Cerebral edema associated with betaine treatment in classical homocystinuria

Journal of Pediatrics

Volumn 144, Issue 4, 2004, Pages 545-548

  Devlin, A M ^b   Hajipour, L ^b   Gholkar, A ^b   Fernandes, H ^b   Ramesh, V ^b   Morris, A A M ^a  

^a ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE;

ARTICLE; BRAIN EDEMA; CASE REPORT; CHILD; CONVALESCENCE; CRANIOTOMY; DECOMPRESSION SURGERY; DRUG WITHDRAWAL; EMERGENCY SURGERY; HOMOCYSTINURIA; HUMAN; MALE; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; SIDE EFFECT; WHITE MATTER;

EID: 1842607443     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2003.12.041     Document Type: Article

References (10)

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2. Wilcken DE, Wilcken B, Dudman NP, Tyrreil PA. Homocystinuria - the effect of betaine in the treatment of patients not responsive to pyridoxine. N Engl J Med 1983;309:448-53.
3. Surtees R, Bowron A, Leonard J. Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine β-synthase deficiency: the effect of treatment. Pediatr Res 1997;42:577-82.
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7. Allen RH, Stabler SP, Lindenbaum J. Serum betainem N, N-dimethylglycine and N-methylcysteine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism 1993;42:1448-60.
8. Fowler B, Kraus J, Packman S, Rosenberg LE. Homocystinuria: evidence for three distinct classes of cystathionine beta-synthase mutants in cultured fibroblasts. J Clin Invest 1978;61:645-53.
9. Cottington EM, LaMantia C, Stabler SP, Allen RH, Tangerman A, Wagner C, et al. Adverse event associated with methionine loading test. Arterioscler Thromb Vasc Biol 2002;22:1046-50.
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