Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex

Journal of Virology

Volumn 71, Issue 2, 1997, Pages 1115-1123

  Rubenwolf, Susanne ^a   Schütt, Holger ^a   Nevels, Michael ^a   Wolf, Hans ^a   Dobner, Thomas ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

ADENOVIRUS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; TRANSPORT KINETICS; VIRUS CELL TRANSFORMATION;

EID: 1842416600     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.2.1115-1123.1997     Document Type: Article

References (56)

1. Babiss, L. E., and H. S. Ginsberg. 1984. Adenovirus type 5 early region Ib gene product is required for efficient shutoff of host protein synthesis. J. Virol. 50:202-212.
2. Babiss, L. E., H. S. Ginsberg, and J. J. Darnell. 1985. Adenovirus E1B proteins are required for accumulation of lute viral mRNA and for effects on cellular mRNA translation and transport. Mol. Cell. Biol. 5:2552-2558.
3. Barker, D. D., and A. J. Berk. 1987. Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology 156:107-121.
4. Blair-Zajdel, M. E., and G. E. Blair. 1988. The intracellular distribution of the transformation-associated protein p53 in adenovirus-transformed rodent cells. Oncogene 2:579-584.
5. Boulanger, P. A., and G. E. Blair. 1991. Expression and interactions of human adenovirus oncoproteins. Biochcm. J. 275:281-299.
6. Braithwaite, A. W., and J. R. Jenkins. 1989. Ability of p53 and the adenovirus E1b 58-kilodalton protein to form a complex is determined by p53. J. Virol. 63:1792-1799.
7. Bridge, E., and G. Ketner. 1990. Interaction of adenoviral E4 and E1b products in late gene expression. Virology 174:345-353.
8. Brown, C. R., S. J. Doxsey, E. White, and W. J. Welch. 1994. Both viral (adenovirus E1B) and cellular (hsp70, p53) components interact with centrosomes. J. Cell. Physiol. 160:47-60.
9. Cutt, J. R., T. Shenk, and P. Hearing. 1987. Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells J. Virol. 61:543-552.
10. 9a.Dobner, T. Unpublished data.
11. Dobner, T., N. Horikoshi, S. Rubenwolf, and T. Shenk. 1996. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science 272:1470-1473.
12. Gaynor, R. B., D. Hillman, and A. J. Berk. 1984. Adenovirus early region 1A protein activates transcription of a novel gene introduced into mammalian cells by infection or transfection. Proc. Natl. Acad. Sci. USA 81:1193-1197.
13. Giard, R. J., S. A. Aaronson, G. J. Todaro, P. Arnstein, J. H. Kersey, H. Dosik, and W. P. Parks. 1973. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J. Natl. Cancer lnst. 51:1417-1423.
14. Graham, F. L., J. Smiley, W. C. Russel, and R. Nairn. 1977. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36:59-72.
15. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
16. Grand, R. J., and P. H. Gallimore. 1984. Adenovirus type 12 early region 1 proteins: a study of their subcellular localization and protein-protein interactions. J. Gen. Virol. 65:2149-2166.
17. Grand, R. J., M. L. Grant, and P. H. Gallimore. 1994. Enhanced expression of p53 in human cells infected with mutant adenoviruses. Virology 203:229-240.
18. Halbert, D. N., J. R. Cutt, and T. Shenk. 1985. Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. J. Virol. 56:250-257.
19. Hearing, P., and T. Shenk. 1985. Sequence-independent autoregulation of the adenovirus type E1A transcription unit. Mol. Cell. Biol. 5:3214-3221.
20. Huang, M. M., and P. Hearing. 1989. Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection. J. Virol. 63:2605-2615.
21. Kaelin, W. G., W. Krek, W. R. Sellers, J. A. DeCaprio, F. Ajchenbaum, C. S. Fuchs, T. Chittenden, Y. Li, P. J. Farnham, M. A. Blanar, D. M. Livingston, and E. K. Flemington. 1992. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:351-364.
22. Kao, C. C., P. R. Yew, and A. J. Berk. 1990. Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins. Virology 179:806-814.
23. Karasuyama, H., N. Tohyama, and T. Tada. 1989. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J. Exp. Med. 169:13-25.
24. Leppard, K. N., and T. Shenk. 1989. The adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolism. EMBO J, 8:2329-2336.
25. Liang, S., M. Hitomi, and A. M. Tartakoff. 1995. Adenoviral E1B-55kDa protein inhibits yeast mRNA export and perturbs nuclear structure. Proc. Natl. Acad. Sci. USA 92:7372-7375.
26. Logan, J., S. Pilder, and T. Shenk. 1984. Functional analysis of adenovirus type 5 early region 1B. Cancer Cells 2:527-532.
27. Malette, P., S. P. Yee, and P. E. Branton. 1983. Studies on the phosphorylation of the 58,000 dalton early region 1B protein of adenovirus type 5. J. Gen. Virol. 64:1069-1078.
28. Marton, M. J., S. B. Baim, D. A. Ornelles, and T. Shenk. 1990. The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA. J. Virol. 64:2345-2359.
