Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies

Nature Genetics

Volumn 28, Issue 4, 2001, Pages 361-364

  Douglas, Julie A ^a,b   Boehnke, Michael ^b   Gillanders, Elizabeth ^c   Trent, Jeffrey M ^c   Gruber, Stephen B ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 2; CHROMOSOME ANALYSIS; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENOTYPE; HAPLOTYPE; HUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT;

ANIMALS; CHROMOSOMES, HUMAN; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENOTYPE; HAPLOTYPES; HUMANS; HYBRID CELLS; IN SITU HYBRIDIZATION, FLUORESCENCE; LINKAGE DISEQUILIBRIUM; MALE; MICE; POLYMERASE CHAIN REACTION;

EID: 0034934775     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng582     Document Type: Article

References (17)

1. Monoallelic mutation analysis (MAMA) for identifying germline mutations
2. Analysis of masked mutations in familial adenomatous polyposis
3. Conversion of diploidy to haploidy
4. Genetic testing - Present and future
5. Estimation of myriad haplotype frequencies
6. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
7. HAPLO: A program using the EM algorithm to estimate the frequencies of multi-site haplotypes
8. An E-M algorithm and testing strategy for multiple-locus haplotypes
9. Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR
10. Loss of information due to ambiguous haplotyping of SNPs
11. Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes
12. The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25
13. The beta-subunit of follicle-stimulating hormone is deleted in patients with aniridia and Wilms' tumour, allowing a further definition of the WAGR locus
14. The accuracy of statistical methods for estimation of haplotype frequencies: An example from the CD4 locus
15. Estimation of linkage disequilibrium in randomly mating populations
16. Efficiency of estimation of haplotype frequencies: Use of marker phenotypes of unrelated individuals versus gene counting of phase known gametes
17. Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping