Liposomes Containing Distamycins: Preparation, Characterization and Antiproliferative Activity

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 11, Issue 2, 2004, Pages 83-88

  Cortesi, Rita ^a   Romagnoli, R ^a   Menegatti, E ^a   Esposito, E ^a   Cervellati, F ^a   Nastruzzi, C ^b  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Antiproliferative Activity; Distamycin; Drug Delivery; Liposome

Indexed keywords

CHOLESTEROL; DISTAMYCIN A; DISTAMYCIN C16; LIPOSOME; PHOSPHATIDYLCHOLINE; PHOSPHORYLCHOLINE; POLYCARBONATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SYNTHESIS; ENCAPSULATION; EVAPORATION; FILTER; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; REVERSE PHASE EVAPORATION;

CELL DIVISION; CELL LINE, TUMOR; DISTAMYCINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH INHIBITORS; HUMANS; LIPOSOMES;

EID: 1842591234     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.1080/10717540490280516     Document Type: Article

References (16)

1. Agen, C., Sironi, A. M., Danesi, R., Costa, M., Bernardini, N., Paparelli, A., Della Torre, P., and Del Tacca, M. 1992. Characterization of the toxicity of distamycin derivatives on cancer cell lines and rat heart. Toxicology 75:209-219.
2. Baraldi, P. G., Romagnoli, R., Beria, I., Cozzi, P., Geroni, C., Mongelli, N., Bianchi, N., Mischiati, C., and Gambari, R. 2000. Synthesis and antitumor activity of new benzoheterocyclic derivatives of distamycin A. J. Med. Chem. 43:2675-2684.
3. Beran, M., Jeha, S., O'Brien, S., Estey, E., Vitek, L., Zurlo, M. G., Rios, M. B., Keating, M., and Kantarjian, H. 1998. Tallimustine, an effective antileukemic agent in a severe combined immunodeficient mouse model of adult myelogenous leukemia, induces remissions in a phase I study. Clin. Cancer Res. 4:53-59.
4. Chunbo, Y., Ying, W., Xiaomin, Y., Zuhong, L., and Juzheng, L. 1996. A novel structure observed on the phospholipid Langmuir-Blodgett bilayer by atomic force microscopy. Appl. Surf. Sci. 103:531-534.
5. Cortesi, R., Nastruzzi, C., Esposito, E. Menegatti, E., and Gambari, R. 1994. Liposome-associated retinoids: production and antiproliferative activity on neoplastic cells. Eur. J. Pharm. Sci. 2:281-291.
6. Cortesi, R., Gui, V., Gambari, R., and Nastruzzi, C. 1999. In vitro effect on human leukemic K562 cells of co-administration of liposome-associated retinoid and cytosine arabinoside (ara-C). Am. J. Hematol. 62:33-43.
7. Cozzi, P., and Mongelli, N. 1998. Cytotoxics derived from distamycin A and congeners. Curr. Pharm. Des. 4:181-201.
8. Cozzi, P., Beria, I., Caldarelli, M., Capolongo, L., Geroni, C., Mazzini, S., and Ragg, E. 2000. Phenyl sulfur mustard derivatives of distamycin A. Bioorg. Med. Chem. Lett. 10:1653-1656.
9. Cozzi, P. 2000. Recent outcome in the field of distamycin-derived minor groove binders. Farmaco 55:168-173.
10. Cozzi, P. 2001. A new class of cytotoxic DNA minor groove binders: alpha-halogenoacrylic derivatives of pyrrolecarbamoyl oligomers. Farmaco 56:57-65.
11. Lian, T., and Ho, R. J. Y. 2001. Trends and developments in liposome drug delivery systems. J. Pharm. Sci. 90:667-680.
12. Lozzio, C. B., and Lozzio, B. B. 1975. Human chronic myelogeneous leukemia cell line with positive Philadelphia chromosome. Blood 45:321-334.
13. Marchini, S., Broggini, M., Sessa, C., and D'Incalci, M. 2001. Development of distamycin-related DNA binding anticancer drugs. Expert. Opin. Invest. Drugs 10:1703-1714.
14. Punt, C. J., Humblet, Y., Roca, E., Dirix, L. Y., Wainstein, R., Polli, A., and Corradino, I. 1996. Tallimustine in advanced previously untreated colorectal cancer, a phase II study. Br. J. Cancer 73:803-804.
15. Tagliabue, G., Filippini, C., Ubezio, P., and D'Incalci, M. 1997. Combination of the new minor groove alkylator tallimustine and melphalan. Eur. J. Cancer 33:284-287.
16. Weiss, G. R., Poggesi, I., Rocchetti, M., DeMaria, D., Mooneyham, T., Reilly, D., Vitek, L. V., Whaley, F., Patricia, E., Von Hoff, D. D., and O'Dwyer, P. 1997. A phase I and pharmacokinetic study of tallimustine [PNU 152241 (FCE 24517)] inpatients with advanced cancer. Clin. Cancer Res. 3:2377-2384.