The effect of pranlukast on allergen-induced bone marrow eosinophilopoiesis in subjects with asthma

American Journal of Respiratory and Critical Care Medicine

Volumn 169, Issue 8, 2004, Pages 915-920

  Parameswaran, Krishnan ^b   Watson, Richard ^b   Gauvreau, Gail M ^b   Sehmi, Roma ^b   O'Byrne, Paul M ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b NONE

Author keywords

Allergen; Eosinophil progenitor; Leukotriene receptor antagonist; Sputum eosinophil

Indexed keywords

ALLERGEN; CHEMOKINE RECEPTOR CCR3; CYTOKINE; EOTAXIN; INTERLEUKIN 5; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PLACEBO; PRANLUKAST;

ADULT; AIRWAY; ARTICLE; ASTHMA; BASOPHIL; BONE MARROW CELL; CHEMOTAXIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; EOSINOPHIL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPUTUM; STEM CELL; T LYMPHOCYTE;

EID: 1842450674     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200312-1645oc     Document Type: Article

References (44)

1. Gauvreau GM, Watson RM, O'Byrne PM. Kinetics of allergen-induced airway eosinophilic cytokine production and airway inflammation. Am J Respir Crit Care Med 1999;160:640-647.
2. O'Byrne PM, Dolovich J, Hargreave FE. Late asthmatic response. Am Rev Respir Dis 1987;136:740-756.
3. O'Byrne PM, Inman MD, Parameswaran K. The trials and tribulations of IL-5, eosinophils, and allergic asthma. J Allergy Clin Immunol 2001; 108:503-508.
4. Clutterback EJ, Sanderson CJ. Human eosinophil hematopoiesis studied in vitro by means of murine eosinophil differentiation factor (IL-5): production of functionally active eosinophils from normal human bone marrow. Blood 1988;71:646-651.
5. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med 1996;2:449-456.
6. Kameyoshi Y, Dorschner A, Mallet AI, Christophers E, Schroder JM. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 1992;176:587-592.
7. Denburg JA, Sehmi R, Saito H, Pil-Seob J, Inman MD, O'Byrne PM. Systemic aspects of allergic disease: bone marrow responses. J Allergy Clin Immunol 2000;106:S242-S246.
8. Sehmi R, Woods L, Watson RM, Foley R, Hamid Q, O'Byrne PM, Denburg JA. Allergen-induced increases in IL-5α-subunit expression on bone marrow derived CD34+ cells from asthmatic subjects: a novel marker of progenitor cell commitment towards eosinophil differentiation. J Clin Invest 1997;100:2466-2475.
9. Sehmi R, Howie K, Sutherland DR, Shragge W, O'Byrne PM, Denburg JA. Increased levels of CD34 progenitor cells in atopic subjects. Am J Respir Cell Mol Biol 1996;15:645-654.
10. Wood LJ, Inman MD, Watson RM, Denburg JA, Foley R, O'Byrne PM. Bone marrow inflammatory progenitor cells after allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med 1998;157:99-105.
11. Gauvreau GM, Wood LJ, Sehmi R, Watson RM, Dorman SC, Schleimer RP, Denburg JA, O'Byrne PM. The effects of inhaled budesonide on circulating eosinophil progenitors and their expression of cytokines after allergen challenge in subjects with atopic asthma. Am J Respir Crit Care Med 2000;162:2139-2144.
12. Robinson DS, Damia R, Zeibecoglou K, Molet S, North J, Yamada T, Kay AB, Hamid Q. CD34+/interleukin-5Rα messenger RNA+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitors. Am J Respir Cell Mol Biol 1999;20:9-13.
13. Sehmi R, Dorman S, Baatjes A, Watson R, Foley R, Ying S, Robinson DS, Kay AB, O'Byrne PM, Denburg JA. Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation. Immunology 2003;109:536-546.
14. Gauvreau GM, Parameswaran KN, Watson RM, O'Byrne PM. Inhaled leukotriene E4, but not leukotriene D4, increased airway inflammatory cells in subjects with atopic asthma. Am J Respir Crit Care Med 2001;164:1495-1500.
15. Pizzichini E, Leff JA, Reiss TF, Hendeles L, Boulet LP, Wei LX, Efthimiadis AE, Zhang J, Hargreave FE. Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial. Eur Respir J 1999;14:12-18.
16. Peters-Golden M. Do anti-leukotriene agents inhibit asthmatic inflammation? Clin Exp Allergy 2003;33:721-724.
17. 4 effects on human eosinophil and neutrophil motility in vitro. J Leukoc Biol 1994;55:183-191.
18. Fregonese L, Silvestri M, Sabatini F, Rossi G. Cysteinyl leukotrienes induce human eosinophil locomotion and adhesion molecule expression via a Cys-LT1 receptor-mediated mechanism. Clin Exp Allergy 2002;32:745-750.
19. Lee E, Roberston T, Smith J, Kilfeather S. Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals. Am J Respir Crit Care Med 2000;161:1881-1886.
20. Peters-Golden M, Sampson A. Cysteinyl leukotriene interactions with other mediators and with glucocorticoids during airway inflammation. J Allergy Clin Immunol 2003;111:S37-S48.
