Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite

Physiological Genomics

Volumn 2002, Issue 9, 2002, Pages 113-120

  Morimoto, Satoshi ^a   Cassell, Martin D ^a   Sigmund, Curt D ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Blood pressure; Neuron; Renin angiotensin system; Salt preference; Transgenic mouse

Indexed keywords

MUS MUSCULUS;

ANGIOTENSINOGEN; SODIUM CHLORIDE; SYNAPSIN;

ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD PRESSURE; BRAIN; CYTOLOGY; FOOD INTAKE; GENETICS; HUMAN; METABOLISM; MOLECULAR CLONING; MOUSE; NERVE CELL; PHYSIOLOGY; PROMOTER REGION; RAT; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ANGIOTENSINOGEN; ANIMALS; APPETITE REGULATION; BLOOD PRESSURE; BRAIN; CLONING, MOLECULAR; HUMANS; MICE; MICE, TRANSGENIC; NEURONS; PROMOTER REGIONS (GENETICS); RATS; SODIUM CHLORIDE; SYNAPSINS; TISSUE DISTRIBUTION;

EID: 0036359970     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00007.2002     Document Type: Article

References (37)

1. Bickerton RK and Buckley JP. Evidence for a central mechanism in angiotensin-induced hypertension. Proc Soc Exp Biol Med 106: 834-837, 1961.
2. Bunnemann B, Fuxe K, and Ganten D. The brain reninangiotensin system: localization and general significance. J Cardiovasc Pharmacol 19: S51-S62, 1992.
3. Catalanotto F, Schechter PJ, and Henkin RI. Preference for NaCl in the spontaneously hypertensive rat. Life Sci 11: 557-564, 1972.
4. Davisson RL, Oliverio MI, Coffman TM, and Sigmund CD. Divergent functions of angiotensin II receptor isoforms in brain. J Clin Invest 106: 103-106, 2000.
5. Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, and Sigmund CD. The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circ Res 83: 1047-1058, 1998.
6. Debus E, Weber K, and Osborn M. Monoclonal antibodies specific for glial fibrillary acidic (GFA) protein and for each of the neurofilament triplet polypeptides. Differentiation 25: 193-203, 1983.
7. DiNicolantonio R, Mendelsohn FAO, Hutchinson JS, Takata Y, and Doyle AE. Dissociation of dipsogenic and pressor responses to chronic central angiotensin II in rats. Am J Physiol Regul Integr Comp Physiol 242: R498-R504, 1982.
8. Fitts DA. Angiotensin II receptors in SFO but not in OVLT mediate isoproterenol-induced thirst. Am J Physiol Regul Integr Comp Physiol 267: R7-R15, 1994.
9. Fitts DA and Masson DB. Preoptic angiotensin and salt appetite. Behav Neurosci 104: 643-650, 1990.
10. Fitts DA, Tjepkes DS, and Bright RO. Salt appetite and lesions of the ventral part of the ventral median preoptic nucleus. Behav Neurosci 104: 818-827, 1990.
11. Geblert DR, Speth RC, and Wamsley JK. Quantitative autoradiography of angiotensin II receptors in the SHR brain. Peptides 7: 1021-1027, 1986.
12. 1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin. Regul Pept 49: 167-174, 1993.
13. Hatae T, Takimoto E, Murakami K, and Fukamizu A, Comparative studies on species-specific reactivity between renin and angiotensinogen. Mol Cell Biochem 131: 43-47, 1994.
14. Hoesche C, Sauerwald A, Veh RW, Krippl B, and Kilimann MW. The 5′-flanking region of the rat synapsin I gene directs neuron-specific and developmentally regulated reporter gene expression in transgenic mice. J Biol Chem 268: 26494-26502, 1993.
15. Imboden H, Harding JW, Hilgenfeldt U, Celio MR, and Felix D. Localization of angiotensinogen in multiple cell types of rat brain. Brain Res 410: 74-77, 1987.
