Anti-Sa antibodies: Prognostic and pathogenetic significance to rheumatoid arthritis

Arthritis Research and Therapy

Volumn 6, Issue 2, 2004, Pages 86-89

  El Gabalawy, Hani ^a,b   Wilkins, John A ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b John Buhler Research Centre   (Canada)

Author keywords

Anti citrulline antibodies; Anti Sa; Autoantibodies; Prognosis; Rheumatoid arthritis; Synovium

Indexed keywords

ANTIRHEUMATIC AGENT; AUTOANTIBODY; SA ANTIBODY; UNCLASSIFIED DRUG; VIMENTIN;

ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; CHEMICAL MODIFICATION; DISEASE SEVERITY; FEMALE; HUMAN; JOINT DESTRUCTION; MALE; PATHOGENESIS; PROGNOSIS; RHEUMATOID ARTHRITIS; SYNOVIUM;

ANTIBODY SPECIFICITY; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; BIOLOGICAL MARKERS; HUMANS; PROGNOSIS;

EID: 1842450895     PISSN: 14786354     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Vossenaar ER, Deprés N, Lapointe E, van der Heijden A, Lora M, Senshu T, van Venrooij WJ, Ménard HA: Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin. Arthritis Res Ther 2004, 6:R142-R150.
2. Despres N, Boire G, Lopez-Longo FJ, Menard HA: The Sa system: a novel antigen-antibody system specific for rheumatoid arthritis. J Rheumatol 1994, 21:1027-1033.
3. Escalona M, Lopez-Longo FJ, Gonzalez CM, Monteagudo I, Rodriguez-Mahou M, Grau R, Carreno L: Anti-Sa sera from patients with rheumatoid arthritis contain at least 2 different subpopulations of anti-Sa antibodies. J Rheumatol 2002, 29:2053-2060.
4. Hueber W, Hassfeld W, Smolen JS, Steiner G: Sensitivity and specificity of anti-Sa autoantibodies for rheumatoid arthritis. Rheumatology (Oxford) 1999, 38:155-159.
5. Goldbach-Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen JS, Steiner G, Rosen A, Zhang C, Menard HA, Zhou ZJ, Palosuo T, Van Venrooij WJ, Wilder RL, Klippel JH, Schumacher HR Jr, El-Gabalawy HS: Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res 2000, 2:236-243.
6. Hayem G, Chazerain P, Combe B, Elias A, Haim T, Nicaise P, Benali K, Eliaou JF, Kahn MF, Sany J, Meyer O: Anti-Sa antibody is an accurate diagnostic and prognostic marker in adult rheumatoid arthritis. J Rheumatol 1999, 26:7-13.
7. Boire G, Cossette P, de Brum-Fernandes AJ, Liang P, Nyonsenga T, Gingras M, Daniel C, Beauchemin J, Ménard HA: Anti-Sa/citrullinated vimentin antibodies, anti-cyclic citrullinated peptide, and IgM rheumatoid factor (RF) as prognostic markers of disease severity in early polyarthritis patients [abstract]. Arthritis Rheum 2003, 48 Suppl:S666.
8. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ: Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 1998, 101:273-281.
9. Vossenaar ER, van Venrooij WJ: Anti-CCP antibodies, a specific marker for (early) rheumatoid arthritis. Clin Applied Immunol Rev 2004, in press.
10. Foley J, Ley CA, Parysek LM: The structure of the human peripherin gene (PRPH) and identification of potential regulatory elements. Genomics 1994, 22:456-461.
11. Reparon-Schuijt CC, van Esch WJ, van Kooten C, Schellekens GA, de Jong BA, van Venrooij WJ, Breedveld FC, Verweij CL: Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis. Arthritis Rheum 2001, 44:41-47.
12. Masson-Bessiere C, Sebbag M, Durieux JJ, Nogueira L, Vincent C, Girbal-Neuhauser E, Durroux R, Cantagrel A, Serre G: In the rheumatoid pannus, anti-filaggrin autoantibodies; are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum. Clin Exp Immunol 2000, 119:544-552.
13. Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E, Nogueira L, Vincent C, Senshu T, Serre G: The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 2001, 166:4177-4184.
14. El-Gabalawy HS, Hitchon CA, Schumacher HR, Yarboro C, Duray P, Goldbach-Mansky R: Synovial histopathological features and RA autoantibodies predict persistence in patients with synovitis of recent onset [abstract]. Arthritis Rheum 2003, 48 Suppl:S667.
15. Ota F, Maeshima A, Yamashita S, Ikeuchi H, Kaneko Y, Kuroiwa T, Hiromura K, Ueki K, Kojima I, Nojima Y: Activin A induces cell proliferation of fibroblast-like synoviocytes; in rheumatoid arthritis. Arthritis Rheum 2003, 48:2442-2449.
16. Marinova-Mutafchieva L, Taylor P, Funa K, Maini RN, Zvaifler NJ: Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint Arthritis Rheum 2000, 43:2046-2055.
17. Xue C, Takahashi M, Hasunuma T, Aono H, Yamamoto K, Yoshino S, Sumida T, Nishioka K: Characterisation of fibroblast-like cells in pannus lesions of patients with rheumatoid arthritis sharing properties of fibroblasts and chondrocytes. Ann Rheum Dis 1997, 56:262-267.
18. Vossenaar ER, Radstake TR, van der Heijden A, Van Mansum WAM, Dieteren C, de Rooij DJ, Barrera P, Zendman AJW, van Venrooij WJ: Expression and activity of citrullinating PAD enzymes in monocytes and macrophages. Ann Rheum Dis 2004, in press.
19. 2+- dependent deimination-induced disassembly of intermediate filaments involves specific modification of the amino-terminal head domain. J Biol Chem 1989, 264:18119-18127.
20. Baier A, Meineckel I, Gay S, Pap T: Apoptosis in rheumatoid arthritis. Curr Opin Rheumatol 2003, 15:274-279.
21. Matsumoto I, Staub A, Benoist C, Mathis D: Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 1999, 286:1732-1735.
22. Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB: MaAt cells: a cellular link between autoantibodies and inflammatory arthritis. Science 2002, 297:1689-1692.
23. Schaller M, Burton DR, Ditzel HJ: Autoantibodies to GPI in rheumatoid arthritis: Linkage between an animal model and human disease. Nat Immunol 2001, 2:746-753.
24. Matsumoto I, Lee DM, Goldbach-Mansky R, Sumida T, Hitchon CA, Schur PH, Anderson RJ, Coblyn JS, Weinblatt ME, Brenner M, Duclos B, Pasquali JL, El Gabalawy H, Mathis D, Benoist C: Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders. Arthritis Rheum 2003, 48:944-954.
25. Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, Sundin U, van Venrooij WJ: Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003, 48:2741-2749.
26. Lee KH, Chung HS, Kim HS, Oh SH, Ha MK, Baik JH, Lee S, Bang D: Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behcet's disease. Arthritis Rheum 2003, 48:2025-2035.
27. Stempel D, Sandusky H, Lampi K, Cilluffo M, Horwitz J, Braun J, GoodglicI L, Gordon LK: βB1-crystallin: identification of a candidate ciliary body uveitis antigen. Invest Ophthalmol Vis Sci 2003, 44:203-209.