Cortisol abnormality as a cause of elevated estrogen and immune destabilization: Insights for human medicine from a veterinary perspective

Medical Hypotheses

Volumn 62, Issue 4, 2004, Pages 575-581

  Plechner, Alfred J ^a  

^a California Animals Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN; HYDROCORTISONE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIOTHYRONINE; THYROXINE;

ALLERGY; AUTOIMMUNITY; B LYMPHOCYTE; CANCER; FEEDBACK SYSTEM; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNE SYSTEM; NONHUMAN; OVARY FUNCTION; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; VETERINARY MEDICINE;

CANIS FAMILIARIS; FELIS CATUS;

EID: 1842577747     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2003.12.005     Document Type: Article

References (33)

1. Munck A, Naray-Fejes-Toth A. Glucocorticoid action. In: DeGroot L, editor. Endocrinology. 3rd ed. Philadelphia: W.B. Saunders Co; 1995. p. 1642-54.
2. Parker LN. Adrenal androgens. In: DeGroot L, editor. Endocrinology. 3rd ed. Philadelphia: W.B. Saunders Co; 1995. p. 1836-47.
3. Adams JB. Control of secretion and the function of C19-delta 5-steroids of the human adrenal gland. Mol Cell Endocrinol 1985;41:1-17.
4. Alesci S, Koch CA, Bornstein SR, Pacak K. Adrenal androgens regulation and adrenopause. Endocr Regulat 2001;35:95-100.
5. Lemonick MD. A terrible beauty: an obsessive focus on show-ring looks is crippling, sometimes fatally, America's purebred dogs. Time 1994;65.
6. Plechner AJ, Shannon M. Canine immune complex diseases. Mod Vet Pract 1976;917.
7. Harvey PW. The adrenal in toxicology: target organ and modulator of toxicity. Bristol, PA: Taylor & Francis; 1996. p. 7.
8. Symington T. Functional pathology of the human adrenal gland. Edinburgh: E & S. Livingstone; 1969. p. 63-8.
9. Roberts E. The importance of being dehydroepiandosterone sulfate (in the blood of primates): a longer and healthier life? Biochem Pharmacol 1999;57:329-46.
10. Cutolo M, Seriolo B, Villaggio B, Pizzorni C, Craviotto C, Sulli A. Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis. Ann NY Acad Sci 2002;966:131-42.
11. Cid M, Schnaper HW, Kleinman H. Estrogens and the vascular endothelium. Ann NY Acad Sci 2002;966:143-57.
12. Gell JS, Oh J, Rainey WE, Carr BR. Effect of estradiol on DHEAS production in the human adrenocortical cell line, H295R. J Soc Gynecol Invest 1998;5:144-8.
13. Arafah BM. Increased need for thyroxine in women with hypothyroidism during estrogen therapy. N Engl J Med 2001;344(23):1743-9.
14. Gross HA, Appleman MD, Nicoloff JT. Effect of biologically active steroids on thyroid function in man. J Clin Endocrinol Metab 1971;33:242-8.
15. Jefferies WMcK. In: Safe uses of cortisol, vol. 160. Springfield: Charles C. Thomas Publisher; 1996. p. 181.
16. Jefferies WMcK. In: Safe uses of cortisol. vol. 160. Springfield: Charles C. Thomas Publisher; 1996. p. 106.
17. Orth DN, Kovacs WJ. The adrenal cortex. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, editors. Williams textbook of endocrinology. 9th ed. Philadelphia: W.B. Saunders Co; 1998. p. 545.
18. Gruber CJ, Tschugguel W, Schneeberger C, Huber JC. Production and actions of estrogens. N Engl J Med 2002;346(5):340-52.
19. Lahita RG. The connective tissue diseases and the overall influence of gender. Int J Fertil Menopausal Stud (now Int J Fertil Women's Med) 1996;41(2):156-65.
20. Finkelstein J, Susman EJ, Chinchilli VM, et al. Estrogen or testosterone increases self-reported aggressive behaviors in hypogonadal adolescents. J Clin Endocrinol Metab 1997;82(8):2433-8.
21. Jefferies WMcK. In: Safe uses of cortisol. vol. 91-113. Springfield: Charles C. Thomas Publisher, 1996. p. 163-6.
22. Hickling P, Jacoby RK, Kirwan JR. Joint destruction after glucocorticoids are withdrawn in early rheumatoid arthritis. Brit J Rheumatol 1998;37:930-6.
23. Cutolo M, Sulli A, Pizzorni C, et al. Cortisol, dehydroepiandrosterone sulfate, and androstenedione levels in patients with polymyalgia rheumatica during 12 months of glucocorticoid therapy. Ann NY Acad Sci 2002;966:91-6.
24. Klaitman V, Almog Y. Corticosteroids in sepsis: A new concept for an old drug. Isr Med Assoc J 2003;5(1):51-4.
25. Labrie F, Belanger A, Simard J, Van L, Labrie C. DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Front Neuroendocrinol 2001;22(3):185-212.
26. Spratt DI, Longcope C, Cox PM, Bigos ST, Wilbur-Welling C. Differential changes in serum concentrations of androgens and estrogens (in relation with cortisol) in postmenopausal women with acute illness. J Clin Endocrinol Metabol 1993;76(6):1542-7.
27. Personal communication with David Brownstein, M.D., West Bloomfield, Michigan.
28. Wright JV, Schliesman B, Robinson L. Comparative measurements of serum estriol, estradiol, and estrone in non-pregnant, premenopausal women: A preliminary investigation. Alternat Med Rev 1999;4(4):266-70.
29. Ahmed SA. The immune system as a potential target for environmental estrogens: a new emerging field. Toxicology 2000;7(150):191-206.
30. Mesiano S, Katz SL, Lee JY, Jaffe RB. Phytoestrogens alter adrenocortical function: genistein and daidzein suppress glucocorticoid and stimulate androgen production by cultured adrenal cortical cells. J Clin Endocrinol Metab 1999;84(7):2443-8.
31. Gunin AG, Sharov AA. Proliferation, mitosis orientation, and morphogenetic changes in the uterus of mice following chronic treatment with both estrogen and glucocorticoid hormones. J Endocrinol 2001;169:23-31.
32. Jefferies WMcK. In: Safe uses of cortisol. vol. 160. Springfield: Charles C. Thomas Publisher; 1996. p. 67-90.
33. Cutolo M, Bulsma WJ, Lahita RG, Masi AT, Straub RH, Bradlow HL. Altered neuroendocrine immune (NEI) networks in rheumatology. Ann NY Acad Sci 2002;966:xvii.