Investigation of melt agglomeration process with a hydrophobic binder in combination with sucrose stearate

European Journal of Pharmaceutical Sciences

Volumn 19, Issue 5, 2003, Pages 381-393

  Heng, Paul Wan Sia ^a   Wong, Tin Wui ^a   Cheong, Wai See ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Hydrophobic meltable binder; Melt agglomeration; Specific volume; Sucrose stearate; Surface tension; Viscosity

Indexed keywords

ADHESION; AGGLOMERATION; BINDERS; COALESCENCE; CONTACT ANGLE; COTTONSEED OIL; GROWTH (MATERIALS); HYDROPHOBICITY; PARTICLE SIZE ANALYSIS; PLASTICITY; SURFACE PROPERTIES; SURFACE TENSION; VISCOSITY;

INTER-PARTICULATE BINDING STRENGTH;

DRUG PRODUCTS;

COTTON SEED OIL; HYDROGENATED COTTONSEED OIL; LACTOSE; STEARIC ACID DERIVATIVE; SUCROSE STEARATE; UNCLASSIFIED DRUG;

ARTICLE; BIOAVAILABILITY; HYDROGENATION; HYDROPHOBICITY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SURFACE PROPERTY; SURFACE TENSION; VISCOSITY;

EID: 0041620129     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00138-6     Document Type: Article

References (25)

1. Buckton G. Contact angle, adsorption and wettability - a review with respect to powders. Powder Technol. 61:1990;237-249.
2. Cliff M.J. Granulation end point and automated process control of mixer-granulators: part I. Pharm. Technol. 14:(4):1990;112-132.
3. Eliasen H., Kristensen H.G., Schæfer T. Growth mechanisms in melt agglomeration with a low viscosity binder. Int. J. Pharm. 186:1999;149-159.
4. Evrard B., Delattre L. In vitro evaluation of lipid matrices for the development of a sustained-release sulfamethazine bolus for lambs. Drug Dev. Ind. Pharm. 22:(2):1996;111-118.
5. Evrard B., Amighi K., Beten D., Delattre L., Moës A.J. Influence of melting and rheological properties of fatty binders on the melt granulation process in a high-shear mixer. Drug Dev. Ind. Pharm. 25:(11):1999;1177-1184.
6. Heng P.W.S., Wong T.W., Wan L.S.W. A new method for the control of size of pellets in the melt pelletization process with a high shear mixer. Chem. Pharm. Bull. 47:(5):1999;633-638.
7. Heng P.W.S., Wan L.S.C., Wong T.W. Effect of off-bottom clearance on properties of pellets produced by melt pelletization. Pharm. Dev. Technol. 4:(1):1999;27-33.
8. Heng P.W.S., Chan L.W., Zhu L. Effects of process variables and their interactions on melt pelletization in a high shear mixer. S.T.P. Pharma. 10:(2):2000;165-172.
9. Iveson S.M., Litster J.D. Fundamental studies of granule consolidation. Part 2: Quantifying the effects of particle and binder properties. Powder Technol. 99:1998;243-250.
10. Iveson S.M., Litster J.D., Hapgood K., Ennis B.J. Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review. Powder Technol. 117:2001;3-39.
11. Keningley S.T., Knight P.C., Marson A.D. An investigation into the effects of binder viscosity on agglomeration behaviour. Powder Technol. 91:1997;95-103.
12. Kiesvaara J., Yliruusi J. The use of Washburn method in determining the contact angles of lactose powder. Int. J. Pharm. 92:1993;81-88.
13. Lin K., Peck G.E. Development of agglomerated talc II: optimization of the processing parameters for the preparation of granulated talc. Drug Dev. Ind. Pharm. 21:1995;159-173.
14. Maejima T., Ohsawa T., Kobayashi M., Noda K. Factors effecting spherical granulation of drugs by tumbling granulation method. Chem. Pharm. Bull. 40:(2):1992;488-492.
15. McTaggart C.M., Ganley H.A., Sickmueller A., Walker S.E. The evaluation of formulation and processing conditions of a melt granulation process. Int. J. Pharm. 19:1984;139-148.
16. Prestidge C.A., Tsatouhas G. Wettability studies of morphine sulfate powders. Int. J. Pharm. 198:2000;201-212.
17. Schæfer T., Mathiesen C. Melt pelletization in a high shear mixer. VIII. Effects of binder viscosity. Int. J. Pharm. 139:1996;125-138.
18. Thies R., Kleinebudde P. Melt pelletization of a hygroscopic drug in a high shear mixer. Part 3. Effects of binder variation. Chem. Pharm. Bull. 49:(2):2001;140-146.
19. Thomsen L.J., Schæfer T., Kristensen H.G. Prolonged release matrix pellets prepared by melt pelletization. II. Hydrophobic substances as meltable binders. Drug Dev. Ind. Pharm. 20:(7):1994;1179-1197.
20. Voinovich D., Moneghini M., Perissutti B., Filipovic-Grcic J., Grabnar I. Preparation in high-shear mixer of sustained-release pellets by melt pelletisation. Int. J. Pharm. 203:2000;235-244.
21. Washburn E.W. The dynamics of capillary flow. Phys. Rev. 8:1921;273-283.
22. Wong T.W., Wan L.S.C., Heng P.W.S. Effects of physical properties of PEG 6000 on pellets produced by melt pelletization. Pharm. Dev. Technol. 4:(3):1999;449-456.
23. Wong T.W., Chan L.W., Heng P.W.S. Study of the melt pelletization process focusing on the micromeritic property of pellets. Chem. Pharm. Bull. 48:(11):2000;1639-1643.
24. Zhou F., Vervaet C., Remon J.P. Matrix pellets based on the combination of waxes, starches and maltodextrins. Int. J. Pharm. 133:1996;155-160.
25. Zhu, L., 2000. Melt pelletization in high shear mixer. M.Sc. Thesis. National University of Singapore, Singapore.