29. Matlashewski, G., L. Banks, D. Pim, and L. Crawford. 1986. Analysis of human p53 proteins and mRNA levels in normal and transformed cells. Eur. J. Biochem. 154:665-672.
30. Mitsudomi, T., S. M. Steinberg, M. M. Nau, D. Carbone, D. D'Amico, H. K. Bodner, H. K. Oie, R. I. Linnoila, J. L. Mulshine, J. D. Minna, and A. F. Gazdar. 1992. p53 gene mutations in non-small-lung cell cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene 7:171-180.
31. Neill, S. D., C. Hemstrom, A. Virtanen, and J. R. Nevins. 1990. An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F. Proc. Natl. Acad. Sci. USA 87:2008-2012.
32. Niman, H. L., R. A. Houghten, L. E. Walker, R. A. Reisfeld, I. A. Wilson, J. M. Hogle, and R. A. Lerner. 1983. Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition. Proc. Natl. Acad. Sci. USA 80:4949-4953.
33. Nordqvist, K., and G. Akusjärvi. 1990. Adenovirus early region 4 stimulates mRNA accumulation via 5′ introns. Proc. Natl. Acad. Sci. USA 87:9543-9547.
34. Nordqvist, K., K. Öhman, and G. Akusjärvi. 1994. Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs. Mol. Cell. Biol. 14:437-445.
35. Obert, S., R. J. O'Connor, S. Schmid, and P. Hearing. 1994. The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complex. Mol. Cell. Biol. 14:1333-1346.
36. Öhman, K., K. Nordqvist, and G. Akusjärvi. 1993. Two adenovirus proteins with redundant activities in virus growth facilitates tripartite leader mRNA accumulation. Virology 194:50-58.
37. O'Reilly, D. R., L. K. Miller, and V. A. Luckow. 1992. Baculovirus expression vectors: a laboratory manual. W. H. Freeman & Co., New York, N.Y.
38. Ornelles, D. A., and T. Shenk. 1991. Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein. J. Virol. 65:424-429.
39. Pilder, S., M. Moore, J. Logan, and T. Shenk. 1986. The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol. Cell. Biol. 6:470-476.
40. Rowe, D. T., P. E. Branton, and F. L. Graham. 1984. The kinetics of synthesis of early viral proteins in KB cells infected with wild-type and transformation-defective host-range mutants of human adenovirus type 5. J. Gen. Virol. 65:585-597.
41. Rowe, D. T., F. L. Graham, and P. E. Branton. 1983. Intracellular localization of adenovirus type 5 tumor antigens in productively infected cells. Virology 129:456-468.
42. 40a.Rubenwolf, S., and T. Dobner. Unpublished data.
43. Sandler, A. B., and G. Ketner. 1989. Adenovirus early region 4 is essential for normal stability of late nuclear RNAs. J. Virol. 63:624-630.
44. Sarnow, P., P. Hearing, C. W. Anderson, D. N. Halbert, T. Shenk, and A. J. Levine. 1984. Adenovirus early-region 1B 58,000-dalton tumor antigen is physically associated with an early-region 4 25,000-dalton protein in productively infected cells. J. Virol. 49:692-700.
45. Sarnow, P., C. A. Sullivan, and A. J. Levine. 1982. A monoclonal antibody detecting the adenovirus type 5-E1b-58Kd tumor antigen: characterization of the E1b-58Kd tumor antigen in adenovirus-intected and -transformed cells. Virology 120:510-517.
46. Smiley, J. K., M. A. Young, and S. J. Flint. 1990. Intranuclear location of the adenovirus type 5 E1B 55-kilodalton protein. J. Virol. 64:4558-1564.
47. Stillman, B. 1986. Functions of the adenovirus E1B tumour antigens. Cancer Surv. 5:389-404.
48. Teodora, J. G., T. Halliday, S. G. Whalen, D. Takayesu, F. L. Graham, and P. E. Branton. 1994. Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity. J. Virol. 68:776-786.
49. Triezenberg, S. J., R. C. Kingsbury, and S. L. McKnight. 1988. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev. 2:718-729.
50. Weinberg, D. H., and G. Ketner. 1986. Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression. J. Virol. 57:833-838.
51. Weinberg, D. H., and G. Ketner. 1983. A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2. Proc. Natl. Acad. Sci. USA 80:5383-5386.
52. Williams, J., B. D. Karger, Y. S. Ho, C. L. Castiglia, T. Mann, and S. J. Flint. 1986. The adenovirus E1B 495R protein plays a role in regulating the transport and stability of the viral late messages. Cancer Cells 4:275-284.
53. Yew, P. R., and A. J. Berk. 1992. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357:82-85.
54. Yew, P. R., C. C. Kao, and A. J. Berk. 1990. Dissection of functional domains in the adenovirus 2 early 1B 55K polypeptide by suppressor-linker insertional mutagenesis. Virology 179:795-805.
55. Yew, P. R., X. Liu, and A. J. Berk. 1994. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev. 8:190-202.
56. Zantema, A., J. A. Fransen, O. A. Davis, F. C. Ramaekers, G. P. Vooijs, B. DeLeys, and A. J. van der Eb. 1985. Localization of the E1B proteins of adenovirus 5 in transformed cells, as revealed by interaction with monoclonal antibodies. Virology 142:44-58.