Optimal fraction collecting in preparative LC/MS

Journal of Combinatorial Chemistry

Volumn 6, Issue 2, 2004, Pages 159-164

  Rosentreter, Ulrich ^a   Huber, Udo ^b  

^a BAYER PHARMA AG   (Germany)

^b AGILENT TECHNOLOGIES   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTIC METHOD; ARTICLE; FRACTIONATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; ULTRAVIOLET RADIATION;

EID: 1842611098     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc034046a     Document Type: Article

References (12)

1. Leister, W.; Strauss, K.; Wisnoski, D.; Zhao, Z.; Lindsley, C. J. Comb. Chem. 2003, 5 (3), 322-329.
2. Isbell, J.; Xu, R.; Cai, Z.; Kassel, D. B. J. Comb. Chem. 2002, 4 (6), 600-611.
3. Xu, R.; Wang, T.; Isbell, J.; Cai, Z.; Sykes, C.; Brailsford, A.; Kassel, D. B. Anal. Chem. 2002, 74 (13), 3055-3062.
4. Schultz, L.; Garr, C. D.; Cameron, L. M.; Bukowski, Bioorg. Med. Chem. Lett. 1998, 8 (17), 2409-2414.
5. Edwards, C.; Hunter, D. J. J. Comb. Chem. 2003, 5 (1), 61-66.
6. Blom, K. F. J. Comb. Chem. 2002, 4 (4), 295-301.
7. Weller, H. N.; Young, M. G.; Michalczyk, S. J.; Reitnauer, G. H.; Cooley, R. S.; Rahn, P. C.; Loyd, D. J.; Fiore, D.; Fischman, S. J. Mol. Diversity 1997, 3 (1), 61-70.
8. Zeng, L.; Burton, L.; Yung, K.; Shushan, B.; Kassel, D. B. J. Chromatogr., A 1998, 794, 3-13.
9. Blom, K. F.; Sparks, R.; Doughty, J.; Everlof, J. G.; Haque, T.; Combs, A. P. J. Comb. Chem. 2003, 5 (5), 670-683.
10. Collection by UV has another advantage: because UV peaks are narrower, the volume of collected fractions is smaller. This leads to shorter evaporation times of the fractions in the following processing step.
11. Meyer, H.; Wehinger, E.; Bossert, F.; Scherling, D. Arzneim.-Forsch. 1983, 33 (1), 106-112.
12. Bossert, F.; Horstmann, H.; Meyer, H.; Vater, W. Arzneim.-Forsch. 1979, 29 (1), 226-229.