Electrophilic catalysis in nucleophilic substitution reactions in ionic liquids

Tetrahedron Letters

Volumn 45, Issue 18, 2004, Pages 3633-3634

  Cavazza, Marino ^a   Pietra, Francesco ^b  

^a UNIVERSITY OF PISA   (Italy)

^b NONE   (Italy)

Author keywords

Halotropones; Ionic liquid; Nucleophilic substitutions

Indexed keywords

1 BUTYL 3 METHYLIMIDAZOLIUM CHLORIDE; 2 BROMOTROPONE; 2 CHLOROTROPONE; 2 IODOTROPONE; 2 TOSYLOXYTROPONE; BROMINE DERIVATIVE; CHLORIDE; FLUORINE DERIVATIVE; IODINE DERIVATIVE; ION; LEWIS ACID; LITHIUM; LITHIUM CHLORIDE; POTASSIUM CHLORIDE; SODIUM CHLORIDE; TROPONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; EXTRACTION; LIQUID; RECYCLING; SUBSTITUTION REACTION; THIN LAYER CHROMATOGRAPHY;

EID: 1842635746     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.03.050     Document Type: Article

References (12)

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11. 2O, respectively, at reflux. In our hands such drastic conditions proved unsuitable for elaborated cycloheptatrienones, such as colchiceine, where a mixture of 9-chloroisocolchicide (8.3%) and 10-chlorocolchicide (18%) was obtained.
12. Cavazza M., Pietra F. J. Chem. Soc., Perkin Trans. 1. 1995;2657-2661. Our method described here is faster and cleaner than von E. Doering method, allowing improved yields (Table 1) and easy recovery of the products.