Process development of a scaleable route to (2R)-[3-(2-Aminopropyl)-1H- indol-7-yloxy]-N,N-diethylacetamide: A key intermediate for AJ-9677, a potent and selective human and rat β3-adrenergic receptor agonist

Organic Process Research and Development

Volumn 8, Issue 2, 2004, Pages 238-245

  Harada, Hiroshi ^a   Fujii, Akihito ^a   Odai, Osamu ^a   Kato, Shiro ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 AMINOPROPYL) 7 BENZYLOXY 1H INDOLE; 3 (2 AMINOPROPYL) 7 HYDROXY 1H INDOLE; 3 [2 (BUTYLOXYCARBONYLAMINO)PROPYL] 1H INDOLE; 3 ACYLINDOLE; 7 BENZYLOXY 1H INDOLE; [3 (2 AMINOPROPYL) 1H INDOL 7 YLOXY] N,N DIETHYLACETAMIDE; [3 (2 AMINOPROPYL) 1H INDOL 7 YLOXY]ACETIC ACID; ACETAMIDE DERIVATIVE; ACETIC ACID DERIVATIVE; AJ 9677; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BROMINE DERIVATIVE; CARBONYL DERIVATIVE; CHLORIDE; HYDROXYL GROUP; INDOLE DERIVATIVE; METHYLMAGNESIUM BROMIDE; N 9 FLUORENYLMETHYLOXYCARBONYL DEXTRO ALANINE CHLORIDE; NITROGEN DERIVATIVE; OXALIC ACID; REAGENT; SODIUM DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; GRIGNARD REACTION; HYDROGENATION; REACTION ANALYSIS; REDUCTION; STRUCTURE ANALYSIS; TECHNIQUE; TEMPERATURE DEPENDENCE;

EID: 1842473183     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0341869     Document Type: Article

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