21. Braccioni F, Dorman SC, O'Byrne PM, Inman MD, Denburg JA, Parameswaran K, Baatjes AJ, Foley R, Gauvreau GM. The effect of cysteinyl leukotrienes on the growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. J Allergy Clin Immunol 2002;110:96-101.
22. Parameswaran K, Watson R, Rerecich T, Otis J, Strinich T, O'Byrne PM. The CysLT1 receptor antagonist, pranlukast, attenuates allergen-induced increase in airway eosinophils and bone marrow derived eosinophil/basophil progenitors in subjects with atopic asthma [abstract]. Eur Respir J 2003;22:349s.
23. American Thoracic Society. Standardization of spirometry, 1994 update. Am J Respir Crit Care Med 1995;152:1107-1136.
24. Cockcroft DW, Murdock KY, Kirby J, Hargreave FE. Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. Am Rev Respir Dis 1987;135:264-267.
25. Pizzichini E, Pizzichini MMM, Efthimiadis A, Hargreave FE, Dolovich J. Measurement of inflammatory indices in induced sputum: effects of selection of sputum to minimize salivary contamination. Eur Respir J 1996;9:1174-1180.
26. Obase Y, Shimoda T, Tomari SY, Mitsuta K, Kawano T, Matsuse H, Kohno S. Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. Chest 2002;121:143-150.
27. Leigh R, Vethanayagam D, Yoshida M, Watson RM, Rerecich T, Inman MD, O'Byrne PM. Effects of montelukast and budesonide on airway responses and airway inflammation in asthma. Am J Respir Crit Care Med 2002;166:1212-1217.
28. Calhoun WJ, Lavins BJ, Minkwitz MC, Evans R, Gleich GJ, Cohn J. Effect of zafirlukast (Accolate) on cellular mediators of inflammation: bronchoalveolar lavage fluid findings after segmental antigen challenge. Am J Respir Crit Care Med 1998;157:1381-1389.
29. Macfarlane AJ, Dworski R, Sheller JR, Pavord ID, Kay AB, Barnes NC. Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. Am J Respir Crit Care Med 2000;161: 1553-1558.
30. Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP, et al. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. Am J Respir Crit Care Med 2001;163:226-233.
31. Bautz F, Denzlinger C, Kanz L, Mohle R. Chemotaxis and transendothelial migration of CD34+ hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1. Blood 2001;97:3433-3440.
32. Underwood DC, Osborn RR, Newsholme SJ, Torphy TJ, Hay DW. Persistent airway eosinophilia after leukotriene D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. Am J Respir Crit Care Med 1996;154:850-857.
33. Adachi T, Alam R. The mechanism of IL-5 signal transduction. Am J Physiol Cell Physiol 1998;44:C623-C633.
34. Elias JA, Lee CG, Zheng T, Shim Y, Zhu Z. Interleukin-13 and leukotrienes: an intersection of the pathogenetic schema. Am J Respir Cell Mol Biol 2003;28:401-404.
35. Thivierge M, Doty M, Johnson J, Stankova J, Pleszczynski MR. IL-5 up-regulates cysteinyl leukotriene 1 receptor expression in HL-60 cells differentiated into eosinophils. J Immunol 2000;165:5221-5226.
36. Palframan RT, Collins PD, Williams TJ, Rankin SM. Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow. Blood 1998;91:2240-2248.
37. Tiffany HL, Alkhatib G, Combadiere C, Berger EA, Murphy PM. CC chemokine receptors 1 and 3 are differentially regulated by IL-5 during maturation of eosinophilic HL-60 cells. J Immunol 1998;160:1385-1392.
38. Wu AY, Chik SC, Chan AW, Li Z, Tsang KW, Li W. Anti-inflammatory effects of high-dose montelukast in an animal model of acute asthma. Clin Exp Allergy 2003;33:359-366.
39. Eum S-Y, Maghni K, Hamid Q, Campbell H, Eidelman DH, Martin JG. Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouse. Am J Respir Cell Mol Biol 2003;28:25-32.
40. Wood LJ, Sehmi R, Dorman S, Hamid Q, Tulic MK, Watson RM, Foley R, Wasi P, Denburg JA, Gauvreau G, et al. Allergen-induced increases in bone marrow T lymphocytes and interleukin-5 expression in subjects with asthma. Am J Respir Crit Care Med 2002;166:883-889.
41. Wood LJ, Sehmi R, Gauvreau GM, Watson RM, Foley R, Denburg JA, O'Byrne PM. An inhaled corticosteroid, budesonide, reduces baseline but not allergen-induced increases in bone marrow inflammatory cell progenitors in asthmatic subjects. Am J Respir Crit Care Med 1999;159:1457-1463.
42. Lindgren JA, Stenke L, Mansour M, Edenius C, Lauren L, Nasman-Glaser B, Ericsson I, Reizenstein P. Formation and effects of leukotrienes and lipoxins in human bone marrow. J Lipid Mediat 1993;6:313-320.
43. Hojo M, Suzuki M, Maghni K, Hamid Q, Powell WS, Martin JG. Role of cysteinyl leukotrienes in CD4(+) T cell-driven late allergic airway responses. J Pharmacol Exp Ther 2000;293:410-416.
44. Kawano T, Matsuse H, Kondo Y, Machida I, Saeki S, Tomari S, Mitsuta K, Obase Y, Fukushima C, Shimoda T, et al. Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma. J Allergy Clin Immunol 2003;112:369-374.