Repeated clonal relapses in classical Hodgkin's lymphoma and the occurrence of a clonally unrelated diffuse large B cell Non-Hodgkin lymphoma in the same patient

Leukemia and Lymphoma

Volumn 45, Issue 5, 2004, Pages 1065-1069

  Thomas, Roman K ^a   Wickenhauser, Claudia ^a   Kube, Dieter ^b   Tesch, Hans ^a   Diehl, Volker ^a   Wolf, Jürgen ^a   Vockerodt, Martina ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Clonal relapse; Clonal relationship; Hodgkin's lymphoma; Non Hodgkin lymphoma

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; IMMUNOGLOBULIN HEAVY CHAIN; METHOTREXATE; VINCRISTINE;

ADULT; ARTICLE; B CELL LYMPHOMA; CANCER CLASSIFICATION; CANCER RECURRENCE; CANCER STAGING; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DNA EXTRACTION; DNA SEQUENCE; DRUG MEGADOSE; FEMALE; GERMINAL CENTER; HISTOPATHOLOGY; HODGKIN DISEASE; HUMAN; LARGE CELL LYMPHOMA; MOLECULAR CLONING; NONHODGKIN LYMPHOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ADULT; BASE SEQUENCE; CELL LINEAGE; CLONE CELLS; FEMALE; HODGKIN DISEASE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOPHENOTYPING; LYMPH NODES; LYMPHOMA, B-CELL; LYMPHOMA, LARGE-CELL, DIFFUSE; POLYMERASE CHAIN REACTION; RECURRENCE;

EID: 1842502791     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190310001643421     Document Type: Article

References (12)

1. Küppers, R. and Rajewsky, K. (1998) "THe origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease", Annual Review of Immunology, 16, 471-493.
2. Jaffe, E.S., Zarate-Osorno, A. and Medeiros, L.J. (1992) "THe interrelationship of Hodgkin's disease and non-Hodgkin's lymphomas - lessons learned from composite and sequential malignancies", Seminars in Diagnostic Pathology, 9, 297-303.
3. Kerl, K., Girardet, C. and Borisch, B. (1999) "A common B-cell precursor in composite lymphomas", New England Journal of Medicine, 341, 764-765.
4. Vockerodt, M., Soares, M., Kanzler, H., Küppers, R., Kube, D., Hansmann, M.L., et al. (1998) "DEtection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged VH genes in different biopsies in relapsed Hodgkin's disease", Blood, 92, 2899-2907.
5. Küppers, R., Zhao, M., Hansmann, M.L. and Rajewsky, K. (1993) "TRacing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections", EMBO Journal, 12, 4955-4967.
6. Jox, A., Zander, T., Diehl, V. and Wolf, J. (1997) "CLonal relapse in Hodgkin's disease", New England Journal of Medicine, 337, 499.
7. Jox, A., Zander, T., Kornacker, M., Kanzler, H., Kuppers, R., Diehl, V., et al. (1998) "DEtection of identical Hodgkin-Reed Sternberg cell specific immunoglobulin gene rearrangements in a patient with Hodgkin's disease of mixed cellularity subtype at primary diagnosis and in relapse two and a half years later", Annals of Oncology, 9, 283-287.
8. Rajewsky, K. (1996) "CLonal selection and learning in the antibody system", Nature, 381, 751-758.
9. Ohno, T., Smir, B.N., Weisenburger, D.D., Gascoyne, R.D., Hinrichs, S.D. and Chan, W.C. (1998) "ORigin of the Hodgkin/ Reed-Sternberg cells in chronic lymphocytic leukemia with 'Hodgkin's transformation'", Blood, 91, 1757-1761.
10. Bräuninger, A., Hansmann, M.L., Strickler, J.G., Dummer, R., Burg, G., Rajewsky, K., et al. (1999) "IDentification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma", New England Journal of Medicine, 340, 1239-1247.
11. Küppers, R., Sousa, A.B., Baur, A.S., Strickler, J.G., Rajewsky, K. and Hansmann, M.L. (2001) "COmmon germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL", Molecular Medicine, 7, 285-292.
12. Bellan, C., Lazzi, S., Zazzi, M., Lalinga, A.V., Palummo, N., Galieni, P., et al. (2002) "IMmunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: Evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells?", Diagnostic Molecular Pathology, 11, 2-8.