Leukocyte associated Ig-like receptor (LAIR)

Journal of Biological Regulators and Homeostatic Agents

Volumn 17, Issue 4, 2003, Pages 330-333

  Meyaard, Linde ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; COMPLEMENTARY DNA; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOCYTE ASSOCIATED IMMUNOGLOBULIN G LIKE RECEPTOR; MEMBRANE PROTEIN; PERVANADATE; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; B LYMPHOCYTE; CHROMOSOME 19Q; CROSS LINKING; DENDRITIC CELL; GENE LOCATION; HUMAN; IMMUNOCOMPETENT CELL; MOLECULAR CLONING; MONONUCLEAR CELL; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; RNA SPLICING; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; STRUCTURE ANALYSIS; T LYMPHOCYTE;

EID: 1842476075     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH. Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. J Immunol 1999; 162: 5800-4.
2. Xu M, Zhao R, Zhao ZJ. Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. J Biol Chem 2000; 275: 17440-6.
3. Meyaard L, Adema GJ, Chang C, et al. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 1997; 7: 283-90.
4. Barten R, Torkar M, Haude A, Trowsdale J, Wilson MJ. Divergent and convergent evolution of NK-cell receptors. Trends Immunol 2001; 22: 52-7.
5. Martin AM, Kulski JK, Witt C, Pontarotti P, Christiansen FT. Leukocyte Ig-like receptor cluster complex (LRC) in mice and men. Trends Immunol 2002; 23: 81-8.
6. Wende H, Volz A, Ziegler A. Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Immunogenetics 2000; 51: 703-13.
7. Verbrugge A, De Ruiter T, Clevers H, Meyaard L. Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment. Int Immunol 2003; 15: 1349-58.
8. Ravetch JV, Lanier LL. Immune inhibitory receptors. Science 2000; 290: 84-9.
9. Van der Vuurst de Vries A, Clevers H, Logtenberg T, Meyaard L. Leukocyte Associated Ig-like Receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling. Eur J Immunol 1999; 29: 3160-7.
10. Poggi A, Pella N, Morelli L, et al. p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans. Eur J Immunol 1995; 25: 369-76.
11. Poggi A, Tomasello E, Revello V, Nanni L, Costa C, Moretta L. p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR-mediated triggering of T lymphocytes. Int Immunol 1997; 9: 1271-9.
12. Saverino D, Fabbi M, Merlo A, Ravera G, Grossi CE, Ciccone E. Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T cell functions. Hum Immunol 2002; 63: 534-46.
13. Fournier N, Chalus L, Durand I, et al. FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol 2000; 165: 1197-209.
14. Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L. p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor. Eur J Immunol 1998; 28: 2086-91.
15. Poggi A, Pellegatta F, Leone BE, Moretta L, Zocchi MR. Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NFkB nuclear translocation in human myeloid leukemias. Eur J Immmunol 2000; 30: 2751-8.
16. Zocchi MR, Pellegatta F, Pierri I, Gobbi M, Poggi A. Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor-dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Eur J Immmunol 2001; 31: 3667-75.
17. Long EO. Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 1999; 17: 875-04.
18. Blery M, Olcese L, Vivier E. Early signaling via inhibitory and activating NK receptors. Hum Immunol 2000; 61: 51-64.
19. Satish JG, Johnson KG, Fuller KJ, et al. Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor - 1 in human T cells. J Immunol 2001; 166: 1763-70.