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Volumn 62, Issue 6 SUPPL. 4, 2004, Pages

Subcutaneously administered apomorphine: Pharmacokinetics and metabolism

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARKINSON AGENT; APOMORPHINE; CATECHOL METHYLTRANSFERASE; DOPAMINE RECEPTOR STIMULATING AGENT;

EID: 1842523189     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.62.6_suppl_4.s8     Document Type: Review
Times cited : (93)

References (38)
  • 1
    • 0033819538 scopus 로고    scopus 로고
    • Apomorphine: An underutilized therapy for Parkinson's disease
    • Poewe W, Wenning, GK. Apomorphine: an underutilized therapy for Parkinson's disease. Mov Disord 2000;15:789-794.
    • (2000) Mov Disord , vol.15 , pp. 789-794
    • Poewe, W.1    Wenning, G.K.2
  • 4
    • 0023858286 scopus 로고
    • Subcutaneous apomorphine in Parkinsonian on-off fluctuations
    • Stibe CM, Kempster PA, Lees AJ, Stern GM. Subcutaneous apomorphine in Parkinsonian on-off fluctuations. Lancet 1988;1:403-406.
    • (1988) Lancet , vol.1 , pp. 403-406
    • Stibe, C.M.1    Kempster, P.A.2    Lees, A.J.3    Stern, G.M.4
  • 5
    • 0021142576 scopus 로고
    • On-off fluctuations in Parkinson's disease: A clinical and neuropharmacological study
    • Hardie RRJ, Lees AJ, Stern GM. On-off fluctuations in Parkinson's disease: a clinical and neuropharmacological study. Brain 1984;107:487-506.
    • (1984) Brain , vol.107 , pp. 487-506
    • Hardie, R.R.J.1    Lees, A.J.2    Stern, G.M.3
  • 6
    • 0012220145 scopus 로고    scopus 로고
    • Extending the action of levodopa's effects
    • LeWitt PA, Oertel WH, eds. London: Martin Dunitz Publishers
    • LeWitt PA. Extending the action of levodopa's effects. In: LeWitt PA, Oertel WH, eds. Parkinson's disease: the treatment options. London: Martin Dunitz Publishers, 1999;141-158.
    • (1999) Parkinson's Disease: The Treatment Options , pp. 141-158
    • LeWitt, P.A.1
  • 7
    • 0031923068 scopus 로고    scopus 로고
    • Continuous subcutaneous waking day apomorphine in the long term treatment of levodopa induced interdose dyskinesias in Parkinson's disease
    • Colzi A, Turner K, Lees AJ. Continuous subcutaneous waking day apomorphine in the long term treatment of levodopa induced interdose dyskinesias in Parkinson's disease. J Neurol Neurosurg Psychiatry 1998;64:573-576.
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , pp. 573-576
    • Colzi, A.1    Turner, K.2    Lees, A.J.3
  • 8
    • 0036869028 scopus 로고    scopus 로고
    • Apomorphine monotherapy in the treatment of refractory motor complications of Parkinson's disease: Long-term follow-up study of 64 patients
    • Manson AJ, Turner K, Lees AJ. Apomorphine monotherapy in the treatment of refractory motor complications of Parkinson's disease: long-term follow-up study of 64 patients. Mov Disord 2002;17:1235-1241.
    • (2002) Mov Disord , vol.17 , pp. 1235-1241
    • Manson, A.J.1    Turner, K.2    Lees, A.J.3
  • 12
    • 0028227163 scopus 로고
    • Clinical usefulness of apomorphine in movement disorders
    • Colosimo C, Merello M, Albanese A. Clinical usefulness of apomorphine in movement disorders. Clin Neuropharmacol 1994;17:243-259.
    • (1994) Clin Neuropharmacol , vol.17 , pp. 243-259
    • Colosimo, C.1    Merello, M.2    Albanese, A.3
  • 13
    • 0034843085 scopus 로고    scopus 로고
    • A randomized double-blind placebo-controlled trial of subcutaneously injected apomorphine for Parkinsonian "off" states
    • Dewey RB, Hutton JT, LeWitt PA, Factor SA. A randomized double-blind placebo-controlled trial of subcutaneously injected apomorphine for Parkinsonian "off" states. Arch Neurol 2001;58:1385-1392.
    • (2001) Arch Neurol , vol.58 , pp. 1385-1392
    • Dewey, R.B.1    Hutton, J.T.2    LeWitt, P.A.3    Factor, S.A.4
  • 14
    • 0002141531 scopus 로고
    • Historical highlights of the chemistry, pharmacology, and early clinical uses of apomorphine
    • Gessa GL, Corsini GU, eds. New York: Raven Press
    • Neumeyer JL, Lal S, Baldessarini RJ. Historical highlights of the chemistry, pharmacology, and early clinical uses of apomorphine. In: Gessa GL, Corsini GU, eds. Apomorphine and other dopaminomimetics. Basic pharmacology. Vol. 1. New York: Raven Press, 1981:1-17.
