The Hemagglutinin-Neuraminidase Protein of Newcastle Disease Virus Determines Tropism and Virulence

Journal of Virology

Volumn 78, Issue 8, 2004, Pages 4176-4184

  Huang, Zhuhui ^a   Panda, Aruna ^a   Elankumaran, Subbiah ^a   Govindarajan, Dhanasekaran ^a   Rockemann, Daniel D ^a   Samal, Siba K ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; SIALIDASE;

ANIMAL CELL; ARTICLE; CHICKEN; CHIMERA; ENZYME ACTIVITY; HEMADSORPTION; IMMUNOHISTOCHEMISTRY; MOLECULAR RECOGNITION; NEWCASTLE DISEASE PARAMYXOVIRUS; NONHUMAN; PATHOGENICITY; PLANT GROWTH; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRAIN DIFFERENCE; VIROGENESIS; VIRUS CELL INTERACTION; VIRUS ISOLATION; VIRUS VIRULENCE;

ANIMALS; BASE SEQUENCE; CELL LINE; CERCOPITHECUS AETHIOPS; CHICK EMBRYO; CHIMERA; CYTOPATHOGENIC EFFECT, VIRAL; DNA, VIRAL; GENES, VIRAL; HN PROTEIN; HUMANS; MUTATION; NEWCASTLE DISEASE; NEWCASTLE DISEASE VIRUS; VERO CELLS; VIRULENCE;

EID: 1842588571     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.8.4176-4184.2004     Document Type: Article

References (48)

