Glucose-insulin-potassium solution improves left ventricular energetics in chronic ovine diabetes

Annals of Thoracic Surgery

Volumn 77, Issue 4, 2004, Pages 1408-1414

  Ramanathan, Tharumenthiran ^a   Morita, Shin ^a   Huang, Yifei ^a   Shirota, Kazuaki ^a   Nishimura, Takashi ^a   Zheng, Xing ^a   Hunyor, Stephen N ^a  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

31

Indexed keywords

FATTY ACID; GLUCOSE; GLUCOSE INSULIN POTASSIUM SOLUTION; INSULIN; POTASSIUM; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENERGY CONSUMPTION; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE PRESSURE; HEART VOLUME; LIPID TRANSPORT; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SHEEP; STREPTOZOCIN DIABETES;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ENERGY METABOLISM; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HEART VENTRICLES; INSULIN; MYOCARDIAL CONTRACTION; OXYGEN CONSUMPTION; POTASSIUM; SHEEP; STROKE VOLUME; VENTRICULAR FUNCTION, LEFT;

EID: 1842584763     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2003.10.016     Document Type: Article

References (28)

1. The BARI Investigators. Influence of diabetes on five-year mortality and morbidity in a randomized trial comparing PTCA and CABG in patients with mulitvessel disease. Circulation. 97:1997;1761-1769.
2. The BARI Investigators. Seven-year outcome in Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status. J Am Coll Cardiol. 35:2000;1122-1129.
3. Thourani V., Weintraub W., Stein B., et al. Influence of diabetes mellitus on early and late outcome after coronary artery bypass grafting. Ann Thorac Surg. 67:1999;1045-1052.
4. Carson J., Scholz P., Chen A., Peterson E., Gold J., Schneider S. Diabetes mellitus increases short-term mortality and morbidity in patients undergoing coronary artery bypass graft surgery. J Am Coll Cardiol. 40:2002;418-423.
5. Paulson D. The diabetic heart is more sensitive to ischemic injury. Cardiovasc Res. 34:1997;104-112.
6. Stanley W., Lopaschuk G., McCormack J. Regulation of energy substrate metabolism in the diabetic heart. Cardiovasc Res. 34:1997;25-33.
7. Ramanathan T., Shirota K., Morita S., et al. Left ventricular oxygen utilization efficiency is impaired in chronic streptozotocin-diabetic sheep. Cardiovasc Res. 55:2002;749-756.
8. Lazar H., Chipkin S., Philippides G., Bao Y., Apstein C. Glucose-insulin-potassium solutions improve outcomes in diabetics who have coronary artery operations. Ann Thorac Surg. 70:2000;145-150.
9. Malmberg K., Ryden L., Hamsten A., et al. Effects of insulin treatment on cause specific 1 year mortality and morbidity in diabetic patients with acute myocardial infarction. Eur Heart J. 17:1996;1337-1344.
10. Korvald C., Elvenes O., Myrmel T. Myocardial substrate metabolism influences left ventricular energetics in vivo. Am J Physiol Heart Circ Physiol. 278:2000;H1345-1351.
11. Ferrannini F., Santoro D., Bonadonna R., et al. Metabolic and hemodynamic effects of insulin on human hearts. Am J Physiol. 267:1993;E308-315.
12. Ramanathan T., Shirota K., Morita S., Nishimura T., Huang Y., Hunyor S. Glucose-insulin-potassium solution improves left ventricular mechanics in diabetes. Ann Thorac Surg. 73:2002;582-587.
13. Suga H. Ventricular energetics. Physiol Rev. 70:1990;247-277.
14. Dickinson J., Meyer B., Chmielowice S., Palmer S. Streptozocin-induced diabetes mellitus in the pregnant-ewe. Am J Obstet Gynecol. 165:1991;1673-1677.
15. Rogers W., Stanley A., Breinig J., et al. Reduction of hospital mortality rate of acute myocardial infarction with glucose-insulin-potassium infusion. Am Heart J. 92:1976;441-454.
16. Fath-Ordoubadi F., Beatt K. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction an overview of randomized placebo-controlled trials. Circulation. 96:1997;1152-1156.
17. Diaz R., Paolasso E., Piegas L., et al. Metabolic modulation of acute myocardial infarction The ECLA glucose-insulin-potassium pilot trial. Circulation. 98:1998;2227-2234.
18. Furukawa S., Bavaria J., Kreiner G., Edmunds L. Relationship between total mechanical energy and oxygen consumption in the stunned myocardium. Ann Thorac Surg. 49:1990;543-549.
19. Suga H., Hisano R., Goto Y., Yamada O., Igarashi Y. Effect of positive inotropic agents on the relation between oxygen consumption and systolic pressure-volume area in canine left ventricle. Circ Res. 53:1983;306-318.
20. Sunagawa K., Maughan W., Burkhoff D., Sagawa K. Left ventricular interaction with arterial load studied in isolated canine heart. Am J Physiol. 245:1983;H773-780.
21. Opie L. The Heart, physiology, metabolism, pharmacology and therapy. 1984;Grune & Stratton, London.
22. Lopaschuk G., Belke D., Gamble J., et al. Regulation of fatty acid oxidation in the mammalian heart in health and disease. Biochim Biophys Acta. 1213:1994;263-276.
23. Lopaschuk G., Rebeyka I., Allard M. Metabolic modulation a means to mend a broken heart. Circulation. 105:2002;140-142.
24. 2+ cycling in isolated failing human myocardium. Circulation. 105:2002;194-199.
25. 2+ stimulated adenosine triphosphate by insulin. J Pharmacol Exp Ther. 249:1989;623-630.
26. Oliver M., Opie L. Effects of glucose and fatty acids on myocardial ischemia and arrhythmias. Lancet. 343:1994;155-158.
27. Tune J., Mallet R., Downey H. Insulin improves cardiac contractile function and oxygen utilization efficiency during moderate ischemia without compromising myocardial energetics. J Mol Cell Cardiol. 30:1998;2025-2035.
28. Gilbert N., Meyer P., Tauriainen P., et al. Effects of hypothermia on myocardial substrate selection. Ann Thorac Surg. 74:2002;1208-1212.