Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 10, 2002, Pages 1429-1433

  Wei, Ling ^a   Wu, Yong Qian ^a   Wilkinson, Douglas E ^a   Chen, Yi ^a   Soni, Raj ^a   Scott, Chad ^a   Ross, Douglas T ^a   Guo, Hong ^a   Howorth, Pamela ^a   Valentine, Heather ^a   Liang, Shi ^a   Spicer, Dawn ^a   Fuller, Mike ^a   Steiner, Joseph ^a   Hamilton, Gregory S ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; CYCLOPHILIN; ENZYME FKBP12; ENZYME INHIBITOR; FKBP12 INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; METHODOLOGY; MOUSE; NONHUMAN; PARKINSON DISEASE; SOLID;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; CARBAMATES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; ENZYME INHIBITORS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARKINSONIAN DISORDERS; PIPECOLIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; TACROLIMUS BINDING PROTEINS;

EID: 18344393965     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00146-4     Document Type: Article

References (9)