Stress Proteins as Molecular Markers of Neurotoxicity

Toxicologic Pathology

Volumn 28, Issue 1, 2000, Pages 105-112

  Rajdev, Sunita ^a   Sharp, Frank R ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Heat shock; hsp70; ischemia; neuroprotection; stress response

Indexed keywords

BIOLOGICAL MARKER; DIZOCILPINE; HEAT SHOCK PROTEIN 70; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; PHENCYCLIDINE;

ANIMAL CELL; BRAIN ISCHEMIA; CONFERENCE PAPER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE; SPINAL CORD INJURY; STIMULUS RESPONSE; SUBARACHNOID HEMORRHAGE;

ANIMALS; BIOLOGICAL MARKERS; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; NEUROTOXICITY SYNDROMES;

ANIMALIA; EUKARYOTA;

EID: 0033976019     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262330002800113     Document Type: Article

References (68)

1. Andreasen NC (1997). The role of the thalamus in schizophrenia. Can J Psychiatr 42: 27-33.
2. Arnold J., Dawson S., Fergusson J., Lowe J., Landon M., Mayer RJ (1998). Ubiquitin and its role in neurodegeneration. Prog Brain Res 117: 23-34.
3. Barbe MF, Tytell M., Gower DJ, Welch WJ (1988). Hyperthermia protects against light damage in the rat retina. Science 241: 1817-1820.
4. Benjamin IJ, McMillan DR (1998). Stress (heat shock) proteins: Molecular chaperones in cardiovascular biology and disease. Circ Res 83: 117-132.
5. Blennow K., Davidsson P., Gottfries CG, Ekman R., Heilig M. (1996). Synaptic degeneration in thalamus in schizophrenia [letter]. Lancet 348: 692-693.
6. Brown IR (1983). Hyperthermia induces the synthesis of a heat shock protein by polysomes isolated from the fetal and neonatal mammalian brain. J Neurochem 40: 1490-1493.
7. Chen J., Graham SH, Zhu RL, Simon RP (1996). Stress proteins and tolerance to focal cerebral ischemia. J Cereb Blood Flow Metab 16: 566-577.
8. Chopp M., Chen H., Ho KL, Dereski MO, Brown E., Hetzel FW, Welch KM (1989). Transient hyperthermia protects against subsequent forebrain ischemic cell damage in the rat. Neurology 39: 1396-1398.
9. Cosgrove JW, Brown IR (1983). Heat shock protein in mammalian brain and other organs after a physiologically relevant increase in body temperature induced by D-lysergic acid diethylamide. Proc Natl Acad Sci USA 80: 569-573.
10. Currie RW, White FP (1983). Characterization of the synthesis and accumulation of a 71-kilodalton protein induced in rat tissues after hyperthermia. Can J Biochem Cell Biol 61: 438-446.
11. Dutcher SA, Underwood BD, Walker PD, Diaz FG, Michael DB (1998). Patterns of heat-shock protein 70 biosynthesis following human traumatic brain injury. J Neurotrauma 15: 411-420.
12. Ferriero DM, Soberano HQ, Simon RP, Sharp FR (1990). Hypoxia-ischemia induces heat shock protein-like (HSP72) immunoreactivity in neonatal rat brain. Brain Res Dev Brain Res 53: 145-150.
13. Freedman MS, Clark BD, Cruz TF, Gurd JW, Brown IR (1981). Selective effects of LSD and hyperthermia on the synthesis of synaptic proteins and glycoproteins. Brain Res 207: 129-145.
14. Freyaldenhoven TE, Ali SF (1997). Role of heat shock proteins in MPTP-induced neurotoxicity. Ann NY Acad Sci 825: 167-178.
15. Glazier SS, O'Rourke DM, Graham DI, Welsh FA (1994). Induction of ischemic tolerance following brief focal ischemia in rat brain. J Cereb Blood Flow Metab 14: 545-553.
16. Gonzalez MF, Lowenstein D., Fernyak S., Hisanaga K., Simon R., Sharp FR (1991). Induction of heat shock protein 72-like immunoreactivity in the hippocampal formation following transient global ischemia. Brain Res Bull 26: 241-250.
17. Gonzalez MF, Shiraishi K., Hisanaga K., Sagar SM, Mandabach M., Sharp FR (1989). Heat shock proteins as markers of neural injury. Brain Res Mol Brain Res 6: 93-100.
18. Gower DJ, Hollman C., Lee KS, Tytell M. (1989). Spinal cord injury and the stress protein response. J Neurosurg 70: 605-611.
19. Harrison PJ, Procter AW, Exworthy T., Roberts GW, Najlerahim A., Barton AJ, Pearson RC (1993). Heat shock protein (hsp70) mRNA expression in human brain: Effects of neurodegenerative disease and agonal state. Neuropathol Appl Neurobiol 19: 10-21.
20. Kato H., Liu Y., Kogure K., Kato K. (1994). Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance. Brain Res 634: 235-244.
21. Kiang JG, Tsokos GC (1998). Heat shock protein 70 kDa: Molecular biology, biochemistry, and physiology. Pharmacol Ther 80: 183-201.
22. Kinouchi H., Sharp FR, Hill MP, Koistinaho J., Sagar SM, Chan PH (1993). Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 13: 105-115.
23. Kinouchi H., Sharp FR, Koistinaho J., Hicks K., Kamii H., Chan PH (1993). Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra’ following focal cerebral ischemia in the rat. Brain Res 619: 334-338.
24. Kirino T., Tsujita Y., Tamura A. (1991). Induced tolerance to ischemia in gerbil hippocampal neurons. J Cereb Blood Flow Metab 11: 299-307.
25. Kitagawa K., Matsumoto M., Kuwabara K., Tagaya M., Ohtsuki T., Hata R., Ueda H., Handa N., Kimura K., Kamada T. (1991). Ischemic tolerance phenomenon detected in various brain regions. Brain Res 561: 203-211.
26. Landry J., Huot J. (1999). Regulation of actin dynamics by stress-activated protein kinase 2 (SAPK2)-dependent phosphorylation of heat-shock protein of 27 kDa (Hsp27). Biochem Soc Symp 64: 79-89.
27. Li GC, Li L., Liu YK, Mak JY, Chen L., Lee Wmf (1991) Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene. Proc Natl Acad Sci USA 88: 1681-1685.
28. Li Y., Chopp M., Yoshida Y., Levine SR (1992). Distribution of 72-kDa heat-shock protein in rat brain after hyperthermia. Acta Neuropathol Berl 84: 94-99.
29. Liu Y., Kato H., Nakata N., Kogure K. (1993). Temporal profile of heat shock protein 70 synthesis in ischemic tolerance induced by preconditioning ischemia in rat hippocampus. Neuroscience 56: 921-927.
30. Lowenstein DH, Simon RP, Sharp FR (1990). The pattern of 72-kDa heat shock protein-like immunoreactivity in the rat brain following fluothyl-induced status epilepticus. Brain Res 531: 173-182.
31. Maines MD (1997). The heme oxygenase system: A regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517-554.
32. Marber MS, Mestril R., Chi SH, Sayen MR, Yellon DM, Dillmann WH (1995). Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest 95: 1446-1456.
33. Massa SM, Swanson RA, Sharp FR (1996). The stress gene response in brain. Cerebrovasc Brain Metab Rev 8: 95-158.
34. Matz PG, Weinstein PR, Sharp FR (1997). Heme oxygenase-1 and heat shock protein 70 induction in glia and neurons throughout rat after experimental intracerebral hemorrhage. Neurosurgery 40: 152-160.
35. Matz P., Weinstein P., States B., Honkaniemi J., Sharp FR (1996). Subarachnoid injections of lysed blood induce the hsp70 stress gene and produce DNA fragmentation in focal areas of the rat brain. Stroke 27: 504-512.
36. Mayer RJ, Brown IR (1994). Heat Shock Proteins in the Nervous System. Academic Press, San Diego.
37. Morimoto RI, Santoro MG (1998). Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection. Nat Biotechnol 16: 833-838.
38. Morimoto RI, Tissières A, Georgooulos G (eds) (1994). The Biology of Heat Shock Proteins and Molecular Chaperones. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
39. Nagata K., Hosokawa N. (1996). Regulation and function of collagen-specific molecular chaperone, HSP47. Cell Struct Funct 21: 425-430.
40. Nakata N., Kato H., Kogure K. (1993). Inhibition of ischaemic tolerance in the gerbil hippocampus by quercetin and anti-heat shock protein-70 antibody. NeuroReport 4: 695-698.
41. Nakki R., Koistinaho J., Sharp FR, Sagar SM (1995). Cerebellar toxicity of phencyclidine. J Neurosci 15: 2097-2108.
42. Nowak TS Jr (1985). Synthesis of a stress protein following transient ischemia in the gerbil. J Neurochem 45: 1635-1641.
43. Nowak TS Jr (1988). Effects of amphetamine on protein synthesis and energy metabolism in mouse brain: Role of drug-induced hyperthermia. J Neurochem 50: 285-294.
44. Olney JW, Labruyere J., Price MT (1989) Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244: 1360-1362.
45. Plumier JC, Krueger AM, Currie RW, Kontoyiannis D., Kollias G., Pagoulatos GN (1997). Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury. Cell Stress Chaperones 2: 162-167.