    • (1981) Apomorphine and Other Dopaminomimetics. Basic Pharmacology , vol.1 , pp. 1-17
    • Neumeyer, J.L.1    Lal, S.2    Baldessarini, R.J.3
  • 16
    • 0021351867 scopus 로고
    • Aporphine enantiomers: Interactions with D1 and D2 dopamine receptors
    • Goldman ME, Kebabian J. Aporphine enantiomers: interactions with D1 and D2 dopamine receptors. Mol Pharmacol 1984;25:18-23.
    • (1984) Mol Pharmacol , vol.25 , pp. 18-23
    • Goldman, M.E.1    Kebabian, J.2
  • 17
    • 0036827811 scopus 로고    scopus 로고
    • Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes
    • Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J Pharmacol Exp Ther 2002;303:791-804.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 791-804
    • Millan, M.J.1    Maiofiss, L.2    Cussac, D.3    Audinot, V.4    Boutin, J.A.5    Newman-Tancredi, A.6
  • 20
    • 0032617670 scopus 로고    scopus 로고
    • Future delivery systems for apomorphine in patients with Parkinson's disease
    • van Laar T, van der Geest R, Danhof M. Future delivery systems for apomorphine in patients with Parkinson's disease. Adv Neurol 1999;80:535-544.
    • (1999) Adv Neurol , vol.80 , pp. 535-544
    • Van Laar, T.1    Van Der Geest, R.2    Danhof, M.3
  • 21
    • 0035125765 scopus 로고    scopus 로고
    • Intravenous apomorphine therapy in Parkinson's disease: Clinical and pharmacokinetic observations
    • Manson AJ, Hanagasi H, Turner K, et al. Intravenous apomorphine therapy in Parkinson's disease: clinical and pharmacokinetic observations. Brain 2001;124:331-340.
    • (2001) Brain , vol.124 , pp. 331-340
    • Manson, A.J.1    Hanagasi, H.2    Turner, K.3
  • 22
    • 18744365480 scopus 로고    scopus 로고
    • Controlled-release transdermal apomorphine treatment for motor fluctuations in Parkinson's disease
    • Priano L, Albani G, Calderoni S, et al. Controlled-release transdermal apomorphine treatment for motor fluctuations in Parkinson's disease. Neurol Sci 2002;23(suppl 2):S99-100.
    • (2002) Neurol Sci , vol.23 , Issue.SUPPL. 2
    • Priano, L.1    Albani, G.2    Calderoni, S.3
  • 23
    • 0031405246 scopus 로고    scopus 로고
    • Iontophoretic delivery of apomorphine. II: An in vivo study in patients with Parkinson's disease
    • van der Geest R, van Laar T, Gubbens-Stibbe JM, Bodde HE, Danhof M. Iontophoretic delivery of apomorphine. II: An in vivo study in patients with Parkinson's disease. Pharmacol Res 1997;14:1804-1810.
    • (1997) Pharmacol Res , vol.14 , pp. 1804-1810
    • Van Der Geest, R.1    Van Laar, T.2    Gubbens-Stibbe, J.M.3    Bodde, H.E.4    Danhof, M.5
  • 24
    • 0031689568 scopus 로고    scopus 로고
    • A double-blind placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease
    • Dewey RB, Marangore DM, Ahlskog JE. A double-blind placebo-controlled study of intranasal apomorphine spray as a rescue agent for off-states in Parkinson's disease. Mov Disord 1998;13:782-787.
    • (1998) Mov Disord , vol.13 , pp. 782-787
    • Dewey, R.B.1    Marangore, D.M.2    Ahlskog, J.E.3
  • 26
  • 27
    • 0032851760 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships of apomorphine in patients with Parkinson's disease
    • Neef C, van Laar T. Pharmacokinetic-pharmacodynamic relationships of apomorphine in patients with Parkinson's disease. Clin Pharmacokinet 1999;37:257-271.
    • (1999) Clin Pharmacokinet , vol.37 , pp. 257-271
    • Neef, C.1    Van Laar, T.2
  • 28
    • 0027537913 scopus 로고
    • Reproducibility of motor effects induced by successive subcutaneous apomorphine injections in Parkinson's disease
    • Gervason CL, Pollak PR, Limousin P, Perret JE. Reproducibility of motor effects induced by successive subcutaneous apomorphine injections in Parkinson's disease. Clin Neuropharmacol 1993;16:113-119.
    • (1993) Clin Neuropharmacol , vol.16 , pp. 113-119
    • Gervason, C.L.1    Pollak, P.R.2    Limousin, P.3    Perret, J.E.4
  • 29
    • 0027440179 scopus 로고
    • A double-blind study of the efficacy of apomorphine and its assessment in "off"-periods in Parkinson's disease
