucl Med Mol Imaging 2002; 29:1039-1046.
16. Lahoutte T, Mertens J, Caveliers V, Franken PR, Everaert H, Bossuyt A. Comparative biodistribution of iodinated amino acids in rats: selection of the optimal analog for oncologic imaging outside the brain. J Nucl Med 2003; 44:1489-1494.
17. Samnick S, Schaefer A, Siebert S, Richter S, Vollmar B, Kirsch CM. Preparation and investigation of tumor affinity, uptake kinetic and transport mechanism of iodine-123-labelled amino acid derivatives in human pancreatic carcinoma and glioblastoma cells. Nucl Med Biol 2001; 28:13-23.
18. Samnick S, Hellwig D, Gouverneur E, Romeike BF, Schneider G, Menger M, Kirsch CM. Evaluation of radioiodinated phenylalanine-analogues as radiopharmaceuticals to image pancreatic carcinomas in in-vivo models of human pancreatic tumors. Eur J Nucl Med Mol Imaging 2003; 30:S175.
19. Samnick S, Richter S, Romeike BF, Heimann A, Feiden W, Kempski O, Kirsch CM. Investigation of iodine-123-labelled amino acid derivatives for imaging cerebral gliomas: uptake in human glioma cells and evaluation in stereotactically implanted C6 glioma rats. Eur J Nucl Med 2000; 27:1543-1551.
20. Adachi T, Hinoda Y, Nishimori I, Adachi M, Imai K. Increased sensitivity of gastric cancer cells to natural killer and lymphokine-activated killer cells by antisense suppression of N-acetylgalactosaminyltransferase. J Immunol 1997; 159:2645-2651.
21. Schneider G, Fries P, Wagner-Jochem D, Thome D, Laurer H, Kramann B, Mautes A, Hagen T. Pathophysiological changes after traumatic brain injury: comparison of two experimental animal models by means of MRI. MAGMA 2002; 14:233-241.
22. Obuz F, Dicle O, Coker A, Sagol O, Karademir S. Pancreatic adenocarcinoma: detection and staging with dynamic MR imaging. Eur J Radiol 2001; 38:146-150.
23. DiMagno EP, Reber HA, Tempero MA. AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. American Gastroenterological Association. Gastroenterology 1999; 117:1464-1484.
24. Logsdon CD, Simeone DM, Binkley C, Arumugam T, Greenson JK, Giordano TJ, Misek DE, Hanash S. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 2003; 63:2649-2657.
25. 123I]Iodo-alpha-methyl-L-tyrosine: uptake mechanisms and clinical applications. Nucl Med Biol 2002; 29:625-631.
26. Miyagawa T, Oku T, Uehara H, Desai R, Beattie B, Tjuvajev J, Blasberg R. "Facilitated" amino acid transport is upregulated in brain tumors. J Cereb Blood Flow Metab 1998; 18:500-509.
27. Shotwell, MA, Kilberg MS, Oxender DL. The regulation of neutral amino acid transport in mammalian cells. Biochim Biophys Acta 1983; 737:267-284.
28. Saier MH, Daniels GA, Boerner P, Lin J. Neutral amino acid transport systems in animal cells: potential targets of oncogene action and regulators of cellular growth. J Membr Biol 1988; 104:1-20.
29. Segel GB, Woodlock TJ, Murant FG, Lichtman MA. Photoinhibition of 2-amino-2-carboxybicyclo[2,2,1] heptane transport by O-diazoacetyl-L-serine. An initial step in identifying the L-system amino acid transporter. J Biol Chem 1989; 264:16399-16402.
30. Barker GA, Wilkins RJ, Golding S, Ellory JC. Neutral amino acid transport in bovine articular chondrocytes. J Physiol 1999; 514:795-808.
31. Jara JR, Martinez-Liarte JH, Solano F, Penafiel R. Transport of L-tyrosine by B16/F10 melanoma cells: the effect of intracellular content of other amino acids. J Cell Sci 1990; 97:479-485.