46. Plumier JC, Ross BM, Currie RW, Angelidis CE, Kazlaris H., Kollias G., Pagoulatos GN (1995). Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery. J Clin Invest 95: 1854-1860.
47. Pratt WB (1998). The hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors. Proc Soc Exp Biol Med 217: 420-434.
48. Radford NB, Fina M., Benjamin IJ, Moreadith RW, Graves KH, Zhao P., Gavva S., Wiethoff A., Sherry AD, Malloy CR, Williams RS (1996). Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proc Natl Acad Sci USA 93: 2339-2342.
49. Rajdev S., Fix AS, Sharp FR (1998). Acute phencyclidine neurotoxicity in rat forebrain: Induction of haem oxygenase-1 and attenuation by the antioxidant dimethylthiourea. Eur J Neurosci 10: 3840-3852.
50. Rajdev S., Hara K., Yasuaki M., Solway KE, Mestril R., Dillmann WH, Weinstein PR, Sharp FR (1999). Overexpression of heat shock protein 70 in transgenic mice confers protection against cerebral ischemic injury in vivo. Stroke 30: 274 (abstract).
51. Riabowol KT, Mizzen LA, Welch WJ (1988). Heat shock is lethal to fibroblasts microinjected with antibodies against hsp70. Science 242: 433-436.
52. Ritossa F. (1996). Discovery of the heat shock response. Cell Stress Chaperones 1: 97-98.
53. Sakurai M., Aoki M., Abe K., Sadahiro M., Tabayashi K. (1998). Selective motor neuron death and heat shock protein induction after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 113: 159-164.
54. Sakurai M., Hayashi T., Abe K., Aoki M., Sadahiro M., Tabayashi K. (1998). Enhancement of heat shock protein expression after transient ischemia in the preconditioned spinal cord of rabbits. J Vasc Surg 27: 720-725.
55. Sharp FR, Butman M., Koistinaho J., Aardalen K., Nakki R., Massa SM, Swanson RA, Sagar SM (1994). Phencyclidine induction of the hsp 70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels. Neuroscience 62: 1079-1092.
56. Sharp FR, Butman M., Wang S., Koistinaho J., Graham SH, Sagar SM, Noble L., Berger P., Longo FM (1992). Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine. J Neurosci Res 33: 605-616.
57. Sharp FR, Jasper P., Hall J., Noble L., Sagar SM (1991). MK-801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex. Ann Neurol 30: 801-809.
58. Sharp FR, Lowenstein D., Simon R., Hisanaga K. (1991). Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction. J Cereb Blood Flow Metab 11: 621-627.
59. Sharp FR, Massa SM, Swanson RA (1999). Heat-shock protein protection. Trends Neurosci 22: 97-99.
60. Sharp FR, Sagar SM (1994). Alterations in gene expression as an index of neuronal injury: Heat shock and the immediate early gene response. Neurotoxicology 15: 51-59.
61. Shimosaka S., So YT, Simon RP (1992). Distribution of HSP72 induction and neuronal death following limbic seizures. Neurosci Lett 138: 202-206.
62. States BA, Honkaniemi J., Weinstein PR, Sharp FR (1996). DNA fragmentation and HSP70 protein induction in hippocampus and cortex occurs in separate neurons following permanent middle cerebral artery occlusions. J Cereb Blood Flow Metab 16: 1165-1175.
63. Turner CP, Panter SS, Sharp FR (1999). Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed blood. Brain Res Mol Brain Res 65: 87-102.
64. Vass K., Berger ML, Nowak TS Jr, Welch WJ, Lassmann H. (1989). Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat. Neurosci Lett 100: 259-264.
65. Vass K., Welch WJ, Nowak TS Jr (1988). Localization of 70-kDa stress protein induction in gerbil brain after ischemia. Acta Neuropathol Berl 77: 128-135.
66. Yee WM, Frim DM, Isacson O. (1993). Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex. Exp Brain Res 94: 193-202.
67. Yenari MA, Fink SL, Sun GH, Chang LK, Patel MK, Kunis DM, Onley D., Ho DY, Sapolsky RM, Steinberg GK (1998). Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy. Ann Neurol 44: 584-591.
68. Yenari MA, Lee SJ, Sun GH, Emond MR, Giffard RG, Steinberg GK (1999). Transgenic mice which overexpress hsp70 are protected from some but not all central nervous system insults. Stroke 30: 233 (abstract).