    • van Laar T, Jansen EN, Essink AW, Neef C, Oosterloo S, Roos RA. A double-blind study of the efficacy of apomorphine and its assessment in "off"-periods in Parkinson's disease. Clin Neurol Neurosurg 1993;95:231-235.
    • (1993) Clin Neurol Neurosurg , vol.95 , pp. 231-235
    • Van Laar, T.1    Jansen, E.N.2    Essink, A.W.3    Neef, C.4    Oosterloo, S.5    Roos, R.A.6
  • 30
    • 0027460177 scopus 로고
    • Apomorphine in treatment of Parkinson's disease: Comparison between subcutaneous and sublingual routes
    • Deffond D, Durif F, Tournilhax M. Apomorphine in treatment of Parkinson's disease: comparison between subcutaneous and sublingual routes. J Neurol Neurosurg Psychiatry 1993;56:101-103.
    • (1993) J Neurol Neurosurg Psychiatry , vol.56 , pp. 101-103
    • Deffond, D.1    Durif, F.2    Tournilhax, M.3
  • 31
    • 0031927819 scopus 로고    scopus 로고
    • Dose response and concentration response relationship of patients with Parkinson's disease and end-of-dose akinesia
    • Harder S, Baas H, Demisch L, Simon E. Dose response and concentration response relationship of patients with Parkinson's disease and end-of-dose akinesia. Int J Clin Pharmacol Ther 1998;36:355-362.
    • (1998) Int J Clin Pharmacol Ther , vol.36 , pp. 355-362
    • Harder, S.1    Baas, H.2    Demisch, L.3    Simon, E.4
  • 32
    • 0028053035 scopus 로고
    • Pharmacokinetics of apomorphine in Parkinson's disease: Plasma and cerebrospinal fluid levels in relation to motor responses
    • Hofstee DJ, Neef C, van Laar T, Jansen EN. Pharmacokinetics of apomorphine in Parkinson's disease: plasma and cerebrospinal fluid levels in relation to motor responses. Clin Neuropharmacol 1994;17:45-52.
    • (1994) Clin Neuropharmacol , vol.17 , pp. 45-52
    • Hofstee, D.J.1    Neef, C.2    Van Laar, T.3    Jansen, E.N.4
  • 33
    • 0028798114 scopus 로고
    • Peripheral and central pharmacokinetics of apomorphine and its effect on dopaminergic metabolism in humans
    • Przedborski S, Levivier M, Raftopoulos C, Naini AS, Hildebrand J. Peripheral and central pharmacokinetics of apomorphine and its effect on dopaminergic metabolism in humans. Mov Disord 1995;10:28-36.
    • (1995) Mov Disord , vol.10 , pp. 28-36
    • Przedborski, S.1    Levivier, M.2    Raftopoulos, C.3    Naini, A.S.4    Hildebrand, J.5
  • 34
    • 0025880115 scopus 로고
    • Absorption of apomorphine by several routes in parkinsonism
    • Gancher ST, Nutt JG, Woodward WR. Absorption of apomorphine by several routes in parkinsonism. Mov Disord 1991;6:212-216.
    • (1991) Mov Disord , vol.6 , pp. 212-216
    • Gancher, S.T.1    Nutt, J.G.2    Woodward, W.R.3
  • 35
    • 0029069709 scopus 로고
    • Pen injected apomorphine against off phenomena in late Parkinson's disease: A double-blind, placebo controlled study
    • Østergaard L, Wetdelin L, Odin P, et al. Pen injected apomorphine against off phenomena in late Parkinson's disease: a double-blind, placebo controlled study. J Neurol Neurosurg Psychiatry 1995;59:681-687.
    • (1995) J Neurol Neurosurg Psychiatry , vol.59 , pp. 681-687
    • Østergaard, L.1    Wetdelin, L.2    Odin, P.3
  • 37
    • 0029846578 scopus 로고    scopus 로고
    • A new sublingual formulation of apomorphine in the treatment of patients with Parkinson's disease
    • van Laar T, Neef C, Danhof M, Roon KI, Roos RA. A new sublingual formulation of apomorphine in the treatment of patients with Parkinson's disease. Mov Disord 1996;11:633-638.
    • (1996) Mov Disord , vol.11 , pp. 633-638
    • Van Laar, T.1    Neef, C.2    Danhof, M.3    Roon, K.I.4    Roos, R.A.5
  • 38
    • 0031838998 scopus 로고    scopus 로고
    • Pharmacokinetics, enantiomer interconversion, and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease
    • van der Geest R, van Laar T, Kruger PP, et al. Pharmacokinetics, enantiomer interconversion, and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease. Clin Neuropharmacol 1998;21:159-168.
    • (1998) Clin Neuropharmacol , vol.21 , pp. 159-168
    • Van Der Geest, R.1    Van Laar, T.2    Kruger, P.P.3


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