Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy)

Neurobiology of Disease

Volumn 15, Issue 3, 2004, Pages 630-639

  Stefanova, N ^a   Lundblad, M ^b   Tison, F ^c   Poewe, W ^a   Cenci, M A ^b   Wenning, G K ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b LUND UNIVERSITY   (Sweden)

^c CNRS   (France)

Author keywords

Dyskinesia; FosB; Levodopa; Motor improvement; MSA; Rat model

Indexed keywords

LEVODOPA;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; INTERMETHOD COMPARISON; LOW DRUG DOSE; MALE; NEUROPATHOLOGY; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; PULSATILE DRUG RELEASE; RAT; SHY DRAGER SYNDROME; STRIATONIGRAL DEGENERATION; UPREGULATION;

ANIMALS; ANTIPARKINSON AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DYSKINESIAS; FORELIMB; IMAGE PROCESSING, COMPUTER-ASSISTED; LEVODOPA; MALE; MOVEMENT DISORDERS; PARKINSON DISEASE; RATS; STRIATONIGRAL DEGENERATION;

EID: 1842419375     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2003.11.025     Document Type: Article

References (36)

1. Andersson M., Hilbertson A., Cenci M.A. Striatal fosB expression is causally linked with L-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a rat model of Parkinson's disease. Neurobiol. Dis. 6:1999;461-474.
2. Araujo D.M., Cherry S.R., Tatsukawa K.J., Toyokuni T., Kornblum H.I. Deficits in striatal dopamine D(2) receptors and energy metabolism detected by in vivo microPET imaging in a rat model of Huntington's disease. Exp. Neurol. 166:2000;287-297.
3. Barker R., Dunnett S.B. Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat. Exp. Brain Res. 101:1994;365-374.
4. Blanchet P.J., Allard P., Gregoire L., Tardif F., Bedard P.J. Risk factors for peak dose dyskinesia in 100 levodopa-treated parkinsonian patients. Can. J. Neurol. Sci. 23:1996;189-193.
5. Boesch S.M., Wenning G.K., Ransmayr G., Poewe W. Dystonia in multiple system atrophy. J. Neurol., Neurosurg. Psychiatry. 72:2002;300-303.
6. Bradbury J. Are dyskinesias a problem after neural transplantation for Parkinson's disease? Lancet. 359:2002;2007.
7. Calon F., Grondin R., Morissette M., Goulet M., Blanchet P.J., Di Paolo T., Bedard P.J. Molecular basis of levodopa-induced dyskinesias. Ann. Neurol. 47(Suppl. 1):2000;S70-S78.
8. Cenci M.A., Lee C.S., Bjorklund A. L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA. Eur. J. Neurosci. 10:1998;2694-2706.
9. Cenci M.A., Tranberg A., Andersson M., Hilbertson A. Changes in the regional and compartmental distribution of FosB- and JunB-like immunoreactivity induced in the dopamine-denervated rat striatum by acute or chronic L-dopa treatment. Neuroscience. 94:1999;515-527.
10. Cenci M.A., Whishaw I.Q., Schallert T. Animal models of neurological deficits: how relevant is the rat? Nat. Rev., Neurosci. 3:2002;574-579.
11. Dickson D.W., Lin W., Liu W.K., Yen S.H. Multiple system atrophy: a sporadic synucleinopathy. Brain Pathol. 9:1999;721-732.
12. Ghorayeb I., Fernagut P.O., Aubert I., Bezard E., Poewe W., Wenning G.K., Tison F. Toward a primate model of L-dopa-unresponsive parkinsonism mimicking striatonigral degeneration. Mov. Disord. 15:2000;531-536.
13. Ghorayeb I., Puschban Z., Fernagut P.O., Scherfler C., Rouland R., Wenning G.K., Tison F. Simultaneous intrastriatal 6-hydroxydopamine and quinolinic acid injection: a model of early-stage striatonigral degeneration. Exp. Neurol. 167:2001;133-147.
14. Hagell P., Piccini P., Bjorklund A., Brundin P., Rehncrona S., Widner H., Crabb L., Pavese N., Oertel W.H., Quinn N., Brooks D.J., Lindvall O. Dyskinesias following neural transplantation in Parkinson's disease. Nat. Neurosci. 5:2002;627-628.
15. Hughes A.J., Colosimo C., Kleedorfer B., Daniel S.E., Lees A.J. The dopaminergic response in multiple system atrophy. J. Neurol., Neurosurg. Psychiatry. 55:1992;1009-1013.
16. Johansson P.A., Andersson M., Andersson K.E., Cenci M.A. Alterations in cortical and basal ganglia levels of opioid receptor binding in a rat model of L-DOPA-induced dyskinesia. Neurobiol. Dis. 8:2001;220-239.