1. Alexander, D. J. 1989. Newcastle disease, p. 114-120. In H. G. Purchase, L. H. Arp, C. H. Domermuth, and J. E. Pearson (ed.), A laboratory manual for the isolation and identification of avian pathogens, 3rd ed. American Association for Avian Pathologists, Inc., Kennett Square, Pa.
2. Chare, E. R., E. A. Gould, and E. C. Holmes. 2003. Phylogenetic analysis reveals a low rate of homologous recombination in negative-sense RNA viruses. J. Gen. Virol. 84:2691-2703.
3. Collins, M. S., J. B. Bashiruddin, and D. J. Alexander. 1993. Deduced amino acid sequences at the fusion protein cleavage site of Newcastle disease viruses showing variation in antigenicity and pathogenicity. Arch. Virol. 128:363-370.
4. Collins, M. S., I. Strong, and D. J. Alexander. 1994. Evaluation of the molecular basis of the pathogenicity of the variant Newcastle disease viruses termed 'pigeon PMV-1 viruses.' Arch. Virol. 134:403-411.
5. Collins, M. S., I. Strong, and D. J. Alexander. 1996. Pathogenicity and phylogenetic evaluation of the variant Newcastle disease viruses termed 'pigeon PMV-1' viruses based on the nucleotide sequence of the fusion protein gene. Arch. Virol. 141:635-647.
6. Collins, M. S., S. J. Govey, and D. J. Alexander. 2003. Rapid assessment of the virulence of Newcastle disease virus isolates using the ligase chain reaction. Arch. Virol. 148:1851-1862.
7. Colman, P., and C. Ward. 1985. Structure and diversity of influenza virus neuraminidase. Curr. Top. Microbiol. Immunol. 114:178-254.
8. Crennell, S., T. Takimoto, A. Portner, and G. Taylor. 2000. Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase. Nat. Struct. Biol. 7:1068-1074.
9. Deng, R., Z. Wang, A. M. Mirza, and R. M. Iorio. 1995. Localization of a domain on the paramyxovirus attachment protein required for the promotion of cellular fusion by its homologous fusion protein spike. Virology 209:457-469.
10. Deng, R., Z. Wang, P. Mahan, M. Marinello, A. Mirza, and R. M. Iorio. 1999. Mutations in the Newcastle disease virus hemagglutinin-neuraminidase protein that interfere with its ability to interact with homologous F protein in the promotion of fusion. Virology 253:43-54.
11. Duprex, W. P., I. Duffy, S. McQuaid, L. Hamill, S. L. Cosby, M. A. Billeter, J. Schneider-Schaulies, V. ter Meulen, and B. K. Rima. 1999. The H gene of rodent brain-adapted measles virus confers neurovirulence to the Edmonston vaccine strain. J. Virol. 73:6916-6922.
12. Fujii, Y., T. Sakaguchi, K. Kiyotani, and T. Yoshida. 1999. Comparison of substrate specificities against the fusion glycoproteins of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases. Microbiol. Immunol. 43:133-140.
13. Gravel, K. A., and T. G. Morrison. 2003. Interacting domains of the HN and F proteins of Newcastle disease virus. J. Virol. 77:11040-11049.
14. Hernandez, L. D., L. R. Hoffmann, T. G. Wolfsberg, and J. M. White. 1996. Virus-cell and cell-cell fusion. Annu. Rev. Cell Biol. 12:627-661.
15. Hu, X. L., R. Ray, and R. W. Compans. 1992. Functional interactions between the fusion protein and hemagglutinin-neuraminidase of human parainfluenza viruses. J. Virol. 66:1528-1534.
16. Huang, Z., S. Krishnamurthy, A. Panda, and S. K. Samal. 2001. High-level expression of a foreign gene from the most Y-proximal locus of a recombinant Newcastle disease virus. J. Gen. Virol. 82:1729-1736.
17. Huang, Z., S. Krishnamurthy, A. Panda, and S. K. Samal. 2003. Newcastle disease virus V protein is associated with viral pathogenesis and functions as an alpha interferon antagonist. J. Virol. 77:8676-8685.
18. Iorio, R. M., R. J. Syddall, R. L. Glickman, A. M. Riel, J. P. Sheehan, and M. A. Bratt. 1989. Identification of amino acid residues important to the neuraminidase activity of the HN glycoproteins of Newcastle disease virus. Virology 173:196-204.
19. Iorio, R. M., R. L. Glickman, A. M. Riel, J. P. Sheehan, and M. A. Bratt. 1989. Functional and neutralization profile of seven overlapping antigenic sites on the HN glycoproteins of Newcastle disease virus: monoclonal anti-bodies to some sites prevent viral attachment. Virus Res. 13:245-261.
20. Kohn, A. 1965. Polykaryocytosis induced by Newcastle disease virus in monolayers of animal cells. Virology 26:228-245.
21. Krishnamurthy, S., Z. Huang, and S. K. Samal. 2000. Recovery of a virulent strain of Newcastle disease virus from cloned cDNA: expression of a foreign gene results in growth retardation and attenuation. Virology 278:168-182.
22. Lamb, R. A., and D. Kolakofsky. 1996. The paramyxoviruses, p. 577-604. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
23. Lana, D. P., D. B. Snyder, D. J. King, and W. W. Marquardt. 1988. Characterization of a battery of monoclonal antibodies for differentiation of Newcastle disease virus and pigeon paramyxovirus-1 strains. Avian Dis. 32:273-281.
24. Mayer, V., J. L. Schulman, and E. D. Kilbourne. 1973. Nonlinkage of neurovirulence exclusively to viral hemagglutinin or neuraminidase in genetic recombinants of A/NWS (H0N1) influenza virus. J. Virol. 11:272-278.
