Is there a place for N-acetylcysteine in the treatment of septic shock?

Critical Care

Volumn 8, Issue 2, 2004, Pages 93-95

  Del Sorbo, Lorenzo ^a   Zhang, Haibo ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE;

CLINICAL TRIAL; DRUG DEVELOPMENT; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; LIVER FUNCTION; LIVER PERFUSION; NONHUMAN; NOTE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEPSIS; SEPTIC SHOCK;

ACETYLCYSTEINE; ANTIOXIDANTS; HEMODYNAMIC PROCESSES; HUMANS; LIDOCAINE; LIVER; LIVER CIRCULATION; SHOCK, SEPTIC;

EID: 1842478879     PISSN: 13648535     EISSN: None     Source Type: Journal    
DOI: 10.1186/cc2450     Document Type: Note

References (21)

1. Hein OV, Öhring R, Schilling A, Oellerich M, Armstrong VW, Kox WJ, Spies C: N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report. Crit Care 2003, 8:R66-R71.
2. De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL: Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002, 166:98-104.
3. Ince C, Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999, 27:1369-1377.
4. Buwalda M, Ince C: Opening the microcirculation: can vasodilators be useful in sepsis? Intensive Care Med 2002, 28:1208-1217.
5. 2 supply dependence. J Appl Physiol 1992, 72:1499-1505.
6. Zhang H, De Jongh R, De Backer D, Cherkaoui S, Vray B, Vincent JL: Effects of alpha- and beta-adrenergic stimulation on hepatosplanchnic perfusion and oxygen extraction in endotoxic shock. Crit Care Med 2001, 29:581-588.
7. Riedemann NC, Guo RF, Ward PA: The enigma of sepsis. J Clin Invest 2003, 112:460-467.
8. Zhang H, Slutsky AS, Vincent JL: Oxygen free radicals in ARDS, septic shock and organ dysfunction. Intensive Care Med 2000, 26:474-476.
9. Ritter C, Andrades M, Frota Junior ML, Bonatto F, Pinho RA, Polydoro M, Klamt F, Pinheiro CT, Menna-Barreto SS, Moreira JC, Dal-Pizzol F: Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med 2003, 29:1782-1789.
10. Rodriguez-Gaspar M, Santolaria F, Jarque-Lopez A, Gonzalez-Reimers E, Milena A, de la Vega MJ, Rodriguez-Rodriguez E, Gomez-Sirvent JL: Prognostic value of cytokines in SIRS general medical patients. Cytokine 2001, 15:232-236.
11. Chandel NS, Schumacker PT: Cellular oxygen sensing by mitochondria: old questions, new insight. J Appl Physiol 2000, 88:1880-1889.
12. Kiefer P, Tugtekin I, Wiedeck H, Bracht H, Vogt J, Wachter U, Weiss M, Altin C, Georgieff M, Radermacher P: Hepato-splanchnic metabolic effects of the stable prostacyclin analogue iloprost in patients with septic shock. Intensive Care Med 2001, 27:1179-1186.
13. Lauterbach R, Pawlik D, Kowalczyk D, Ksycinski W, Helwich E, Zembala M: Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial. Crit Care Med 1999, 27:807-814.
14. Dhalla NS, Elmoselhi AB, Hata T, Makino N: Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res 2000, 47:446-456.
15. Zhang H, Spapen H, Nguyen DN, Rogiers P, Bakker J, Vincent JL: Effects of N-acetyl-L-cysteine on regional blood flow during endotoxic shock. Eur Surg Res 1995, 27:292-300.
16. Zhang H, Spapen H, Nguyen DN, Benlabed M, Buurman WA, Vincent JL: Protective effects of N-acetyl-L-cysteine in endotexmia. Am J Physiol 1994, 265:H1746-H1754.
17. Rank N, Michel C, Haertel C, Lenhart A, Welte M, Meier-Hellmann A, Spies C: N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study. Crit Care Med 2000, 28:3799-3807.
18. Spapen H, Zhang H, Demanet C, Vleminckx W, Vincent JL, Huyghens L: Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest 1998, 113:1616-1624.
19. Paterson RL, Galley HF, Webster NR: The effect of N-acetylcysteine on nuclear factor-kappa B activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis. Crit Care Med 2003, 31:2574-2578.
20. Bernard GR, Wheeler AP, Arons MM, Morris PE, Paz HL, Russell JA, Wright PE: A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest 1997, 112:164-172.
21. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodríguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ. The Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001, 344:699-709.