16. Israel A and Saavedra JM. High angiotensin converting enzyme (kininase II) activity in the cerebrospinal fluid of spontaneously hypertensive adult rats. J Hypertens 5: 355-357, 1987.
17. Johren O, Inagami T, and Saavedra JM. AT1A, AT1B and AT2 angiotensin II receptor subtypes in rat brain. Neuroreport 6: 2549-2552, 1995.
18. Kakar SS, Riel KK, and Neill JD. Differential expression of angiotensin II receptor subtype mRNAs (AT-1A and AT-1B) in the brain. Biochem Biophys Res Commun 185: 688-692, 1992.
19. Keen HL and Sigmund CD. Paradoxical regulation of short promoter human renin transgene by Ang-II. Hypertension 37: 403-407, 2001.
20. Lee-Kirsch MA, Gaudet F, Cardoso MC, and Lindpaintner K. Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ Res 84: 240-246, 1999.
21. 125I-labelled MK351A. J Hypertens Suppl 2: S41-S44, 1984.
22. Merrill DC, Thompson MW, Carney C, Schlager G, Robillard JE, and Sigmund CD. Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. J Clin Invest 97:1047-1055, 1996.
23. Morimoto S, Cassell MD, Beltz TG, Johnson AK, Davisson RL, and Sigmund CD. Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circ Res 89: 365-372, 2001.
24. Mullen RJ, Buck CR, and Smith AM. NeuN, a neuronal specific nuclear protein in vertebrates. Development 116: 201-211, 1992.
25. Rowe BP, Grove KL, Saylor DL, and Speth RC. Angiotensin II receptor subtypes in the rat brain. Eur J Pharmacol 186: 339-342, 1990.
26. Sigmund CD. Manipulating genes to understand cardiovascular diseases: major approaches for introducing genes into cells. Hypertension 22: 599-607, 1993.
27. Sigmund CD, Jones CA, Kane CM, Wu C, Lang JA, and Gross KW. Regulated tissue-and cell-specific expression of the human renin gene in transgenic mice. Circ Res 70: 1070-1079, 1992.
28. Sinn PL, Davis DR, and Sigmund CD. Highly regulated cell-type restricted expression of human renin in mice containing 140 kb or 160 kb P1 phage artificial chromosome transgenes. J Biol Chem 274: 35785-35793, 1999.
29. Sinn PL and Sigmund CD. Identification of three human renin mRNA isoforms resulting from alternative tissue-specific transcriptional initiation. Physiol Genomics 3: 25-31, 2000.
30. Stornetta RL, Hawelu Johnson CL, Guyenet PG, and Lynch KR. Astrocytes synthesize angiotensinogen in brain. Science 242: 1444-1446, 1988.
31. Thomas WG and Sernia C. Immunocytochemical localization of angiotensinogen in the rat brain. Neuroscience 25: 319-341, 1988.
32. Thompson MW, Smith SB, and Sigmund CD. Regulation of human renin mRNA expression and protein release in transgenic mice. Hypertension 28: 290-296, 1996.
33. Unger T, Badoer E, Ganten D, Lang RE, and Rettig R. Brain angiotensin: pathways and pharmacology. Circulation 77: 140-154, 1988.
34. Wright JW and Harding JW. Regulatory role of brain angiotensins in the control of physiological and behavioral responses. Brain Res Brain Res Rev 17: 227-262, 1992.
35. Yang G, Gray TS, Sigmund CD, and Cassell MD. The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain Res 817: 123-131, 1999.
36. Yang G, Merrill DC, Thompson MW, Robillard JE, and Sigmund CD. Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem 269: 32497-32502, 1994.
37. Yongue BG, Angulo JA, McEwen BS, and Myers MM. Brain and liver angiotensinogen messenger RNA in genetic hypertensive and normotensive rats. Hypertension 17: 485-491, 1991.