17. Lee C.S., Cenci M.A., Schulzer M., Bjorklund A. Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease. Brain. 123:2000;1365-1379.
18. Lundblad M., Andersson M., Winkler C., Kirik D., Wierup N., Cenci M.A. Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease. Eur. J. Neurosci. 15:2002;120-132.
19. Mouradian M.M., Heuser I.J., Baronti F., Fabbrini G., Juncos J.L., Chase T.N. Pathogenesis of dyskinesias in Parkinson's disease. Ann. Neurol. 25:1989;523-526.
20. Nakao N., Brundin P. Effects of alpha-phenyl-tert-butyl nitrone on neuronal survival and motor function following intrastriatal injections of quinolinate or 3-nitropropionic acid. Neuroscience. 76:1997;749-761.
21. Pundt L.L., Narang N., Kondoh T., Low W.C. Localization of dopamine receptors and associated mRNA in transplants of human fetal striatal tissue in rodents with experimental Huntington's disease. Neurosci. Res. 27:1997;305-315.
22. Puschban Z., Scherfler C., Granata R., Laboyrie P., Quinn N.P., Jenner P., Poewe W., Wenning G.K. Autoradiographic study of striatal dopamine re-uptake sites and dopamine D1 and D2 receptors in a 6-hydroxydopamine and quinolinic acid double-lesion rat model of striatonigral degeneration (multiple system atrophy) and effects of embryonic ventral mesencephalic, striatal or co-grafts. Neuroscience. 95:2000;377-388.
23. Quinn N.P., Marsden C.D. The motor disorder of multiple system atrophy. J. Neurol., Neurosurg. Psychiatry. 56:1993;1239-1242.
24. Schallert T., Fleming S.M., Leasure J.L., Tillerson J.L., Bland S.T. CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology. 39:2000;777-787.
25. Scherfler C., Puschban Z., Ghorayeb I., Goebel G.P., Tison F., Jellinger K., Poewe W., Wenning G.K. Complex motor disturbances in a sequential double lesion rat model of striatonigral degeneration (multiple system atrophy). Neuroscience. 99:2000;43-54.
26. Schrag A., Quinn N. Dyskinesias and motor fluctuations in Parkinson's disease. A community-based study. Brain. 123:2000;2297-2305.
27. Steece-Collier K., Collier T.J., Danielson P.D., Kurlan R., Yurek D.M., Sladek J.R. Embryonic mesencephalic grafts increase levodopa-induced forelimb hyperkinesia in parkinsonian rats. Mov. Disord. 18:2003;1442-1454.
28. Tillerson J.L., Cohen A.D., Philhower J., Miller G.W., Zigmond M.J., Schallert T. Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine. J. Neurosci. 21:2001;4427-4435.
29. Tison F., Yekhlef F., Chrysostome V., Balestre E., Quinn N.P., Poewe W., Wenning G.K. Parkinsonism in multiple system atrophy: natural history, severity (UPDRS-III), and disability assessment compared with Parkinson's disease. Mov. Disord. 17:2002;701-709.
30. Wenning G.K., Ben Shlomo Y., Magalhaes M., Daniel S.E., Quinn N.P. Clinical features and natural history of multiple system atrophy. An analysis of 100 cases. Brain. 117:1994;835-845.
31. Wenning G.K., Granata R., Laboyrie P.M., Quinn N.P., Jenner P., Marsden C.D. Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration. Mov. Disord. 11:1996;522-532.
32. Wenning G.K., Tison F., Scherfler C., Puschban Z., Waldner R., Granata R., Ghorayeb I., Poewe W. Towards neurotransplantation in multiple system atrophy: clinical rationale, pathophysiological basis, and preliminary experimental evidence. Cell Transplant. 9:2000;279-288.
33. Wenning G.K., Seppi K., Tison F., Jellinger K. A novel grading scale for striatonigral degeneration (multiple system atrophy). J. Neural Transm. 109:2002;307-320.
34. Wenning G.K., Geser F., Stampfer-Kountchev M., Tison F. Multiple system atrophy: an update. Mov. Disord. 6(Suppl.):2003;S34-S42.
35. Westin J.E., Andersson M., Lundblad M., Cenci M.A. Persistent changes in striatal gene expression induced by long-term L-DOPA treatment in a rat model of Parkinson's disease. Eur. J. Neurosci. 14:2001;1171-1176.
36. Winkler C., Kirik D., Bjorklund A., Cenci M.A. L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of Parkinson's disease: relation to motor and cellular parameters of nigrostriatal function. Neurobiol. Dis. 10:2002;165-186.