25. Mayo, M. A. 2002. A summary of taxonomic changes recently approved by ICTV. Arch. Virol. 147:1655-1656.
26. McGinnes, L. W., and T. G. Morrison. 1994. Modulation of the activities of HN protein of Newcastle disease virus by non-conserved cysteine residues. Virus Res. 34:305-316.
27. McGinnes, L. W., and T. G. Morrison. 1995. The role of individual oligosaccharide chains in the activities of the HN glycoprotein of Newcastle disease virus. Virology 212:398-410.
28. Mebatsion, T., S. Verstegen, L. T. C. de Vaan, A. Romer-Oberdorfer, and C. C. Schrier. 2001. A recombinant Newcastle disease virus with low-level V protein expression is immunogenic and lacks pathogenicity for chicken embryos. J. Virol. 75:420-428.
29. Mirza, A. M., R. T. Deng, and R. M. Iorio. 1994. Site-directed mutagenesis of a conserved hexapeptide in the paramyxovirus hemagglutinin-neuraminidase glycoproteins: effects on antigenic structure and function. J. Virol. 68:5093-5099.
30. Muster, T., E. K. Subbarao, M. Enami, B. R. Murphy, and P. Palase. 1991. An influenza A virus containing influenza B virus 5′ and 3′ noncoding regions on the neuraminidase gene is attenuated in mice. Proc. Natl. Acad. Sci. USA 88:5177-5181.
31. Nagai, Y. 1995. Virus activation by host proteinases. A pivotal role in the spread of infection, tissue tropism and pathogenicity. Microbiol. Immunol. 39:1-9.
32. Panda, A., Z. Huang., S. Elankumaran, D. D. Rockemann, and S. K. Samal. 2004. Role of fusion protein cleavage site in the virulence of Newcastle disease virus. Microb. Pathog. 36:1-10.
33. Peeters, B. P., O. S. de Leeuw, G. Koch, and A. L. Gielkens. 1999. Rescue of Newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence. J. Virol. 73:5001-5009.
34. Potier, M., L. Mameli, M. Belishem, L. Dallaire, and S. B. Melancon. 1979. Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-D-N-acetylneuraminate) substrate. Anal. Biochem. 94:287-296.
35. Prince, G. A., M. G. Ottolini, and A. Moscona. 2001. Contribution of the human parainfluenza virus type 3 HN-receptor interaction to pathogenesis in vivo. J. Virol. 75:12446-12451.
36. Rott, R., and H. D. Klenk. 1988. Molecular basis of infectivity and pathogenicity of Newcastle disease virus, p. 98-112. In D. J. Alexander (ed.), Newcastle disease. Kluwer Academic Publishers, Boston, Mass.
37. Schlesinger, R. W., P. J. Husak, G. L. Bradshaw, and P. P. Panayotov. 1998. Mechanisms involved in natural and experimental neuropathology of influenza viruses: evidence and speculation. Adv. Virus Res. 50:289-379.
38. Sergel, T., L. W. McGinnes, and T. G. Morrison. 2000. A single amino acid change in the Newcastle disease virus fusion protein alters the requirement for HN protein in fusion. J. Virol. 74:5101-5107.
39. Sheehan, J., and R. Iorio. 1992. A single amino acid substitution in the hemagglutinin-neuraminidase of Newcastle disease virus results in a protein deficient in both functions, Virology 189:778-781.
40. Sheela, R. R., U. Babu, J. Mu, S. Elankumaran, D. A. Bautista, R. B. Raybourne, R. A. Heckert, and W. Song. 2003. Immune responses against Salmonella enterica serovar Enteritidis infection in virally immunosuppressed chickens. Clin. Diagn. Lab. Immunol. 10:670-679.
41. Simons, K., and H. Garoff. 1980. The budding mechanisms of enveloped animal viruses. J. Gen. Virol. 50:1-21.
42. Smith, G. W., and L. E. Hightower. 1983. Biological consequences of neuraminidase deficiency in Newcastle disease virus. J. Virol. 47:385-391.
43. Stone-Hulslander, J., and T. G. Morrison. 1997. Detection of an interaction between the HN and F proteins in Newcastle disease virus-infected cells. J. Virol. 71:6287-6295.
44. Tanabayashi, K., and R. W. Compans. 1996. Functional interaction of paramyxovirus glycoproteins: identification of a domain in Sendai virus HN which promotes cell fusion. J. Virol. 70:6112-6118.
45. Tsurudome, M., M. Kawano, T. Yuasa, M. Nishio, H. Komada, and Y. Ito. 1995. Identification of regions on the hemagglutinin-neuraminidase protein of human parainfluenza virus type 2 important for promoting cell fusion. Virology 213:190-203.
46. von Itzstein, M., W. Y. Wu, G. B. Kok, M. S. Pegg, J. C. Dyason, B. Jin, T. V. Phan, M. L. Smythe, H. F. White, S. W. Oliver, P. M. Colman, J. N. Varghese, D. M. Ryan, J. M. Woods, R. C. Bethel, V. J. Hothman, J. M. Cameron, and C. R. Penn. 1993. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363:418-423.
47. Werner, O., A. Romer-Oberdorfer, B. Kollner, R. J. Manvell, and D. J. Alexander. 1999. Characterization of avian paramyxovirus type I strains isolated in Germany during 1992 to 1996. Avian Pathol. 28:79-88.
48. Yusoff, K., M. Nesbit, H. McCartney, P. T. Emmerson, and A. C. R. Samson. 1988. Mapping of three antigenic sites on the hemagglutinin-neuraminidase protein of Newcastle disease virus. Virus Res. 11:319-333.